Disease on EC 1.13.11.11 - tryptophan 2,3-dioxygenase

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DISEASE
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Abortion, Habitual
Role of Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase in Patients with Recurrent Miscarriage.
Adenocarcinoma
Assessment of TILs, IDO-1, and PD-L1 in resected non-small cell lung cancer: an immunohistochemical study with clinicopathological and prognostic implications.
Indoleamine-2,3-Dioxygenase in Non-Small Cell Lung Cancer: A Targetable Mechanism of Immune Resistance Frequently Coexpressed With PD-L1.
Adenocarcinoma of Lung
Assessment of TILs, IDO-1, and PD-L1 in resected non-small cell lung cancer: an immunohistochemical study with clinicopathological and prognostic implications.
Alzheimer Disease
Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's disease brain.
Asthma
Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases.
Tryptophan Metabolism in Allergic Disorders.
Brain Neoplasms
The kynurenine pathway in brain tumor pathogenesis.
Breast Neoplasms
Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway.
TDO2 Overexpression Is Associated with Cancer Stem Cells and Poor Prognosis in Esophageal Squamous Cell Carcinoma.
Carcinogenesis
Indoleamine Dioxygenase Inhibitors: Clinical Rationale and Current Development.
Carcinoma
Differential expression and significance of PD-L1, IDO-1 and B7-H4 in human lung cancer.
High IDO-1 Expression in Tumor Endothelial Cells is Associated with Response to Immunotherapy in Metastatic Renal Cell Carcinoma.
Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment.
Subcutaneous inoculation position affects the immune environment in CT26 carcinomas.
Carcinoma, Adenosquamous
Indoleamine-2,3-Dioxygenase in Non-Small Cell Lung Cancer: A Targetable Mechanism of Immune Resistance Frequently Coexpressed With PD-L1.
Carcinoma, Hepatocellular
Intestine-Specific Homeobox Gene ISX Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression.
Carcinoma, Medullary
Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment.
Carcinoma, Non-Small-Cell Lung
Assessment of TILs, IDO-1, and PD-L1 in resected non-small cell lung cancer: an immunohistochemical study with clinicopathological and prognostic implications.
Differential expression and significance of PD-L1, IDO-1 and B7-H4 in human lung cancer.
Investigation of indolamine 2, 3 dioxygenase (IDO-1) gene expression by real-time PCR among patients with lung cancer.
Carcinoma, Renal Cell
High IDO-1 Expression in Tumor Endothelial Cells is Associated with Response to Immunotherapy in Metastatic Renal Cell Carcinoma.
Colitis
Induction of IDO-1 by immunostimulatory DNA limits severity of experimental colitis.
Colorectal Neoplasms
Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers.
Dermatitis, Atopic
Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases.
Endometriosis
IL-1? Increases Expression of Tryptophan 2,3-dioxygenase and Stimulates Tryptophan Catabolism in Endometrioma Stromal Cells.
Glioma
Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors.
Involvement of the kynurenine pathway in human glioma pathophysiology.
Glucose Intolerance
Comparison of effects of nicotinic acid or tryptophan on tryptophan 2,3-dioxygenase in acute and chronic studies.
Hypertension
The activation of the kynurenine pathway in a rat model with renovascular hypertension.
indoleamine 2,3-dioxygenase deficiency
Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl4-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation.
Infections
Benzo[b]quinolizinium Derivatives Have a Strong Antimalarial Activity and Inhibit Indoleamine Dioxygenase.
Loss of Th22 cells is associated with increased immune activation and IDO-1 activity in HIV-1 infection.
M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection.
Tryptophan 2,3-dioxygenase activity in turkey poults infected with Bordetella avium.
Insulin Resistance
Attenuation of high sucrose diet-induced insulin resistance in tryptophan 2,3-dioxygenase deficient Drosophila melanogaster vermilion mutants.
Leukemia, Myeloid, Acute
A novel immunohistochemical score to predict early mortality in acute myeloid leukemia patients based on indoleamine 2,3 dioxygenase expression.
Lung Neoplasms
Assessment of TILs, IDO-1, and PD-L1 in resected non-small cell lung cancer: an immunohistochemical study with clinicopathological and prognostic implications.
Differential expression and significance of PD-L1, IDO-1 and B7-H4 in human lung cancer.
Discovery of Tryptanthrin Derivatives as Potent Inhibitors of Indoleamine 2, 3-Dioxygenase with Therapeutic Activity in LLC tumor-bearing Mice.
Indoleamine-2,3-Dioxygenase in Non-Small Cell Lung Cancer: A Targetable Mechanism of Immune Resistance Frequently Coexpressed With PD-L1.
Investigation of indolamine 2, 3 dioxygenase (IDO-1) gene expression by real-time PCR among patients with lung cancer.
Lymphoma, T-Cell, Cutaneous
Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas.
Malaria
Purification and biochemical characterization of a recombinant Anopheles gambiae tryptophan 2,3-dioxygenase expressed in Escherichia coli.
Malaria, Cerebral
Benzo[b]quinolizinium Derivatives Have a Strong Antimalarial Activity and Inhibit Indoleamine Dioxygenase.
Meningioma
Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas.
Nasal Polyps
Functional role of kynurenine and aryl hydrocarbon receptor axis in chronic rhinosinusitis with nasal polyps.
Neoplasm Metastasis
Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention.
Neoplasms
4,6-Substituted-1H-Indazoles as potent IDO1/TDO dual inhibitors.
Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers.
Antitumour agents as inhibitors of tryptophan 2,3-dioxygenase.
Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase reveals insights into substrate recognition and catalytic mechanism.
Differential expression and significance of PD-L1, IDO-1 and B7-H4 in human lung cancer.
Discovery of Tryptanthrin Derivatives as Potent Inhibitors of Indoleamine 2, 3-Dioxygenase with Therapeutic Activity in LLC tumor-bearing Mice.
Fluorine-18-Labeled PET Radiotracers for Imaging Tryptophan Uptake and Metabolism: a Systematic Review.
Heme enzyme patterns in genetically and chemically induced mouse liver tumors.
Heme enzyme patterns in rat liver nodules and tumors.
High IDO-1 Expression in Tumor Endothelial Cells is Associated with Response to Immunotherapy in Metastatic Renal Cell Carcinoma.
Immunoactivative role of indoleamine 2,3-dioxygenase in human hepatocellular carcinoma.
Indoleamine Dioxygenase Inhibitors: Clinical Rationale and Current Development.
Indoleamine-2,3-Dioxygenase in Non-Small Cell Lung Cancer: A Targetable Mechanism of Immune Resistance Frequently Coexpressed With PD-L1.
Inhibition of indoleamine 2,3-dioxygenase activity by fatty acids and prostaglandins: A structure function analysis.
Investigation of indolamine 2, 3 dioxygenase (IDO-1) gene expression by real-time PCR among patients with lung cancer.
Involvement of the kynurenine pathway in human glioma pathophysiology.
Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment.
Melatonin in cancer patients and in tumor-bearing animals.
Novel indoleamine 2,3-dioxygenase-1 inhibitors from a multistep in silico screen.
OKN-007 Increases temozolomide (TMZ) Sensitivity and Suppresses TMZ-Resistant Glioblastoma (GBM) Tumor Growth.
Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention.
Pt(IV) hybrids containing a TDO inhibitor serve as potential anticancer immunomodulators.
Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme.
Self-Amplified Drug Delivery with Light-Inducible Nanocargoes to Enhance Cancer Immunotherapy.
Serial transplants of DMBA-induced mammary tumors in Fischer rats as a model system for human breast cancer. VI. The role of different forms of tumor-associated stress for the regulation of pineal melatonin secretion.
Targeting the Inhibition of Tryptophan 2,3-Dioxygenase (TDO-2) for Cancer Treatment.
TDO2 Overexpression Is Associated with Cancer Stem Cells and Poor Prognosis in Esophageal Squamous Cell Carcinoma.
The Interactions Between Kynurenine, Folate, Methionine and Pteridine Pathways in Obesity.
The kynurenine pathway in brain tumor pathogenesis.
The next-generation BET inhibitor, PLX51107, delays melanoma growth in a CD8-mediated manner.
The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by ?-PD-L1 or ?-IL6 antibodies.
Tryptophan 2,3-Dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators.
Tryptophan 2,3-dioxygenase (TDO)-reactive T cells differ in their functional characteristics in health and cancer.
Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives.
Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma.
Tumoral Immune Resistance Mediated by Enzymes That Degrade Tryptophan.
Nervous System Diseases
Ameliorative effect of fisetin against lipopolysaccharide and restraint stress-induced behavioral deficits via modulation of NF-?B and IDO-1.
Neurodegenerative Diseases
Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives.
Obesity
Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy.
Obesity, Maternal
Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy.
Papillomavirus Infections
Indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase expression in HPV infection, SILs, and cervical cancer.
Porphyrias
Effects of acute carbamazepine administration on haem metabolism in rat liver.
Porphyrias, Hepatic
Hypothesis: Metabolic targeting of 5-aminolevulinate synthase by tryptophan and inhibitors of heme utilisation by tryptophan 2,3-dioxygenase as potential therapies of acute hepatic porphyrias.
Rhabdomyolysis
Free heme pool and activity of key enzyme of heme synthesis in the rat liver under action of agents affecting reduced glutathione level.
Rhinitis, Allergic
Neopterin Levels and Indoleamine 2,3-Dioxygenase Activity as Biomarkers of Immune System Activation and Childhood Allergic Diseases.
Tryptophan Metabolism in Allergic Disorders.
Starvation
Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers.
The influence of starvation and tryptophan administration on the metabolism of phenylalanine, tyrosine and tryptophan in isolated rat liver cells.
Tourette Syndrome
Exon and intron variants in the human tryptophan 2,3-dioxygenase gene: potential association with Tourette syndrome, substance abuse and other disorders.
tryptophan 2,3-dioxygenase deficiency
Hypertryptophanemia due to tryptophan 2,3-dioxygenase deficiency.
Tuberculosis
M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection.
Uterine Cervical Neoplasms
Indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase expression in HPV infection, SILs, and cervical cancer.
Vitamin B 6 Deficiency
The effect of pyridoxine deficiency on the metabolism of the aromatic amino acids by isolated rat liver cells.
Zika Virus Infection
Transcriptional Changes during Naturally Acquired Zika Virus Infection Render Dendritic Cells Highly Conducive to Viral Replication.