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Literature summary for 1.13.11.11 extracted from

  • Hutchinson, A.P.; Yin, P.; Neale, I.; Coon, J.S.; Kujawa, S.A.; Liu, S.; Bulun, S.E.
    Tryptophan 2,3-dioxygenase-2 in uterine Leiomyoma dysregulation by MED12 mutation status (2022), Reprod. Sci., 29, 743-749 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P48775
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leiomyoma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
TDO2
-
 Homo sapiens
tryptophan 2,3-dioxygenase-2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens TDO2 gene expression is upregulated in leiomyoma expressing mut-MED12. The tissue mRNA levels of tryptophan 2,3-dioxygenase (TDO2), the rate limiting enzyme of tryptophan metabolism through the kynurenine pathway, is 36fold higher in leiomyomas expressing mutated mediator complex subunit 12 (mut-MED12) compared to adjacent myometrium, and 14fold higher compared to wild type-MED12 leiomyoma up

General Information

General Information Comment Organism
physiological function rate limiting enzyme of tryptophan metabolism Homo sapiens
physiological function TDO2 is the key enzyme responsible for reduced tryptophan levels in mut-MED12 leiomyoma Homo sapiens