1.13.11.11: tryptophan 2,3-dioxygenase
This is an abbreviated version!
For detailed information about tryptophan 2,3-dioxygenase, go to the full flat file.
Word Map on EC 1.13.11.11
-
1.13.11.11
-
indoleamine
-
kynurenine
-
immunotherapy
-
heme
-
serotonin
-
checkpoint
-
l-trp
-
n-formylkynurenine
-
quinolinic
-
tolerogenic
-
3-monooxygenase
-
3,4-dioxygenase
-
heme-containing
-
2,3-dioxygenase-1
-
tryptophan-degrading
-
3-hydroxyanthranilate
-
indoleamine-2,3-dioxygenase
-
picolinic
-
tryptophan-catabolizing
-
pyrrolase
-
3-hydroxykynurenine
-
medicine
-
drug development
- 1.13.11.11
- indoleamine
- kynurenine
-
immunotherapy
- heme
- serotonin
-
checkpoint
- l-trp
- n-formylkynurenine
-
quinolinic
-
tolerogenic
-
3-monooxygenase
-
3,4-dioxygenase
-
heme-containing
-
2,3-dioxygenase-1
-
tryptophan-degrading
- 3-hydroxyanthranilate
- indoleamine-2,3-dioxygenase
-
picolinic
-
tryptophan-catabolizing
-
pyrrolase
- 3-hydroxykynurenine
- medicine
- drug development
Reaction
Synonyms
33737, BRAFLDRAFT_210874, C28H8.11, EC 1.11.1.4, hTDO, IDO-1, IDO-2, IDO1, IDO2, indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2, TDO, TDO2, TDOa, tryptophan 2,3-dioxygenase, tryptophan 2,3-dioxygenase 2, tryptophan 2,3-dioxygenase-2, tryptophan-2,3-dioxygenase, v1g157887, vCG5163, XcTDO
ECTree
Advanced search results
Reference
Reference on EC 1.13.11.11 - tryptophan 2,3-dioxygenase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basran, J.; Booth, E.S.; Lee, M.; Handa, S.; Raven, E.L.
Analysis of reaction intermediates in tryptophan 2,3-dioxygenase a comparison with indoleamine 2,3-dioxygenase
Biochemistry
55
6743-6750
2016
Homo sapiens (P48775), Xanthomonas campestris pv. campestris (Q8PDA8), Xanthomonas campestris pv. campestris ATCC 33913 (Q8PDA8)
Maeta, A.; Sano, M.; Fukuwatari, T.; Funakoshi, H.; Nakamura, T.; Shibata, K.
Contributions of tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase to the conversion of D-tryptophan to nicotinamide analyzed by using tryptophan 2,3-dioxygenase-knockout mice
Biosci. Biotechnol. Biochem.
78
878-881
2014
Mus musculus (P48776), Mus musculus C57BL/6 (P48776)
Pantouris, G.; Loudon-Griffiths, J.; Mowat, C.G.
Insights into the mechanism of inhibition of tryptophan 2,3-dioxygenase by isatin derivatives
J. Enzyme Inhib. Med. Chem.
31
70-78
2016
Homo sapiens
Yuasa, H.J.; Ball, H.J.
Efficient tryptophan-catabolizing activity is consistently conserved through evolution of TDO enzymes, but not IDO enzymes
J. Exp. Zool. B
324
128-140
2015
no activity in Saccharomyces cerevisiae, no activity in Schistosoma mansoni, Strongylocentrotus purpuratus, no activity in Brugia malayi, Nematostella vectensis (A7RFF0), Monosiga brevicollis (A9V766), Branchiostoma floridae (C3XXE6), Drosophila melanogaster (P20351), Rattus norvegicus (P21643), Homo sapiens (P48775), Caenorhabditis elegans (Q09474)
Wu, J.S.; Lin, S.Y.; Liao, F.Y.; Hsiao, W.C.; Lee, L.C.; Peng, Y.H.; Hsieh, C.L.; Wu, M.H.; Song, J.S.; Yueh, A.; Chen, C.H.; Yeh, S.H.; Liu, C.Y.; Lin, S.Y.; Yeh, T.K.; Hsu, J.T.; Shih, C.; Ueng, S.H.; Hung, M.S.; Wu, S.Y.
Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening
J. Med. Chem.
58
7807-7819
2015
Homo sapiens (P48775)
Nienhaus, K.; Hahn, V.; Huepfel, M.; Nienhaus, G.U.
Substrate binding primes human tryptophan 2,3-dioxygenase for ligand binding
J. Phys. Chem. B
121
7412-7420
2017
Homo sapiens (P48775), Homo sapiens
Gonzalez Esquivel, D.; Ramirez-Ortega, D.; Pineda, B.; Castro, N.; Rios, C.; Perez de la Cruz, V.
Kynurenine pathway metabolites and enzymes involved in redox reactions
Neuropharmacology
112
331-345
2017
Homo sapiens (P14902), Homo sapiens (P48775), Homo sapiens (Q6ZQW0), Mus musculus (P28776), Xanthomonas campestris pv. campestris (Q8PDA8), Xanthomonas campestris pv. campestris ATCC 33913 (Q8PDA8)
Meng, B.; Wu, D.; Gu, J.; Ouyang, S.; Ding, W.; Liu, Z.
Structural and functional analyses of human tryptophan 2,3-dioxygenase
Proteins
82
3210-3216
2014
Homo sapiens (P48775), Homo sapiens
Lewis-Ballester, A.; Forouhar, F.; Kim, S.M.; Lew, S.; Wang, Y.; Karkashon, S.; Seetharaman, J.; Batabyal, D.; Chiang, B.Y.; Hussain, M.; Correia, M.A.; Yeh, S.R.; Tong, L.
Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase
Sci. Rep.
6
35169
2016
Homo sapiens (P48775), Homo sapiens
Pei, Z.; Mendonca, R.; Gazzard, L.; Pastor, R.; Goon, L.; Gustafson, A.; VanderPorten, E.; Hatzivassiliou, G.; Dement, K.; Cass, R.; Yuen, P.W.; Zhang, Y.; Wu, G.; Lin, X.; Liu, Y.; Sellers, B.D.
Aminoisoxazoles as potent inhibitors of tryptophan 2,3-dioxygenase 2 (TDO2)
ACS Med. Chem. Lett.
9
417-421
2018
Homo sapiens (P48775), Homo sapiens
Wei, Y.; Lu, C.; Jiang, S.; Zhang, Y.; Li, Q.; Bai, W.J.; Wang, X.
Directed evolution of a tryptophan 2,3-dioxygenase for the diastereoselective monooxygenation of tryptophans
Angew. Chem. Int. Ed. Engl.
59
3043-3047
2020
Xanthomonas campestris
Liu, Y.; Kim, S.M.; Wang, Y.; Karkashon, S.; Lewis-Ballester, A.; Yeh, S.R.; Correia, M.A.
Characterization of the structural determinants of the ubiquitin-dependent proteasomal degradation of human hepatic tryptophan 2,3-dioxygenase
Biochem. J.
478
1999-2017
2021
Homo sapiens (P48775), Homo sapiens
Geng, J.; Weitz, A.C.; Dornevil, K.; Hendrich, M.P.; Liu, A.
Kinetic and spectroscopic characterization of the catalytic ternary complex of tryptophan 2,3-dioxygenase
Biochemistry
59
2813-2822
2020
Cupriavidus metallidurans (Q1LK00), Cupriavidus metallidurans, Cupriavidus metallidurans ATCC 43123 (Q1LK00)
Zhang, S.; Guo, L.; Yang, D.; Xing, Z.; Li, W.; Kuang, C.; Yang, Q.
Evaluation and comparison of the commonly used bioassays of human indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO)
Bioorg. Chem.
104
104348
2020
Homo sapiens (P48775), Homo sapiens
Li, Y.; Zhang, S.; Wang, R.; Cui, M.; Liu, W.; Yang, Q.; Kuang, C.
Synthesis of novel tryptanthrin derivatives as dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase
Bioorg. Med. Chem. Lett.
30
127159
2020
Homo sapiens (P48775)
Chang, Y.; Han, P.; Wang, Y.; Jia, C.; Zhang, B.; Zhao, Y.; Li, S.; Li, S.; Wang, X.; Yang, X.; Wei, W.
Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis
Br. J. Pharmacol.
179
3024-3042
2022
Rattus norvegicus (P21643), Homo sapiens (P48775)
Boros, F.A.; Vecsei, L.
Tryptophan 2,3-dioxygenase, a novel therapeutic target for Parkinsons disease
Expert Opin. Ther. Targets
25
877-888
2021
Homo sapiens (P48775)
Basran, J.; Booth, E.S.; Campbell, L.P.; Thackray, S.J.; Jesani, M.H.; Clayden, J.; Moody, P.C.E.; Mowat, C.G.; Kwon, H.; Raven, E.L.
Binding of L-kynurenine to X. campestris tryptophan 2,3-dioxygenase
J. Inorg. Biochem.
225
111604
2021
Xanthomonas campestris, Xanthomonas campestris pv. campestris (Q8PDA8), Xanthomonas campestris pv. campestris ATCC 33913 (Q8PDA8)
Kozlova, A.; Thabault, L.; Liberelle, M.; Klaessens, S.; Prevost, J.R.C.; Mathieu, C.; Pilotte, L.; Stroobant, V.; Van den Eynde, B.; Frederick, R.
Rational design of original fused-cycle selective inhibitors of tryptophan 2,3-dioxygenase
J. Med. Chem.
64
10967-10980
2021
Homo sapiens (P48775)
Ning, X.L.; Li, Y.Z.; Huo, C.; Deng, J.; Gao, C.; Zhu, K.R.; Wang, M.; Wu, Y.X.; Yu, J.L.; Ren, Y.L.; Luo, Z.Y.; Li, G.; Chen, Y.; Wang, S.Y.; Peng, C.; Yang, L.L.; Wang, Z.Y.; Wu, Y.; Qian, S.; Li, G.B.
X-ray structure-guided discovery of a potent, orally bioavailable, dual human indoleamine/tryptophan 2,3-dioxygenase (hIDO/hTDO) inhibitor that shows activity in a mouse model of Parkinsons disease
J. Med. Chem.
64
8303-8332
2021
Homo sapiens (P48775), Homo sapiens
Huang, L.; Yao, W.; Wang, T.; Li, J.; He, Q.; Huang, F.
Acetylation of phenylalanine hydroxylase and tryptophan 2,3-dioxygenase alters hepatic aromatic amino acid metabolism in weaned piglets
Metabolites
10
146
2020
Sus scrofa (F1RWA8)
Sari, S.; Tomek, P.; Leung, E.; Reynisson, J.
Discovery and characterisation of dual inhibitors of tryptophan 2,3-dioxygenase (TDO2) and indoleamine 2,3-dioxygenase 1 (IDO1) using virtual screening
Molecules
24
4346
2019
Homo sapiens (P48775), Homo sapiens
Dolsak, A.; Gobec, S.; Sova, M.
Indoleamine and tryptophan 2,3-dioxygenases as important future therapeutic targets
Pharmacol. Ther.
221
107746
2021
Homo sapiens, Homo sapiens (P14902), Homo sapiens (Q6ZQW0)
Klaessens, S.; Stroobant, V.; Hoffmann, D.; Gyrd-Hansen, M.; Pilotte, L.; Vigneron, N.; De Plaen, E.; Van den Eynde, B.J.
Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase
Proc. Natl. Acad. Sci. USA
118
e2022447118
2021
Homo sapiens (P48775)
html completed