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Literature summary for 1.6.3.1 extracted from

  • Zhang, R.; Harding, P.; Garvin, J.L.; Juncos, R.; Peterson, E.; Juncos, L.A.; Liu, R.
    Isoforms and functions of NAD(P)H oxidase at the macula densa (2009), Hypertension, 53, 556-563.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Rattus norvegicus 16020
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q924V1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macula densa NOX2 and NOX4 are the main isoforms present in macula densa cells Rattus norvegicus
-
MMDD-1 cell
-
Rattus norvegicus
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renal epithelium
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + O2
-
Rattus norvegicus NADP+ + H2O2
-
?

Synonyms

Synonyms Comment Organism
Nox2
-
Rattus norvegicus
Nox4
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus NOX2 and NOX4 activity is induced by 70 and 140 mM NaCl up

General Information

General Information Comment Organism
physiological function while macula densa cells express the NOX2 and NOX4 isoforms, NOX 2 is primarily responsible for NaCl-induced O2- generation Rattus norvegicus