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1.2.1.104: pyruvate dehydrogenase system

This is an abbreviated version!
For detailed information about pyruvate dehydrogenase system, go to the full flat file.

Reaction

pyruvate
+
CoA
+
NAD+
=
acetyl-CoA
+
CO2
+
NADH

Synonyms

aceE, AceF, At1g54220, At3g13930, At3g52200, CTHT_0006350, CTHT_0069820, dihydrolipoamide acetyltransferase, dihydrolipoyllysine-residue acetyltransferase component, DLAT, DLD, DLST, E1 component of pyruvate dehydrogenase complex, E1 component subunit alpha, E1 component subunit beta, IAR4, LpdA, Lta3, MAB1, More, Mrp-3, Pda1, Pda1p, PDC, PDCp, PDH, PDH complex, PDH-E1 catalytic subunit, PDHa, PdhA1, PDHalpha, PdhB1, PDHC, PdhE, PDHE1alpha1, PdhH, PdhX, PH2, plastidial pyruvate dehydrogenase complex, pyruvate decarboxylase, pyruvate dehydrogenase, pyruvate dehydrogenase alpha subunit, pyruvate dehydrogenase complex, pyruvate dehydrogenase E1

ECTree

     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.1 With NAD+ or NADP+ as acceptor
                1.2.1.104 pyruvate dehydrogenase system

IC50 Value

IC50 Value on EC 1.2.1.104 - pyruvate dehydrogenase system

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0061 - 0.0069
1-(4-bromophenyl)ethanone O-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)oxime
0.0067
1-(4-nitrophenyl)ethanone O-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)oxime
Escherichia coli
pH 6.4, 37°C
0.0059
2-([1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-iodo-4,5-dihydro-1H-1,2,3-triazol-4-yl]methyl)-1H-isoindole-1,3(2H)-dione
Escherichia coli
pH 6.4, 37°C
0.00212
3-([1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4,5-dihydro-1H-1,2,3-triazol-4-yl]methyl)-5-chloroquinazolin-4(3H)-one
Escherichia coli
pH 6.4, 37°C
0.0043
3-([1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4,5-dihydro-1H-1,2,3-triazol-4-yl]methyl)-6-bromoquinazolin-4(3H)-one
Escherichia coli
pH 6.4, 37°C
8.21
3-([1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-iodo-4,5-dihydro-1H-1,2,3-triazol-4-yl]methyl)-6-bromoquinazolin-4(3H)-one
Escherichia coli
pH 6.4, 37°C
0.00362
3-([1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-iodo-4,5-dihydro-1H-1,2,3-triazol-4-yl]methyl)-6-chloro-1,2,3-benzotriazin-4(3H)-one
Escherichia coli
pH 6.4, 37°C
0.0000026
3-deazathiamine diphosphate
Sus scrofa
-
pH 7.8, temperature not specified in the publication
0.0101
4-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-iodo-1H-1,2,3-triazol-4-yl)methoxy)benzonitrile
Escherichia coli
-
isolated E1 component, pH 6.5, 37°C
0.0042
5-((4-((4-bromophenoxy)methyl)-5-iodo-1H-1,2,3-triazol-1-yl)methyl)-2-methylpyrimidin-4-amine
Escherichia coli
-
isolated E1 component, pH 6.5, 37°C
0.0051
5-((4-((4-chloro-3-methylphenoxy)methyl)-5-iodo-1H-1,2,3-triazol-1-yl)methyl)-2-methylpyrimidin-4-amine
Escherichia coli
-
isolated E1 component, pH 6.5, 37°C
0.0118
5-((4-((4-chlorophenoxy)methyl)-5-iodo-1H-1,2,3-triazol-1-yl)methyl)-2-methylpyrimidin-4-amine
Escherichia coli
-
isolated E1 component, pH 6.5, 37°C
0.0094
N-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl) methyl)-2,4,6-trimethylbenzenesulfonamide
Synechocystis sp. PCC 6803
pH 7.2, 37°C
-
0.0046
N-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl) methyl)-2-nitrobenzenesulfonamide
Synechocystis sp. PCC 6803
pH 7.2, 37°C
-
0.0088
N-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-1H-1,2,3-triazol-4-yl) methyl)-4-bromobenzenesulfonamide
Synechocystis sp. PCC 6803
pH 7.2, 37°C
-
0.0071
N-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-iodo-1H-1,2,3-triazol-4-yl) methyl)-4-chlorobenzenesulfonamide
Synechocystis sp. PCC 6803
pH 7.2, 37°C
-
0.0068
N-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-iodo-1H-1,2,3-triazol-4-yl)methyl)-2,4,6-trimethylbenzenesulfonamide
Synechocystis sp. PCC 6803
pH 7.2, 37°C
-
0.0078
N-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-iodo-1H-1,2,3-triazol-4-yl)methyl)-4-bromobenzenesulfonamide
Synechocystis sp. PCC 6803
pH 7.2, 37°C
-
0.0086
N-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-iodo-1H-1,2,3-triazol-4-yl)methyl)-4-fluorobenzenesulfonamide
Synechocystis sp. PCC 6803
pH 7.2, 37°C
-
0.0037
N-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-iodo-1H-1,2,3-triazol-4-yl)methyl)-4-methoxybenzenesulfonamide
Synechocystis sp. PCC 6803
pH 7.2, 37°C
-
0.0096
N-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-iodo-1H-1,2,3-triazol-4-yl)methyl)-4-methylbenzenesulfonamide
Synechocystis sp. PCC 6803
pH 7.2, 37°C
-
0.0035
N-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-iodo-1H-1,2,3-triazol-4-yl)methyl)-4-nitrobenzenesulfonamide
Synechocystis sp. PCC 6803
pH 7.2, 37°C
-
0.00237
N-(3-[(2E)-2-[(4-amino-2-methylpyrimidin-5-yl)methylidene]hydrazinecarbonyl]phenyl)-2-fluorobenzamide
Escherichia coli
pH 6.4, 37°C
0.00066
N-(3-[(2E)-2-[(4-amino-2-methylpyrimidin-5-yl)methylidene]hydrazinecarbonyl]phenyl)-4-bromobenzamide
Escherichia coli
pH 6.4, 37°C
0.00191
N-(3-[(2E)-2-[(4-amino-2-methylpyrimidin-5-yl)methylidene]hydrazinecarbonyl]phenyl)-4-fluorobenzamide
Escherichia coli
pH 6.4, 37°C
0.00285
N-(3-[(2E)-2-[(4-amino-2-methylpyrimidin-5-yl)methylidene]hydrazinecarbonyl]phenyl)-4-methylbenzamide
Escherichia coli
pH 6.4, 37°C
0.00469
N-(3-[(2E)-2-[(4-amino-2-methylpyrimidin-5-yl)methylidene]hydrazinecarbonyl]phenyl)butanamide
Escherichia coli
pH 6.4, 37°C
0.00062
N-(4-[(2E)-2-[(4-amino-2-methylpyrimidin-5-yl)methylidene]hydrazinecarbonyl]phenyl)-4-bromobenzamide
Escherichia coli
pH 6.4, 37°C
0.00054
N-(4-[(2E)-2-[(4-amino-2-methylpyrimidin-5-yl)methylidene]hydrazinecarbonyl]phenyl)-N'-phenylurea
Escherichia coli
pH 6.4, 37°C
0.000025
Oxythiamine diphosphate
Sus scrofa
-
pH 7.8, temperature not specified in the publication
0.00179
[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-iodo-4,5-dihydro-1H-1,2,3-triazol-4-yl]methyl 3-chlorobenzoate
Synechocystis sp. PCC 6803
isolated E1 component, pH 7.2, 37°C
0.00148
[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-iodo-4,5-dihydro-1H-1,2,3-triazol-4-yl]methyl 4-chlorobenzoate
Synechocystis sp. PCC 6803
isolated E1 component, pH 7.2, 37°C
0.00161
[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-iodo-4,5-dihydro-1H-1,2,3-triazol-4-yl]methyl 4-fluorobenzoate
Synechocystis sp. PCC 6803
isolated E1 component, pH 7.2, 37°C
0.00169
[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-iodo-4,5-dihydro-1H-1,2,3-triazol-4-yl]methyl 4-nitrobenzoate
Synechocystis sp. PCC 6803
isolated E1 component, pH 7.2, 37°C