Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the recognition molecule C1q to the C1 complex triggers its autoactivation via C1r, the C-reactive protein, CRP, activates the C1 complex by binding to C1q | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic interaction anaylsis of the C1 complex and regulatory proteins, e.g. the C-reactive protein, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | as C1 complex, i.e. C1s-C1r-C1r-C1s tetramer | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C1s + H2O | Homo sapiens | the enzyme is part of the Ca2+-dependent tetramer C1s-C1r-C1r-C1s, termed as C1 complex, which is associated with the recognition molecule C1q, autoactivation of C1r, which then activates proenzyme C1s through cleavage at an Arg-Ile bond in the serine domain, C1r is active in the classical pathway of the complement system, interaction anaylsis of the C1 complex and regulatory proteins, overview | activated complement component C1s + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Renatured (Comment) | Organism |
---|---|
reconstitution of the C1 complex using purified C1q, C1r and C1s in the presence of C1-INH, interaction with C-reactive protein CRP, overview | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C1s + H2O | the enzyme is part of the Ca2+-dependent tetramer C1s-C1r-C1r-C1s, termed as C1 complex, which is associated with the recognition molecule C1q, autoactivation of C1r, which then activates proenzyme C1s through cleavage at an Arg-Ile bond in the serine domain, C1r is active in the classical pathway of the complement system, interaction anaylsis of the C1 complex and regulatory proteins, overview | Homo sapiens | activated complement component C1s + ? | - |
? | |
complement component C1s + H2O | C1r cleaves proenzyme C1s at an Arg-Ile bond in the serine domain | Homo sapiens | activated complement component C1s + ? | - |
? |