1.2.1.104: pyruvate dehydrogenase system
This is an abbreviated version!
For detailed information about pyruvate dehydrogenase system, go to the full flat file.
Reaction
Synonyms
aceE, AceF, At1g54220, At3g13930, At3g52200, CTHT_0006350, CTHT_0069820, dihydrolipoamide acetyltransferase, dihydrolipoyllysine-residue acetyltransferase component, DLAT, DLD, DLST, E1 component of pyruvate dehydrogenase complex, E1 component subunit alpha, E1 component subunit beta, IAR4, LpdA, Lta3, MAB1, More, Mrp-3, Pda1, Pda1p, PDC, PDCp, PDH, PDH complex, PDH-E1 catalytic subunit, PDHa, PdhA1, PDHalpha, PdhB1, PDHC, PdhE, PDHE1alpha1, PdhH, PdhX, PH2, plastidial pyruvate dehydrogenase complex, pyruvate decarboxylase, pyruvate dehydrogenase, pyruvate dehydrogenase alpha subunit, pyruvate dehydrogenase complex, pyruvate dehydrogenase E1
ECTree
1.2.1.104 pyruvate dehydrogenase systemAdvanced search results
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results (KM Value
KM Value on EC 1.2.1.104 - pyruvate dehydrogenase system
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.0082
hydroxyethyl thiamine diphosphate
-
pH not specified in the publication, temperature not specified in the publication
0.004
CoA
-
2-oxoglutarate dehydrogenase complex, pH 7.6, 30°C, in presence of thiamine diphosphate
0.004
CoA
-
pH not specified in the publication, temperature not specified in the publication
0.0046
CoA
-
pH not specified in the publication, temperature not specified in the publication
0.012
CoA
-
2-oxoglutarate dehydrogenase complex, pH 7.6, 30°C, in absence of thiamine diphosphate
0.0132
CoA
-
absence of malate, pH 7.6, temperature not specified in the publication
0.61
CoA
-
presence of 1 mM malate, pH 7.6, temperature not specified in the publication
0.033
NAD+
-
2-oxoglutarate dehydrogenase complex, pH 7.6, 30°C, in presence of thiamine diphosphate
0.07
NAD+
-
2-oxoglutarate dehydrogenase complex, pH 7.6, 30°C, in absence of thiamine diphosphate
0.076
NAD+
-
absence of malate, pH 7.6, temperature not specified in the publication
0.1
NAD+
-
pH not specified in the publication, temperature not specified in the publication
0.136
NAD+
-
presence of 1 mM malate, pH 7.6, temperature not specified in the publication
0.238
NAD+
-
pH not specified in the publication, temperature not specified in the publication
0.0002
pyruvate
-
2-oxoglutarate dehydrogenase complex, pH 7.6, 30°C, in presence of thiamine diphosphate, in presence of 2 mM Mn2+
0.0006
pyruvate
-
2-oxoglutarate dehydrogenase complex, pH 7.6, 30°C, in presence of thiamine diphosphate, in presence of 2 mM Ca2+
0.0006
pyruvate
-
cooperativity is observed, Hill coefficient is 1.6, pH 7.6, 37°C
0.0007
pyruvate
-
2-oxoglutarate dehydrogenase complex, pH 7.6, 30°C, in absence of thiamine diphosphate, in presence of 2 mM Mn2+
0.0016
pyruvate
-
2-oxoglutarate dehydrogenase complex, pH 7.6, 30°C, in absence of thiamine diphosphate, in presence of 2 mM Ca2+
0.0043
pyruvate
-
domestic pig, pH 7.5, temperature not specified in the publication
0.02
pyruvate
P08559; Q86SW4
patient with primary lactic acidaemia, pH 8.0, temperature not specified in the publication
0.023
pyruvate
-
2-oxoglutarate dehydrogenase complex, pH 7.6, 30°C, in presence of thiamine diphosphate, without divalent cations
0.053
pyruvate
-
pH not specified in the publication, temperature not specified in the publication
0.056
pyruvate
presence of 0.002 mM inhibitor N-((1-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-iodo-1H-1,2,3-triazol-4-yl)methyl)-4-nitrobenzenesulfonamide, pH 7.2, 37°C
0.063
pyruvate
-
2-oxoglutarate dehydrogenase complex, pH 7.6, 30°C, in absence of thiamine diphosphate and divalent cations
0.072
pyruvate
-
pH not specified in the publication, temperature not specified in the publication
0.123
pyruvate
-
absence of malate, pH 7.6, temperature not specified in the publication
0.128
pyruvate
-
presence of 1 mM malate, pH 7.6, temperature not specified in the publication
1
pyruvate
-
the complex displays cooperativity, Hill coefficient is 0.7, pH not specified in the publication, temperature not specified in the publication
0.00158
thiamine diphosphate
wild-type, Hill coefficient 1.38, pH 7.0, 30°C
0.00665
thiamine diphosphate
mutant Y177A, Hill coefficient 1.0, pH 7.0, 30°C
additional information
additional information
-
kinetic and thermodynamic analysis
-
additional information
additional information
-
kinetic study, reaction of pyruvate dehydrogenase complex
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