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Literature summary for 3.4.21.41 extracted from

  • Biro, A.; Rovo, Z.; Papp, D.; Cervenak, L.; Varga, L.; Fuest, G.; Thielens, N.M.; Arlaud, G.J.; Prohaszka, Z.
    Studies on the interactions between C-reactive protein and complement proteins (2007), Immunology, 121, 40-50.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information the recognition molecule C1q to the C1 complex triggers its autoactivation via C1r, the C-reactive protein, CRP, activates the C1 complex by binding to C1q Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetic interaction anaylsis of the C1 complex and regulatory proteins, e.g. the C-reactive protein, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular as C1 complex, i.e. C1s-C1r-C1r-C1s tetramer Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C1s + H2O Homo sapiens the enzyme is part of the Ca2+-dependent tetramer C1s-C1r-C1r-C1s, termed as C1 complex, which is associated with the recognition molecule C1q, autoactivation of C1r, which then activates proenzyme C1s through cleavage at an Arg-Ile bond in the serine domain, C1r is active in the classical pathway of the complement system, interaction anaylsis of the C1 complex and regulatory proteins, overview activated complement component C1s + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Renatured (Commentary)

Renatured (Comment) Organism
reconstitution of the C1 complex using purified C1q, C1r and C1s in the presence of C1-INH, interaction with C-reactive protein CRP, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C1s + H2O the enzyme is part of the Ca2+-dependent tetramer C1s-C1r-C1r-C1s, termed as C1 complex, which is associated with the recognition molecule C1q, autoactivation of C1r, which then activates proenzyme C1s through cleavage at an Arg-Ile bond in the serine domain, C1r is active in the classical pathway of the complement system, interaction anaylsis of the C1 complex and regulatory proteins, overview Homo sapiens activated complement component C1s + ?
-
?
complement component C1s + H2O C1r cleaves proenzyme C1s at an Arg-Ile bond in the serine domain Homo sapiens activated complement component C1s + ?
-
?