Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.6.3.1: NAD(P)H oxidase (H2O2-forming)

This is an abbreviated version!
For detailed information about NAD(P)H oxidase (H2O2-forming), go to the full flat file.

Word Map on EC 1.6.3.1

Reaction

NAD(P)H
+
H+
 +
O2
=
NAD(P)+
 +
H2O2

Synonyms

100787949, 100812342, 100820185, Atrbohc, AtrbohD NADPH oxidase, AtrbohF NADPH oxidase, BLI-3, cytochrome b-245 heavy chain, dual oxidase, Duox, Duox-DuoxA NADPH oxidase, Duox1, Duox2, Glyma.03G236300, Glyma.19G233900, Glyma.20G236200, GLYMA_10G152200, gp91phox, gp91phox/Nox2, KOD1, large NOX, LNOX, NAD(P)H oxidase, NAD(P)H oxidase 4, NADH oxidase, NADPH oxidase, NADPH oxidase 1, NADPH oxidase 2, NADPH oxidase 4, NADPH oxidase 5, NADPH oxidase type 4, NADPH-oxidase, NADPHox, NAPDH oxidase, NM_001184780, NOX, NOX1, Nox2, NOX3, Nox4, NOX4-art, NOX5, p138 thyroid-oxidase, p138tox, p47phox, p67phox, phagocyte NADPH oxidase, phox, RBOH, RBOHB, RbohF, RDH2, RdxA, renal oxidase, renox, Respiratory Burst Oxidase Homolog, respiratory burst oxidase homologue, rth5, SsNOX38, superoxide-generating NADPH oxidase, ThOX, ThOX2, thyroid NADPH oxidase, thyroid oxidase, thyroid oxidase 2, TK0304, TK0828, TK1186, TK1299, TK1481

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.3 With oxygen as acceptor
                1.6.3.1 NAD(P)H oxidase (H2O2-forming)

Localization

Localization on EC 1.6.3.1 - NAD(P)H oxidase (H2O2-forming)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
Burkholderia cenocepacia resides in macrophage vacuoles displaying an altered recruitment of the NADPH oxidase complex at the phagosomal membrane
Manually annotated by BRENDA team
-
after Fcgamma receptor-induced phagocytosis, yellow fluorescent protein-tagged subunits p67phox and p40phox translocate to granulocyte phagosomes before phagosome internalization and accumulation of a probe for phosphoinositol 3-phosphate. p67phox and p47phox accumulation on nascent and internalized phagosomes does not require p40phox or PI3 kinase activity. Translocation of p40phox to nascent phagosomes requires binding to p67phox but not phosphoinositol 3-phosphate
-
Manually annotated by BRENDA team
-
synaptic and extrasynaptic areas of the plasmalemma, localization of subunit p47phox, in dorsomedial nucleus tractus solitarius neurons of saline-treated animals. Chronic administration of phenylephrine, which produces increases in systolic blood pressure, is associated with a repartitioning of p47phox immunolabeling away from intracellular organelles in distal dendritic areas, and toward the plasma membrane of intermediate dendritic areas of dorsomedial nucleus tractus solitarius neurons
-
Manually annotated by BRENDA team
-
local production of superoxide anion, which is increased by M1-receptor agonist, oxotremorine and Ca2+ ionophore, A23187, increased. Inhibitors diphenylene iodonium and apocynin, or superoxide dismutase and catalase, and subunit Nox4 siRNA all substantially block this local production of superoxide anion. Sarcoplasmic superoxide anion producing system is controlled by cADPR-RyR/Ca2+ signaling pathway
Manually annotated by BRENDA team
-
in resting cells, enzyme complex components p22phox and gp91phox are located in the plasma membrane and membranes of specific granules
Manually annotated by BRENDA team
-
critical role for granules as a site for assembly and activation of the oxidase enzyme system
Manually annotated by BRENDA team
additional information