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Literature summary for 1.6.3.1 extracted from

  • Donko, A.; Morand, S.; Korzeniowska, A.; Boudreau, H.E.; Zana, M.; Hunyady, L.; Geiszt, M.; Leto, T.L.
    Hypothyroidism-associated missense mutation impairs NADPH oxidase activity and intracellular trafficking of Duox2 (2014), Free Radic. Biol. Med., 73, 190-200 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.6.3.1

Protein Variants

Protein Variants Comment Organism
V674G the mutation is associated with severe congenital hypothyroidism. The mutant enzyme fails to release extracellular H2O2 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Mus musculus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADPH + H+ + O2 Mus musculus
-
 NADP+ + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
salivary gland
-
 Mus musculus
-
thyroid gland
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + O2
-
 Mus musculus NADP+ + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
Duox2
-
 Mus musculus
NADPH oxidase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Mus musculus