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Literature summary for 1.2.1.104 extracted from

  • Thissen, J.; Desai, S.; McCartney, P.; Komuniecki, R.
    Improved purification of the pyruvate dehydrogenase complex from Ascaris suum body wall muscle and characterization of PDHa kinase activity (1986), Mol. Biochem. Parasitol., 21, 129-138 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
NADH
-
Ascaris suum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0005
-
CoA pH 7.4, 30°C Ascaris suum
0.002
-
pyruvate value is 0.002 to 0.004, pH 7.4, 30°C Ascaris suum
0.01
-
NAD+ pH 7.4, 30°C Ascaris suum

Organism

Organism UniProt Comment Textmining
Ascaris suum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
purification scheme for the pyruvate dehydrogenase complex directly from body wall muscle which yields a fully activated pyruvate dehydrogenase complex with substantial PDHa kinase activity Ascaris suum

Source Tissue

Source Tissue Comment Organism Textmining
muscle body wall muscle Ascaris suum
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.8
-
pH 7.4, 30°C Ascaris suum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + CoA + NAD+
-
Ascaris suum acetyl-CoA + CO2 + NADH
-
?

Subunits

Subunits Comment Organism
multimer x * 68000, lipoate acetyltransferase, x * 54800, lipoamide dehydrogenase, x *41900, alpha-pyruvate dehydrogenase, x * 45000, beta-pyruvate dehydrogenase subunit, plus x * 45000, component X, SDS-PAGE Ascaris suum

Cofactor

Cofactor Comment Organism Structure
CoA
-
Ascaris suum
NAD+
-
Ascaris suum
NADH
-
Ascaris suum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.025
-
NADH pH 7.4, 30°C Ascaris suum