Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.16.2: tyrosine 3-monooxygenase

This is an abbreviated version!
For detailed information about tyrosine 3-monooxygenase, go to the full flat file.

Word Map on EC 1.14.16.2

Reaction

L-tyrosine
+
a 5,6,7,8-tetrahydropteridine
 +
O2
=
L-Dopa
 +
a 4a-hydroxy-5,6,7,8-tetrahydropteridine

Synonyms

CAT-2, DTH1, DTH2, hTH2, L-tyrosine hydroxylase, monophenol monooxygenase, oxygenase, tyrosine 3-mono-, TH, TH1, TH2, TyrH, tyrosinase, tyrosine 3-hydroxylase, tyrosine 3-monooxygenase, tyrosine hydroxylase, tyrosine hydroxylase type 1, tyrosine-3-mono-oxygenase, tyrosine-3-monooxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.2 tyrosine 3-monooxygenase

Expression

Expression on EC 1.14.16.2 - tyrosine 3-monooxygenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
20 mg/kg cocaine administration to neuronal nitric oxide synthase knockout mice significantly decreases striatal tyrosine hydroxylase expression
-
20 mg/kg cocaine administration to wild type mice significantly increases striatal tyrosine hydroxylase expression
-
administration of silver nanoparticles to pregnant rats in a time- and dose-dependent manner increases the expression levels of the enzyme in the brain of male and female pups at all tested days after birth
-
although minocycline increases tyrosine hydroxylase-immunoreactivity in glial cell line-derived neurotrophic factor+/- mice, it does not attenuate the methamphetamine-induced reduction of tyrosine hydroxylase
-
atipamezole and/or levodopa treatments do not clearly affect on the amount of tyrosine hydroxylasein the striatum
-
compared with the control group, the expression of enzyme mRNA in both sides of the brain tissue in Parkinson rats decreases during 8 weeks, and the expression of mRNA in the injured brain tissue is significantly lower than that in normal rats
-
during pupal metamorphosis, enzyme expression is upregulated during the late stage of development
enzyme activity in the adrenal medulla, heart, and hypothalamus in Nomega-nitro-L-arginine methyl ester-treated rats is significantly increased compared to the control
heterogeneous nuclear ribonucleoprotein K is a transactivator of enzyme transcription
in cercaria compared with the adult worm
-
long-term stress from hypoxia leads to induction of tyrosine hydroxylase mRNA and protein in adrenal medulla and brain, this induction is usually associated with stimulation of tyrosine hydroxylase gene transcription rate. Tyrosine hydroxylase mRNA increases 8fold at 3 h after immobilization of rats and remains elevated about 2fold after 24 h. Tyrosine hydroxylase gene transcription increases in response to nicotine or stress. cAMP is a powerful inducer of both tyrosine hydroxylase mRNA and protein.
-
methamphetamine induces reduction of tyrosine hydroxylase
-
neither forskolin, nor phorbol esters or stimulatory agonists like glutamate, neurotensin, muscarine, nicotine or pituitary adenylate cyclase-activating peptide reproducibly induce tyrosine hydroxylase mRNA in the midbrain. When midbrain slices are treated with 1 mM 8-(4-chlorophenylthio)-cAMP or 0.01 mM forskolin, there is no induction of tyrosine hydroxylase mRNA.
-
propolis, pollen, and caffeic acid phenethyl ester may mediate diminished enzyme activity in the heart, adrenal medulla, and hypothalamus in hypertensive rats
single administration of vitamin C (0.5 mM) or co-administration of vitamin C with vitamin E (1 mM) for 72 h highly upregulates tyrosine hydroxylase expression, while single vitamin E treatment does not show any statistically significant effect
-
striatal tyrosine hydroxylase shows a 49.8% reduction compared to control values in incidental Lewy body disease cases
-
the amount of tyrosine hydroxylase protein in the brain of sepiapterin reductase-null mice is less than 10% of wild type, while tyrosine hydroxylase protein in the adrenal gland is not altered
-
the enzyme is expressed in the epidermis during development or in the fat body after Beauveria bassiana infection
-
the initial stress stage (for 10 min at 30°C) is accompanied by an increase of the relative content of tyrosine hydroxylase-positive neurons in some central nervous system areas
tyrosine hydroxylase expression is unaffected by overexpression of wild type and phospho-mimic mutant alpha-synuclein (S129D)in dopaminergic MN9D cells, however, alpha-synuclein overexpression evidently inhibits TH phosphorylation at Ser40, while alpha-synuclein (S129D) mutant enhances phosphorylation
-