1.13.11.11: tryptophan 2,3-dioxygenase

This is an abbreviated version!
For detailed information about tryptophan 2,3-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.11

Reaction

L-tryptophan
+
O2
=
N-formyl-L-kynurenine

Synonyms

33737, BRAFLDRAFT_210874, C28H8.11, hTDO, IDO-1, IDO-2, TDO, TDO2, TDOa, v1g157887, vCG5163, XcTDO

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.11 tryptophan 2,3-dioxygenase

Cloned

Cloned on EC 1.13.11.11 - tryptophan 2,3-dioxygenase

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CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
gene 33737, DNA and amino acid sequence determination and analysis, sequence and genetic structure comparisons, and phylogenetic analysis, functional complementation of the enzyme-deficient Saccharomyces cerevisiae
gene BRAFLDRAFT_210874, DNA and amino acid sequence determination and analysis, sequence and genetic structure comparisons, and phylogenetic analysis, functional complementation of the enzyme-deficient Saccharomyces cerevisiae
gene C28H8.11, DNA and amino acid sequence determination and analysis, sequence and genetic structure comparisons, and phylogenetic analysis, functional complementation of the enzyme-deficient Saccharomyces cerevisiae
gene kynA, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)
-
gene TDO, DNA and amino acid sequence determination and analysis, sequence and genetic structure comparisons, and phylogenetic analysis, functional complementation of the enzyme-deficient Saccharomyces cerevisiae
gene TDO, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)
-
gene TDO2, recombinant expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)
-
gene TDOa, DNA and amino acid sequence determination and analysis, sequence and genetic structure comparisons, and phylogenetic analysis, functional complementation of the enzyme-deficient Saccharomyces cerevisiae
gene v1g157887, DNA and amino acid sequence determination and analysis, sequence and genetic structure comparisons, and phylogenetic analysis, recombinant expression of His6-tagged enzyme in Escherichia coli strain KRX, functional complementation of the enzyme-deficient Saccharomyces cerevisiae
gene vCG5163, DNA and amino acid sequence determination and analysis, sequence and genetic structure comparisons, and phylogenetic analysis, functional complementation of the enzyme-deficient Saccharomyces cerevisiae
recombinant expression of full-length His6-tagged hTDO protein in human liver HepG2 cell culture
-
recombinant expression of N-terminally His6-tagged wild-type and mutant enzymes in Escherichia coli BL21(DE3)
-