Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(cyclopropylmethyl)-5-(1H-indol-3-yl)-1H-benzotriazole | - |
Homo sapiens | |
1-(cyclopropylmethyl)-6-(1H-indol-3-yl)-1H-benzotriazole | - |
Homo sapiens | |
2-[5-(1H-indol-3-yl)-1H-benzotriazol-1-yl]-N,N-dimethylethan-1-amine | - |
Homo sapiens | |
2-[5-(1H-indol-3-yl)-1H-benzotriazol-1-yl]acetamide | - |
Homo sapiens | |
2-[6-(1H-indol-3-yl)-1H-benzotriazol-1-yl]-N,N-dimethylethan-1-amine | - |
Homo sapiens | |
2-[6-(1H-indol-3-yl)-1H-benzotriazol-1-yl]acetamide | - |
Homo sapiens | |
3-[5-(1H-indol-3-yl)-1H-benzotriazol-1-yl]propane-1,2-diol | - |
Homo sapiens | |
3-[6-(1H-indol-3-yl)-1H-benzotriazol-1-yl]propane-1,2-diol | - |
Homo sapiens | |
5-(1H-indol-3-yl)-1-(2,2,2-trifluoroethyl)-1H-benzotriazole | - |
Homo sapiens | |
5-(1H-indol-3-yl)-1-methyl-1H-benzotriazol-4-amine | - |
Homo sapiens | |
5-(1H-indol-3-yl)-1-methyl-1H-benzotriazole | - |
Homo sapiens | |
5-(1H-indol-3-yl)-1-[(oxolan-2-yl)methyl]-1H-benzotriazole | - |
Homo sapiens | |
5-(1H-indol-3-yl)-1-[(oxolan-3-yl)methyl]-1H-benzotriazole | - |
Homo sapiens | |
5-(1H-indol-3-yl)-1-[(piperidin-4-yl)methyl]-1H-benzotriazole | - |
Homo sapiens | |
5-(1H-indol-3-yl)-1-[2-(morpholin-4-yl)ethyl]-1H-benzotriazole | - |
Homo sapiens | |
5-(1H-indol-3-yl)-1-[2-(piperazin-1-yl)ethyl]-1H-benzotriazole | - |
Homo sapiens | |
5-(1H-indol-3-yl)-1-[2-(pyrrolidin-3-yl)ethyl]-1H-benzotriazole | - |
Homo sapiens | |
5-(1H-indol-3-yl)-2-methyl-2H-benzotriazol-4-amine | - |
Homo sapiens | |
5-(1H-indol-3-yl)-2-methyl-2H-benzotriazole | - |
Homo sapiens | |
5-(6-fluoro-1H-indol-3-yl)-1-methyl-1H-benzotriazole | - |
Homo sapiens | |
5-(6-fluoro-1H-indol-3-yl)-1-[2-(piperazin-1-yl)ethyl]-1H-benzotriazole | - |
Homo sapiens | |
6-(1H-indol-3-yl)-1-(2,2,2-trifluoroethyl)-1H-benzotriazole | - |
Homo sapiens | |
6-(1H-indol-3-yl)-1-methyl-1H-benzotriazol-7-amine | - |
Homo sapiens | |
6-(1H-indol-3-yl)-1-methyl-1H-[1,2,3]triazolo[4,5-b]pyridine | - |
Homo sapiens | |
6-(1H-indol-3-yl)-1-methyl-7-nitro-1H-benzotriazole | - |
Homo sapiens | |
6-(1H-indol-3-yl)-1-[(oxolan-2-yl)methyl]-1H-benzotriazole | - |
Homo sapiens | |
6-(1H-indol-3-yl)-1-[(oxolan-3-yl)methyl]-1H-benzotriazole | - |
Homo sapiens | |
6-(1H-indol-3-yl)-1-[(piperidin-4-yl)methyl]-1H-benzotriazole | - |
Homo sapiens | |
6-(1H-indol-3-yl)-1-[(pyrrolidin-3-yl)methyl]-1H-benzotriazole | - |
Homo sapiens | |
6-(1H-indol-3-yl)-1-[2-(morpholin-4-yl)ethyl]-1H-benzotriazole | - |
Homo sapiens | |
6-(1H-indol-3-yl)-1-[2-(piperazin-1-yl)ethyl]-1H-benzotriazole | - |
Homo sapiens | |
6-(1H-indol-3-yl)-1H-benzotriazole | - |
Homo sapiens | |
6-(1H-indol-3-yl)-2-methyl-2H-[1,2,3]triazolo[4,5-b]pyridine | - |
Homo sapiens | |
6-(1H-indol-3-yl)-3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine | - |
Homo sapiens | |
6-(1H-indol-3-yl)isoquinoline | - |
Homo sapiens | |
6-(1H-indol-3-yl)quinazoline | - |
Homo sapiens | |
6-fluoro-3-[(E)-2-(1H-tetrazol-5-yl)ethenyl]-1H-indole | - |
Homo sapiens | |
6-fluoro-3-[(E)-2-(pyridin-3-yl)ethenyl]-1H-indole | - |
Homo sapiens | |
7-(1H-indol-3-yl)-3,4-dihydroquinazolin-2(1H)-one | - |
Homo sapiens | |
7-(1H-indol-3-yl)isoquinoline | - |
Homo sapiens | |
7-(1H-indol-3-yl)quinazoline | - |
Homo sapiens | |
[5-(1H-indol-3-yl)-1H-benzotriazol-1-yl]acetic acid | - |
Homo sapiens | |
[6-(1H-indol-3-yl)-1H-benzotriazol-1-yl]acetic acid | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | Homo sapiens | - |
N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P48775 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TDO2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | heme-containing enzyme | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00068 | - |
37°C, pH 6.28 | Homo sapiens | 2-[6-(1H-indol-3-yl)-1H-benzotriazol-1-yl]acetamide | |
0.0011 | - |
37°C, pH 6.14 | Homo sapiens | 5-(6-fluoro-1H-indol-3-yl)-1-methyl-1H-benzotriazole | |
0.00132 | - |
37°C, pH 6.22 | Homo sapiens | 6-(1H-indol-3-yl)-1-methyl-7-nitro-1H-benzotriazole | |
0.00162 | - |
37°C, pH 6.27 | Homo sapiens | 2-[5-(1H-indol-3-yl)-1H-benzotriazol-1-yl]acetamide | |
0.0019 | - |
37°C, pH 6.24 | Homo sapiens | 6-(1H-indol-3-yl)-1-(2,2,2-trifluoroethyl)-1H-benzotriazole | |
0.002 | 0.0034 | 37°C, pH 6.11 | Homo sapiens | 6-(1H-indol-3-yl)-1H-benzotriazole | |
0.00385 | - |
37°C, pH 6.16 | Homo sapiens | 5-(1H-indol-3-yl)-2-methyl-2H-benzotriazol-4-amine | |
0.00387 | - |
37°C, pH 6.13 | Homo sapiens | 5-(1H-indol-3-yl)-1-methyl-1H-benzotriazole | |
0.0039 | - |
37°C, pH 6.26 | Homo sapiens | 1-(cyclopropylmethyl)-6-(1H-indol-3-yl)-1H-benzotriazole | |
0.00393 | - |
37°C, pH 6.18 | Homo sapiens | 6-(1H-indol-3-yl)-1-methyl-1H-benzotriazol-7-amine | |
0.004 | - |
37°C, pH 6.12 | Homo sapiens | 5-(1H-indol-3-yl)-2-methyl-2H-benzotriazole | |
0.0049 | 0.0066 | 37°C, pH 6.7 | Homo sapiens | 6-(1H-indol-3-yl)isoquinoline | |
0.00501 | - |
37°C, pH 6.17 | Homo sapiens | 5-(1H-indol-3-yl)-1-methyl-1H-benzotriazol-4-amine | |
0.0052 | - |
37°C, pH 6.45 | Homo sapiens | 6-(1H-indol-3-yl)-1-[2-(piperazin-1-yl)ethyl]-1H-benzotriazole | |
0.0056 | 0.0071 | 37°C, pH 6.6 | Homo sapiens | 7-(1H-indol-3-yl)isoquinoline | |
0.00602 | - |
37°C, pH 6.15 | Homo sapiens | 6-(1H-indol-3-yl)-1H-benzotriazole | |
0.0061 | 0.0087 | 37°C, pH 6.5 | Homo sapiens | 6-fluoro-3-[(E)-2-(1H-tetrazol-5-yl)ethenyl]-1H-indole | |
0.00783 | - |
37°C, pH 6.20 | Homo sapiens | 6-(1H-indol-3-yl)-3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridine | |
0.00908 | - |
37°C, pH 6.21 | Homo sapiens | 6-(1H-indol-3-yl)-1-methyl-1H-[1,2,3]triazolo[4,5-b]pyridine | |
0.0127 | 0.0229 | 37°C, pH 6.10 | Homo sapiens | 7-(1H-indol-3-yl)-3,4-dihydroquinazolin-2(1H)-one | |
0.0128 | 0.0169 | 37°C, pH 6.8 | Homo sapiens | 6-(1H-indol-3-yl)quinazoline | |
0.01306 | - |
37°C, pH 6.19 | Homo sapiens | 6-(1H-indol-3-yl)-2-methyl-2H-[1,2,3]triazolo[4,5-b]pyridine | |
0.0135 | - |
37°C, pH 6.25 | Homo sapiens | 1-(cyclopropylmethyl)-5-(1H-indol-3-yl)-1H-benzotriazole | |
0.015 | - |
37°C, pH 6.23 | Homo sapiens | 5-(1H-indol-3-yl)-1-(2,2,2-trifluoroethyl)-1H-benzotriazole | |
0.017 | - |
37°C, pH 6.46 | Homo sapiens | 3-[5-(1H-indol-3-yl)-1H-benzotriazol-1-yl]propane-1,2-diol | |
0.01773 | - |
37°C, pH 6.39 | Homo sapiens | 5-(1H-indol-3-yl)-1-[(piperidin-4-yl)methyl]-1H-benzotriazole | |
0.0211 | - |
37°C, pH 6.36 | Homo sapiens | 6-(1H-indol-3-yl)-1-[(oxolan-2-yl)methyl]-1H-benzotriazole | |
0.0212 | 0.0326 | 37°C, pH 6.9 | Homo sapiens | 7-(1H-indol-3-yl)quinazoline | |
0.0219 | - |
37°C, pH 6.34 | Homo sapiens | 6-(1H-indol-3-yl)-1-[(oxolan-3-yl)methyl]-1H-benzotriazole | |
0.0246 | - |
37°C, pH 6.32 | Homo sapiens | 2-[6-(1H-indol-3-yl)-1H-benzotriazol-1-yl]-N,N-dimethylethan-1-amine | |
0.0249 | - |
37°C, pH 6.43 | Homo sapiens | 5-(1H-indol-3-yl)-1-[2-(piperazin-1-yl)ethyl]-1H-benzotriazole | |
0.0252 | - |
37°C, pH 6.47 | Homo sapiens | 3-[6-(1H-indol-3-yl)-1H-benzotriazol-1-yl]propane-1,2-diol | |
0.02551 | - |
37°C, pH 6.40 | Homo sapiens | 6-(1H-indol-3-yl)-1-[(piperidin-4-yl)methyl]-1H-benzotriazole | |
0.0261 | - |
37°C, pH 6.41 | Homo sapiens | 5-(1H-indol-3-yl)-1-[2-(pyrrolidin-3-yl)ethyl]-1H-benzotriazole | |
0.0369 | - |
37°C, pH 6.31 | Homo sapiens | 2-[5-(1H-indol-3-yl)-1H-benzotriazol-1-yl]-N,N-dimethylethan-1-amine | |
0.0369 | - |
37°C, pH 6.35 | Homo sapiens | 5-(1H-indol-3-yl)-1-[(oxolan-2-yl)methyl]-1H-benzotriazole | |
0.0441 | - |
37°C, pH 6.33 | Homo sapiens | 5-(1H-indol-3-yl)-1-[(oxolan-3-yl)methyl]-1H-benzotriazole | |
0.045 | - |
37°C, pH 6.44 | Homo sapiens | 5-(6-fluoro-1H-indol-3-yl)-1-[2-(piperazin-1-yl)ethyl]-1H-benzotriazole | |
0.04565 | - |
37°C, pH 6.42 | Homo sapiens | 6-(1H-indol-3-yl)-1-[(pyrrolidin-3-yl)methyl]-1H-benzotriazole | |
0.0526 | - |
37°C, pH 6.38 | Homo sapiens | 6-(1H-indol-3-yl)-1-[2-(morpholin-4-yl)ethyl]-1H-benzotriazole | |
0.1045 | - |
37°C, pH 6.30 | Homo sapiens | [6-(1H-indol-3-yl)-1H-benzotriazol-1-yl]acetic acid | |
0.1186 | - |
37°C, pH 6.37 | Homo sapiens | 5-(1H-indol-3-yl)-1-[2-(morpholin-4-yl)ethyl]-1H-benzotriazole | |
0.1738 | - |
37°C, pH 6.29 | Homo sapiens | [5-(1H-indol-3-yl)-1H-benzotriazol-1-yl]acetic acid |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is responsible for L-tryptophan (L-Trp) homeostasis. Expression of TDO2 in cancer cells results in the inhibition of immune-mediated tumor rejection due to an enhancement of L-Trp catabolism via the kynurenine pathway | Homo sapiens |