1.2.1.104: pyruvate dehydrogenase system

This is an abbreviated version!
For detailed information about pyruvate dehydrogenase system, go to the full flat file.

Reaction

Synonyms

aceE, AceF, At1g54220, At3g13930, At3g52200, CTHT_0006350, CTHT_0069820, dihydrolipoamide acetyltransferase, dihydrolipoyllysine-residue acetyltransferase component, DLAT, DLD, DLST, E1 component of pyruvate dehydrogenase complex, E1 component subunit alpha, E1 component subunit beta, IAR4, LpdA, Lta3, MAB1, More, Mrp-3, Pda1, Pda1p, PDC, PDCp, PDH, PDH complex, PDH-E1 catalytic subunit, PDHa, PdhA1, PDHalpha, PdhB1, PDHC, PdhE, PDHE1alpha1, PdhH, PdhX, PH2, plastidial pyruvate dehydrogenase complex, pyruvate decarboxylase, pyruvate dehydrogenase, pyruvate dehydrogenase alpha subunit, pyruvate dehydrogenase complex, pyruvate dehydrogenase E1

ECTree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.104 pyruvate dehydrogenase system

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Results	in table
19	Activating Compound
12	AA Sequence
12	Application
13	Cloned(Commentary)
51	Cofactor
10	Crystallization (Commentary)
215	Disease/ Diagnostics
2	Expression
28	General Information
8	General Stability
35	IC50 Value
124	Inhibitors
4	kcat/KM [mM/s]
25	Ki Value [mM]
88	KM Value [mM]
50	Localization
27	Metals/Ions
53	Molecular Weight [Da]
30	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
466	Organism
1	Oxidation Stability
8	Pathway
24	pH Optimum
2	pH Range
4	pH Stability
25	Posttranslational Modification
52	Protein Variants
40	Purification (Commentary)
3	Reaction
188	Reference
7	Renatured (Commentary)
70	Source Tissue
25	Specific Activity [micromol/min/mg]
9	Storage Stability
93	Substrates and Products (Substrate)
48	Subunits
88	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
1	Temperature Range [°C]
9	Temperature Stability [°C]
12	Turnover Number [1/s]

KI Value

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KI Value on EC 1.2.1.104 - pyruvate dehydrogenase system

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0.0006

2-p-Toluidinonaphthalene-6-sulfonate

Saccharomyces pastorianus

assay with whole enzyme complex, competitive inhibition

348977

0.0098 - 0.079

acetyl-CoA

3 entries

0.00146 - 0.0033

acetylmethylphosphinate

2 entries

0.000014 - 0.00076

Acetylphosphinate

2 entries

2.25

alpha-Ketobutyric acid

Escherichia coli

assay with whole enzyme complex

348956

beta-Hydroxypyruvate

Escherichia coli

assay with whole enzyme complex

348956

0.028

Bromopyruvate

Escherichia coli

assay with whole enzyme complex

348956

0.0014 - 0.02

Fluoropyruvate

2 entries

0.051 - 3.27

glyoxylate

3 entries

0.5

glyoxylic acid

Escherichia coli

assay with whole enzyme complex

348956

0.11

Hydroxypyruvate

Brassica oleracea

348969

0.015 - 0.12

NADH

5 entries

0.02

Pyruvamide

Bos taurus

pH 7.6, 30°C, overall reaction of complex

672469

0.51

Sodium diphosphate

Escherichia coli

348943