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Literature summary for 1.6.3.1 extracted from

  • Moreno, J.C.; Bikker, H.; Kempers, M.J.; van Trotsenburg, A.S.; Baas, F.; de Vijlder, J.J.; Vulsma, T.; Ris-Stalpers, C.
    Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism (2002), N. Engl. J. Med., 347, 95-102.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
apical plasma membrane
-
Homo sapiens 16324
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ regulates enzyme activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD(P)H + H+ + O2 Homo sapiens enzyme deficiency causes serious hypothyroidism NAD(P)+ + H2O2
-
?
NAD(P)H + H+ + O2 Homo sapiens production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NRD8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
thyroid gland follicular cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD(P)H + H+ + O2
-
Homo sapiens NAD(P)+ + H2O2
-
?
NAD(P)H + H+ + O2 enzyme deficiency causes serious hypothyroidism Homo sapiens NAD(P)+ + H2O2
-
?
NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Homo sapiens NAD(P)+ + H2O2
-
?

Cofactor

Cofactor Comment Organism Structure
FAD binding site Homo sapiens