1.6.3.1: NAD(P)H oxidase (H2O2-forming) This is an abbreviated version! For detailed information about NAD(P)H oxidase (H2O2-forming), go to the full flat file .
Reaction
NAD(P)H +
H+ +
O2 =
NAD(P)+ +
H2O2
Synonyms 100787949, 100812342, 100820185, Atrbohc, AtrbohD NADPH oxidase, AtrbohF NADPH oxidase, BLI-3, cytochrome b-245 heavy chain, dual oxidase, Duox, Duox-DuoxA NADPH oxidase, Duox1, Duox2, Glyma.03G236300, Glyma.19G233900, Glyma.20G236200, GLYMA_10G152200, gp91phox, gp91phox/Nox2, KOD1, large NOX, LNOX, NAD(P)H oxidase, NAD(P)H oxidase 4, NADH oxidase, NADPH oxidase, NADPH oxidase 1, NADPH oxidase 2, NADPH oxidase 4, NADPH oxidase 5, NADPH oxidase type 4, NADPH-oxidase, NADPHox, NAPDH oxidase, NM_001184780, NOX, NOX1, Nox2, NOX3, Nox4, NOX4-art, NOX5, p138 thyroid-oxidase, p138tox, p47phox, p67phox, phagocyte NADPH oxidase, phox, RBOH, RBOHB, RbohF, RDH2, RdxA, renal oxidase, renox, Respiratory Burst Oxidase Homolog, respiratory burst oxidase homologue, rth5, SsNOX38, superoxide-generating NADPH oxidase, ThOX, ThOX2, thyroid NADPH oxidase, thyroid oxidase, thyroid oxidase 2, TK0304, TK0828, TK1186, TK1299, TK1481
ECTree
Organism
Organism on EC 1.6.3.1 - NAD(P)H oxidase (H2O2-forming)
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Duox, dual specificity enzyme NADPH oxidase/peroxidase
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isoform NADPH oxidase 5
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cultivar Golden Delicious
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rice pathogen, which undergoes an oxidative blast of its own during plant infection
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gene nox1
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gene nox1
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isoform RbohD
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isoform Rhd2/Atrbohc
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multienzyme complex
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high sequence similarities to mammalian proteins
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subunit gp91phox
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subunit p22phox
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subunit p47phox
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subunit p67phox
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isoform RBOHB, member of group six of orthologues based on phylogenetic analysis with their Arabidopsis counterparts
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isoform RBOHL, member of group six of orthologues based on phylogenetic analysis with their Arabidopsis counterparts
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isoform RBOHP, member of group six of orthologues based on phylogenetic analysis with their Arabidopsis counterparts
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isoform RBOHQ, member of group six of orthologues based on phylogenetic analysis with their Arabidopsis counterparts
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636501 , 658889 , 659332 , 659626 , 659956 , 671246 , 671829 , 673788 , 684695 , 684771 , 684779 , 684781 , 684859 , 684866 , 684872 , 684904 , 684970 , 685016 , 685277 , 685410 , 685793 , 685998 , 686126 , 686418 , 686520 , 686556 , 686848 , 686879 , 686880 , 687050 , 687587 , 687620 , 687649 , 687674 , 687742 , 688206 , 688216 , 688583 , 688599 , 688605 , 688753 , 689213 , 696030 , 696573 -
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699176 , 699287 , 700052 , 710782 , 710897 , 711166 , 711688 , 711763 , 712075 , 712673 , 712711 , 712713 , 713338 , 713360 , 724704 , 724778 , 726081 , 741619 , 742310 , 742556 , 742557 , 743686 -
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children with acute asthma
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dual NADPH oxidases/peroxidases, Duox1 and Duox2. Regulation of expression by immunomodulatory Th1 and Th2 cytokines
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female
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high-risk cardiac patients with aspirin resistance
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i.e. membrane subunit gp91phox
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isoform dual oxidase 2
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isoform Duox2
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isoform Nox1
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isoform Nox2, reconmbinant enzyme
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isoform Nox3
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isoform Nox4, expression in patients with neuroepithelial tumors
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isoform Nox5-S
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isoform THOX2, patients with congenital thyroidism
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isoforms Duox1, Duox2, stable transfection in HEK293 and Chinese hamster ovary cells. Enzymes demonstrate a functional NADPH/Ca2+-dependent H2O2-generating activity. Human Duox2 is more active than human Duox1, but only half as active as its porcine counterpart
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multicomponent NADPH-oxidase consisting of a heterodimeric flavocytochrome b558, localized in the membrane and at least two cytosolic components p47-phox and p67-phox, enzyme plays a role in chronic granulomatous diseases, enzyme system is activated upon exposure to the appropriate stimuli leading to assembly in the plasma membrane of membrane-bound and cytosolic components
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multienzyme complex
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patients with atherosclerosis
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patients with bronchial asthma
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patients with idiopathic pulmonary arterial hypertension
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patients with sickle cell disease
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subunit cytochrome b-245 heavy chain
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674633 , 684345 , 684358 , 684361 , 684500 , 684839 , 685335 , 685345 , 685384 , 685878 , 685971 , 685975 , 685982 , 686030 , 686113 , 686115 , 686878 , 687451 , 687674 , 687798 , 687930 , 688150 , 688219 , 688531 , 688583 , 688597 , 689225 , 690084 , 690131 , 690132 , 690180 , 697153 , 697415 , 698160 , 701019 , 710782 , 710816 , 711090 , 711688 , 711698 , 711763 , 711828 , 712573 , 713338 , 725065 , 742557 , 742560 , 743287 -
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apolipoprotein E-deficient mice, which display vascular oxidative stress
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fed with normal or cholesterol-enriched diet
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female wild-type and NAD(P)H oxidase deficient gp91phox knock-out mice
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hypertensive mice with spontaneous intracranial hemorrhage
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isoform dual oxidase 2
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isoform Nox1
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isoform NoxII
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phagocyte NADPH oxidase-deficient mice
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streptozotocin-induced diabetic apoE-deficient mouse
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wild-type, Cu,Zn-superoxide dismutase transgenic, and NAD(P)H oxidase-knockout mice placed on a normal or high cholesterol diet
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671217 , 672959 , 673106 , 675531 , 684269 , 684343 , 684364 , 684977 , 685873 , 685888 , 686306 , 686562 , 686602 , 686616 , 686848 , 686859 , 686862 , 686883 , 687050 , 687051 , 687053 , 688446 , 688530 , 688531 , 688550 , 688627 , 688711 , 689235 , 699700 , 700427 , 711166 , 711645 , 711688 , 711731 , 711856 , 712062 -
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cell line PC C-13
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DAHl salt-sensitive and -resistant rats
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diabetic hypertensive rats
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enzymes xanthine oxidase and xanthine dehydrogenase catalyze NADH oxidation, generating superoxide radicals
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newborn rats
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obese Zucker rats
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spontaneously hypertensive rats
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transgenic rats harboring the mouse renin transgene and exhibiting elevated tissue angiotensin II levels
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isoforms Strboh A-D, and Strboh F
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isoform Duox2
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isoforms Duox1, Duox2, stable transfection in HEK293 and Chinese hamster ovary cells. Enzymes demonstrate a functional NADPH/Ca2+-dependent H2O2-generating activity. Human Duox2 is only half as active as its porcine counterpart
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gene tk0304
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