1.13.11.11: tryptophan 2,3-dioxygenase

This is an abbreviated version!
For detailed information about tryptophan 2,3-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.11

Reaction

L-tryptophan
+
O2
=
N-formyl-L-kynurenine

Synonyms

33737, BRAFLDRAFT_210874, C28H8.11, hTDO, IDO-1, IDO-2, TDO, TDO2, TDOa, v1g157887, vCG5163, XcTDO

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.11 tryptophan 2,3-dioxygenase

Reference

Reference on EC 1.13.11.11 - tryptophan 2,3-dioxygenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Basran, J.; Booth, E.S.; Lee, M.; Handa, S.; Raven, E.L.
Analysis of reaction intermediates in tryptophan 2,3-dioxygenase a comparison with indoleamine 2,3-dioxygenase
Biochemistry
55
6743-6750
2016
Homo sapiens (P48775), Xanthomonas campestris pv. campestris (Q8PDA8), Xanthomonas campestris pv. campestris ATCC 33913 (Q8PDA8)
Manually annotated by BRENDA team
Maeta, A.; Sano, M.; Fukuwatari, T.; Funakoshi, H.; Nakamura, T.; Shibata, K.
Contributions of tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase to the conversion of D-tryptophan to nicotinamide analyzed by using tryptophan 2,3-dioxygenase-knockout mice
Biosci. Biotechnol. Biochem.
78
878-881
2014
Mus musculus (P48776), Mus musculus C57BL/6 (P48776)
Manually annotated by BRENDA team
Pantouris, G.; Loudon-Griffiths, J.; Mowat, C.G.
Insights into the mechanism of inhibition of tryptophan 2,3-dioxygenase by isatin derivatives
J. Enzyme Inhib. Med. Chem.
31
70-78
2016
Homo sapiens
Manually annotated by BRENDA team
Yuasa, H.J.; Ball, H.J.
Efficient tryptophan-catabolizing activity is consistently conserved through evolution of TDO enzymes, but not IDO enzymes
J. Exp. Zool. B
324
128-140
2015
Branchiostoma floridae (C3XXE6), Caenorhabditis elegans (Q09474), Drosophila melanogaster (P20351), Homo sapiens (P48775), Monosiga brevicollis (A9V766), Nematostella vectensis (A7RFF0), no activity in Brugia malayi, no activity in Saccharomyces cerevisiae, no activity in Schistosoma mansoni, Rattus norvegicus (P21643), Strongylocentrotus purpuratus (W4ZI02)
Manually annotated by BRENDA team
Wu, J.S.; Lin, S.Y.; Liao, F.Y.; Hsiao, W.C.; Lee, L.C.; Peng, Y.H.; Hsieh, C.L.; Wu, M.H.; Song, J.S.; Yueh, A.; Chen, C.H.; Yeh, S.H.; Liu, C.Y.; Lin, S.Y.; Yeh, T.K.; Hsu, J.T.; Shih, C.; Ueng, S.H.; Hung, M.S.; Wu, S.Y.
Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening
J. Med. Chem.
58
7807-7819
2015
Homo sapiens (P48775)
Manually annotated by BRENDA team
Nienhaus, K.; Hahn, V.; Huepfel, M.; Nienhaus, G.U.
Substrate binding primes human tryptophan 2,3-dioxygenase for ligand binding
J. Phys. Chem. B
121
7412-7420
2017
Homo sapiens, Homo sapiens (P48775)
Manually annotated by BRENDA team
Gonzalez Esquivel, D.; Ramirez-Ortega, D.; Pineda, B.; Castro, N.; Rios, C.; Perez de la Cruz, V.
Kynurenine pathway metabolites and enzymes involved in redox reactions
Neuropharmacology
112
331-345
2017
Homo sapiens (P14902), Homo sapiens (P48775), Homo sapiens (Q6ZQW0), Mus musculus (P28776), Xanthomonas campestris pv. campestris (Q8PDA8), Xanthomonas campestris pv. campestris ATCC 33913 (Q8PDA8)
Manually annotated by BRENDA team
Meng, B.; Wu, D.; Gu, J.; Ouyang, S.; Ding, W.; Liu, Z.
Structural and functional analyses of human tryptophan 2,3-dioxygenase
Proteins
82
3210-3216
2014
Homo sapiens, Homo sapiens (P48775)
Manually annotated by BRENDA team
Lewis-Ballester, A.; Forouhar, F.; Kim, S.M.; Lew, S.; Wang, Y.; Karkashon, S.; Seetharaman, J.; Batabyal, D.; Chiang, B.Y.; Hussain, M.; Correia, M.A.; Yeh, S.R.; Tong, L.
Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase
Sci. Rep.
6
35169
2016
Homo sapiens, Homo sapiens (P48775)
Manually annotated by BRENDA team