1.14.16.2: tyrosine 3-monooxygenase
This is an abbreviated version!
For detailed information about tyrosine 3-monooxygenase, go to the full flat file.
Word Map on EC 1.14.16.2
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1.14.16.2
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dopamine
-
dopaminergic
-
parkinsonism
-
nigra
-
striatum
-
catecholamine
-
substantia
-
nerve
-
ventral
-
fiber
-
sympathetic
-
innervation
-
adrenal
-
noradrenergic
-
neurotransmitter
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6-hydroxydopamine
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ganglia
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th-positive
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catecholaminergic
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neuropeptide
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norepinephrine
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nigrostriatal
-
midbrain
-
monoamine
-
neurotrophic
-
compacta
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coeruleus
-
hypothalamus
-
tegmental
-
mesencephalic
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1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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l-dopa
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6-ohda
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neurochemical
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accumbens
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noradrenaline
-
rostrally
-
dopac
-
apomorphine
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perikarya
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intrastriatal
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beta-hydroxylase
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mptp-induced
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varicosity
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ventrolateral
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dopamine-beta-hydroxylase
-
preoptic
-
npy
-
phenylethanolamine
-
analysis
-
diagnostics
-
homovanillic
-
synthesis
- 1.14.16.2
- dopamine
-
dopaminergic
- parkinsonism
- nigra
- striatum
- catecholamine
-
substantia
- nerve
-
ventral
- fiber
-
sympathetic
-
innervation
- adrenal
-
noradrenergic
-
neurotransmitter
- 6-hydroxydopamine
- ganglia
-
th-positive
-
catecholaminergic
-
neuropeptide
- norepinephrine
-
nigrostriatal
- midbrain
-
monoamine
-
neurotrophic
- compacta
- coeruleus
- hypothalamus
- tegmental
-
mesencephalic
- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- l-dopa
-
6-ohda
-
neurochemical
- accumbens
- noradrenaline
-
rostrally
-
dopac
- apomorphine
- perikarya
-
intrastriatal
- beta-hydroxylase
-
mptp-induced
-
varicosity
-
ventrolateral
- dopamine-beta-hydroxylase
-
preoptic
- npy
- phenylethanolamine
- analysis
- diagnostics
-
homovanillic
- synthesis
Reaction
Synonyms
CAT-2, DTH1, DTH2, hTH2, L-tyrosine hydroxylase, monophenol monooxygenase, oxygenase, tyrosine 3-mono-, TH, TH1, TH2, TyrH, tyrosinase, tyrosine 3-hydroxylase, tyrosine 3-monooxygenase, tyrosine hydroxylase, tyrosine hydroxylase type 1, tyrosine-3-mono-oxygenase, tyrosine-3-monooxygenase
ECTree
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Temperature Stability
Temperature Stability on EC 1.14.16.2 - tyrosine 3-monooxygenase
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37
40 - 65
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minimal aggregation occurs for wild type enzyme after heating at 40°C-45 for 60 min. A steep decrease in activity is observed between 40 and 65°C, and a complete loss of activity occurs at temperatures above 70°C
45
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in presence of 2% glycerol, enzymes lose activity in time-dependent manner
50
additional information
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thermal stability of hTH1 is increased by phosphorylation at Ser-40
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5 h, stable, catecholamine, N-methyl-norsalsolinol, or norsalsolinol binding increases the thermal stability of tyrosine hydroxylase
37
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unstable in presence of phosphatidylinositol or NaCl at high concentration, but relatively stable in presence of heparin
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half-life of activated, phosphorylated enzyme: 5 min, half-life of nonphosphorylated enzyme: 15 min
50
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50% loss of activity after 90 min, 80% loss of activity after 2 h, wild-type enzyme
50
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half-life of activated, phosphorylated enzyme: 5 min, half-life of nonphosphorylated enzyme: 15 min
50
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in presence of 10% glycerol, all mutant enzymes are stable for at least 1 h