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1.14.16.2: tyrosine 3-monooxygenase

This is an abbreviated version!
For detailed information about tyrosine 3-monooxygenase, go to the full flat file.

Word Map on EC 1.14.16.2

Reaction

L-tyrosine
+
a 5,6,7,8-tetrahydropteridine
+
O2
=
L-Dopa
+
a 4a-hydroxy-5,6,7,8-tetrahydropteridine

Synonyms

CAT-2, DTH1, DTH2, hTH2, L-tyrosine hydroxylase, monophenol monooxygenase, oxygenase, tyrosine 3-mono-, TH, TH1, TH2, TyrH, tyrosinase, tyrosine 3-hydroxylase, tyrosine 3-monooxygenase, tyrosine hydroxylase, tyrosine hydroxylase type 1, tyrosine-3-mono-oxygenase, tyrosine-3-monooxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.2 tyrosine 3-monooxygenase

Natural Substrates Products

Natural Substrates Products on EC 1.14.16.2 - tyrosine 3-monooxygenase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-tyrosine + (6R)-L-erythro-1',2'-dihydroxypropyltetrahydropterin + O2
?
show the reaction diagram
L-tyrosine + (6R)-L-erythro-tetrahydrobiopterin + O2
?
show the reaction diagram
-
probable regulatory role of cosubstrate for all 4 isoforms
-
-
?
L-tyrosine + tetrahydrobiopterin + O2
3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin + H2O
show the reaction diagram
L-tyrosine + tetrahydrobiopterin + O2
3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O
show the reaction diagram
L-tyrosine + tetrahydrobiopterin + O2
L-dopa + 4a-hydroxytetrahydrobiopterin + H2O
show the reaction diagram
L-tyrosine + tetrahydropteridine + O2
3,4-dihydroxyphenylalanine + dihydropteridine + H2O
show the reaction diagram
-
-
-
-
?
additional information
?
-