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Literature summary for 1.13.11.11 extracted from

  • Geng, J.; Weitz, A.C.; Dornevil, K.; Hendrich, M.P.; Liu, A.
    Kinetic and spectroscopic characterization of the catalytic ternary complex of tryptophan 2,3-dioxygenase (2020), Biochemistry, 59, 2813-2822 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Cupriavidus metallidurans
-
 N-formyl-L-kynurenine
-
 ?
L-tryptophan + O2 Cupriavidus metallidurans ATCC 43123
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Cupriavidus metallidurans Q1LK00
-
-
Cupriavidus metallidurans ATCC 43123 Q1LK00
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
 Cupriavidus metallidurans N-formyl-L-kynurenine
-
 ?
L-tryptophan + O2 kinetic and spectroscopic characterization of the catalytic ternary complex of tryptophan 2,3-dioxygenase Cupriavidus metallidurans N-formyl-L-kynurenine
-
 ?
L-tryptophan + O2
-
 Cupriavidus metallidurans ATCC 43123 N-formyl-L-kynurenine
-
 ?
L-tryptophan + O2 kinetic and spectroscopic characterization of the catalytic ternary complex of tryptophan 2,3-dioxygenase Cupriavidus metallidurans ATCC 43123 N-formyl-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
TDO
-
 Cupriavidus metallidurans

Cofactor

Cofactor Comment Organism Structure
heme heme-dependent dioxygenase Cupriavidus metallidurans

General Information

General Information Comment Organism
physiological function the first step of the kynurenine pathway for L-tryptophan (L-Trp) degradation is catalyzed by heme-dependent dioxygenases, tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase Cupriavidus metallidurans