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1.14.16.2: tyrosine 3-monooxygenase

This is an abbreviated version!
For detailed information about tyrosine 3-monooxygenase, go to the full flat file.

Word Map on EC 1.14.16.2

Reaction

L-tyrosine
+
a 5,6,7,8-tetrahydropteridine
 +
O2
=
L-Dopa
 +
a 4a-hydroxy-5,6,7,8-tetrahydropteridine

Synonyms

CAT-2, DTH1, DTH2, hTH2, L-tyrosine hydroxylase, monophenol monooxygenase, oxygenase, tyrosine 3-mono-, TH, TH1, TH2, TyrH, tyrosinase, tyrosine 3-hydroxylase, tyrosine 3-monooxygenase, tyrosine hydroxylase, tyrosine hydroxylase type 1, tyrosine-3-mono-oxygenase, tyrosine-3-monooxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.16.2 tyrosine 3-monooxygenase

Localization

Localization on EC 1.14.16.2 - tyrosine 3-monooxygenase

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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
molecules phosphorylated at their Ser31 and Ser40 are localized predominantly in the cytoplasm of PC-12D cells
Manually annotated by BRENDA team
-
mutant enzymes T283M and R306H expressed in Escherichia coli are mainly found in inclusion bodies but a small amount of soluble enzyme is produced
Manually annotated by BRENDA team
-
particle-bound
Manually annotated by BRENDA team
-
molecules phosphorylated at Ser19 are found mainly in the nucleus
Manually annotated by BRENDA team
-
mutant enzyme T245P and T463 M expressed in Escherichia coli are predominantly soluble. Mutant enzymes T283M and R306H expressed in Escherichia coli are mainly found in inclusion bodies but a small amount of soluble enzyme is produced
-
Manually annotated by BRENDA team