1.13.11.11: tryptophan 2,3-dioxygenase

This is an abbreviated version!
For detailed information about tryptophan 2,3-dioxygenase, go to the full flat file.

Reaction

Synonyms

33737, BRAFLDRAFT_210874, C28H8.11, EC 1.11.1.4, hTDO, IDO-1, IDO-2, IDO1, IDO2, indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2, TDO, TDO2, TDOa, tryptophan 2,3-dioxygenase, tryptophan 2,3-dioxygenase 2, tryptophan 2,3-dioxygenase-2, tryptophan-2,3-dioxygenase, v1g157887, vCG5163, XcTDO

ECTree

     1 Oxidoreductases

         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

             1.13.11 With incorporation of two atoms of oxygen

                1.13.11.11 tryptophan 2,3-dioxygenase

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Results	in table
2	Activating Compound
9810	AA Sequence
2	Application
14	Cloned(Commentary)
18	Cofactor
4	Crystallization (Commentary)
1191	Disease/ Diagnostics
4	Expression
54	General Information
4	General Stability
135	IC50 Value
146	Inhibitors
26	KM Value [mM]
1	Localization
4	Metals/Ions
3	Molecular Weight [Da]
39	Natural Substrates/ Products (Substrates)
55	Organism
9	Pathway
85	PDB ID
9	pH Optimum
3	Posttranslational Modification
24	Protein Variants
5	Purification (Commentary)
3	Reaction
45	Reference
63	Source Tissue
60	Substrates and Products (Substrate)
9	Subunits
64	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
8	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 1.13.11.11 - tryptophan 2,3-dioxygenase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

D-tryptophan + O2

N-formyl-D-kynurenine

2 entries

L-tryptophan + O2

N-formyl-L-kynurenine

25 entries

additional information

?

-

2 entries

D-tryptophan + O2

N-formyl-D-kynurenine

Mus musculus

P48776

low activity

742114

-

-

?

D-tryptophan + O2

N-formyl-D-kynurenine

Mus musculus C57BL/6

P48776

low activity

742114

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Branchiostoma floridae

C3XXE6

-

743005

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Caenorhabditis elegans

Q09474

-

743005

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Cupriavidus metallidurans

Q1LK00

-

764174

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Cupriavidus metallidurans ATCC 43123

Q1LK00

-

764174

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Drosophila melanogaster

P20351

-

743005

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Homo sapiens

P14902, Q6ZQW0

-

765516

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Homo sapiens

P48775

-

741938, 743005, 743064, 743153

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Homo sapiens

-

-

743153

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Homo sapiens

P48775

-

743760, 743821

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Homo sapiens

-

-

743821

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Homo sapiens

P48775

-

763817, 764108

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Homo sapiens

-

-

764108

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Homo sapiens

P48775

-

764267, 764295, 764645, 765225, 765422

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Homo sapiens

-

-

765422

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Homo sapiens

P48775

-

765688, 765754

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Monosiga brevicollis

A9V766

-

743005

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Mus musculus

P48776

-

742114

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Mus musculus C57BL/6

P48776

-

742114

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Nematostella vectensis

A7RFF0

-

743005

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Rattus norvegicus

P21643

-

743005, 764385

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Strongylocentrotus purpuratus

-

-

743005

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Sus scrofa

F1RWA8

-

765327

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Xanthomonas campestris

-

-

763893, 765204

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Xanthomonas campestris pv. campestris

Q8PDA8

-

741938, 765204

-

-

?

L-tryptophan + O2

N-formyl-L-kynurenine

Xanthomonas campestris pv. campestris ATCC 33913

Q8PDA8

-

765204, 741938

-

-

?

additional information

?

-

Mus musculus

P48776

in mouse liver homogenate, TDO activity is five times lower for D-Trp than that for L-Trp. L-Trp is the preferred substrate for nicotinamide synthesis because L-Trp metabolism is more efficient than D-Trp in mice

742114

-

-

?

additional information

?

-

Mus musculus C57BL/6

P48776

in mouse liver homogenate, TDO activity is five times lower for D-Trp than that for L-Trp. L-Trp is the preferred substrate for nicotinamide synthesis because L-Trp metabolism is more efficient than D-Trp in mice

742114

-

-

?