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Literature summary for 1.6.3.1 extracted from

  • Loughlin, D.T.; Artlett, C.M.
    Precursor of advanced glycation end products mediates ER-stress-induced caspase-3 activation of human dermal fibroblasts through NAD(P)H oxidase 4 (2010), PLoS ONE, 5, e11093.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.6.3.1

Inhibitors

Inhibitors Comment Organism Structure
apocynin broad class Nox inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dermal fibroblast dermal fibroblasts overexpress specifically Nox4 Homo sapiens
-

Synonyms

Synonyms Comment Organism
NAD(P)H oxidase 4
-
 Homo sapiens
Nox4
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens Nox4 mRNA expression increases to 88% in fibroblasts cultured on 3-deoxyglucosone-collagen for 24 h compared to fibroblasts cultured on native collagen up

General Information

General Information Comment Organism
physiological function oxidative stress is dependent on the upregulation of NAD(P)H oxidase 4, a reactive oxygen species Nox homologue, triggering endoplasmic reticulum stress. The endoplasmic reticulum stress pathway through activation of Nox4 by integrins alpha1beta1 plays a key role in 3-deoxyglucosone-collagen-induced caspase-3 activation, which may play an important role in the pathogenesis of diabetic wounds Homo sapiens