1.10.5.1: ribosyldihydronicotinamide dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about ribosyldihydronicotinamide dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.10.5.1

Reaction

1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide
+
a quinone
=
1-(beta-D-ribofuranosyl)nicotinamide
+
a quinol

Synonyms

bQR2, dihydronicotinamide riboside:quinone oxidoreductase, dihydronicotinamide riboside:quinone oxidoreductase 2, dihydronicotinamide riboside:quinone reductase 2, EC 1.10.99.2, melatonin-binding site MT3, MT3, MT3/NQO2, N-ribosyldihydronicotinamide dehydrogenase (quinone), N-ribosyldihydronicotinamide:quinone oxidoreductase 2, NQO2, NRH-oxidizing enzyme, NRH:QR2, NRH:quinone oxidoreductase, NRH:quinone oxidoreductase 2, NRH:quinone oxireductase 2, NRH:quinone reductase 2, QR2, quinone oxidoreductase 2, quinone reductase 2, quinone reductase type 2

ECTree

     1 Oxidoreductases
         1.10 Acting on diphenols and related substances as donors
             1.10.5 With a quinone or related compound as acceptor
                1.10.5.1 ribosyldihydronicotinamide dehydrogenase (quinone)

IC50 Value

IC50 Value on EC 1.10.5.1 - ribosyldihydronicotinamide dehydrogenase (quinone)

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0182
1,4-dimethylquinolin-2(1H)-one
Homo sapiens
-
23C
0.00087
2-(2-methoxy-6H-pyrido[2',3':4,5]pyrrolo[2,1-a]isoindol-11-yl)ethylamine
Homo sapiens
-
IC50: 0.00087 mM
0.016
2-iodo-melatonin
Homo sapiens
-
IC50: 0.016 mM
0.0011
2-iodomelatonin
Homo sapiens
-
pH 8, 25C
0.0108
5,6,8-trimethoxy-1,4-dimethylquinolin-2(1H)-one
Homo sapiens
-
23C
0.006
5,6,8-trimethoxy-4-methylquinolin-2(1H)-one
Homo sapiens
-
23C
0.0041
5,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one
Homo sapiens
-
23C
0.0108
5,8-dimethoxy-4-methylquinolin-2(1H)-one
Homo sapiens
-
23C
0.001833
5-(2-(dimethylamino)ethylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.000167
5-(2-(dimethylamino)ethylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one N-oxide
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.001483
5-(2-(dimethylamino)ethylamino)-8-bromo-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.000117
5-(2-(dimethylamino)ethylamino)-8-bromo-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one N-oxide
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.000783
5-(2-(dimethylamino)ethylamino)-8-fluoro-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.001333
5-(2-(dimethylamino)ethylamino)-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.000098
5-(2-(dimethylamino)ethylamino)-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one N-oxide
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.000483
5-(3-hydroxypropylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.000987
5-(3-hydroxypropylamino)-8-bromo-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.000517
5-(3-hydroxypropylamino)-8-methoxy-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.000098
5-(4-methoxyphenylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.000427
5-(isopentylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.000567
5-(phenethylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.00034
5-hydroxyflavone
Homo sapiens
-
IC50: 340 nM
0.0539
5-hydroxytryptamine
Homo sapiens
-
pH 8, 25C
0.295
5-methoxy-carbonylamino-N-acetyltryptamine
Homo sapiens
-
IC50: 0.295 mM
0.000099
5-[[4-(diethylamino)butyl]amino]-10-methoxy-6H-imidazo[4,5,1-de]acridin-6-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000427
5-[[4-(diethylamino)butyl]amino]-6H-imidazo[4,5,1-de]acridin-6-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000017
5-[[4-(diethylamino)butyl]amino]-7,10-dimethoxy-6H-imidazo[4,5,1-de]acridin-6-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000031
5-[[4-(diethylamino)butyl]amino]-7-hydroxy-10-methoxy-6H-imidazo[4,5,1-de]acridin-6-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000006
5-[[4-(diethylamino)butyl]amino]-7-hydroxy-8,9-dimethoxy-6H-imidazo[4,5,1-de]acridin-6-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000016
5-[[4-(diethylamino)butyl]amino]-8-hydroxy-1-methyl-6H-imidazo[4,5,1-de]acridin-6-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000148
5-[[4-(diethylamino)butyl]amino]-8-hydroxy-6H-imidazo[4,5,1-de]acridin-6-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000009
5-[[4-(diethylamino)butyl]amino]-8-methoxy-1-methyl-6H-imidazo[4,5,1-de]acridin-6-one
Homo sapiens
-
pH and temperature not specified in the publication
0.001
5-[[4-(diethylamino)butyl]amino]-8-methoxy-6H-imidazo[4,5,1-de]acridin-6-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000953
5-[[4-(diethylamino)butyl]amino]-9-hydroxy-6H-imidazo[4,5,1-de]acridin-6-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000693
5-[[4-(dimethylamino)butyl]amino]-1-ethyl-6H-imidazo[4,5,1-de]acridin-6-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000323
5-[[4-(dimethylamino)butyl]amino]-1-methyl-6H-imidazo[4,5,1-de]acridin-6-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00083
5-[[4-(dimethylamino)butyl]amino]-6H-imidazo[4,5,1-de]acridin-6-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00005
5-[[4-(dimethylamino)butyl]amino]-8-hydroxy-1-methyl-6H-imidazo[4,5,1-de]acridin-6-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000296
5-[[4-(dimethylamino)butyl]amino]-8-hydroxy-6H-imidazo[4,5,1-de]acridin-6-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000597
5-[[6-(diethylamino)hexyl]amino]-8-hydroxy-6H-imidazo[4,5,1-de]acridin-6-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000172
5-[[6-(dimethylamino)hexyl]amino]-6H-imidazo[4,5,1-de]acridin-6-one
Homo sapiens
-
pH and temperature not specified in the publication
0.007
6,7,8-trimethoxy-1,4-dimethylquinolin-2(1H)-one
Homo sapiens
-
23C
0.01
6,7,8-trimethoxy-4-methylquinolin-2(1H)-one
Homo sapiens
-
23C
0.0019
6,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one
Homo sapiens
-
23C
0.0088
6,8-dimethoxy-4-methylquinolin-2(1H)-one
Homo sapiens
-
23C
0.0062
6,9-dimethyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one
Homo sapiens
-
23C
0.0541
6-methoxy-9-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one
Homo sapiens
-
23C
0.0108
6-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one
Homo sapiens
-
23C
0.0093
7,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one
Homo sapiens
-
23C
0.0293
7,8-dimethoxy-4-methylquinolin-2(1H)-one
Homo sapiens
-
23C
0.000767
8-bromo-5-[(3-methylbutyl)amino]-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0058
8-methoxy-1,4-dimethylquinolin-2(1H)-one
Homo sapiens
-
23C
0.0241
8-methoxy-4-methylquinolin-2(1H)-one
Homo sapiens
-
23C
0.00035
8-methoxy-5-(phenethylamino)-6H-[1,2,3]triazolo[4,5,1-de]acridin-6-one
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.00043
apigenin
Homo sapiens
-
IC50: 430 nM
0.0013
chrysin-dimethylether
Homo sapiens
-
IC50: 0.0013 mM
0.000016 - 0.00082
chrysoeriol
0.06
dabigatran
Homo sapiens
-
pH and temperature not specified in the publication
0.0008
dabigatran ethyl ester
Homo sapiens
-
pH and temperature not specified in the publication
0.59
dicoumarol
Homo sapiens
-
IC50: 0.59 mM
0.00086
isorhamnetin
Homo sapiens
-
IC50: 860 nM
0.00038
kaempferol
Homo sapiens
-
IC50: 380 nM
0.00078
luteolin
Homo sapiens
-
IC50: 780 nM
0.0028 - 0.13
Melatonin
0.015
methyl-1-(2-acetamidoethyl)-7-naphthylcarbamate
Homo sapiens
-
IC50: 0.015 mM
0.0099
N-acetyl-5-hydroxytryptamine
Homo sapiens
-
pH 8, 25C
0.099
N-acetylserotonin
Homo sapiens
-
IC50: 0.099 mM
0.0003
N-[2-(2-iodo-5-methoxy-1-methyl-4-nitroindol-3-yl)ethyl]acetamide
Homo sapiens
-
inhibits enzymatic mechanism of the enzyme through the MT3 binding site, IC50: 0.0003 mM
0.000014
N-[2-(2-methoxy-6H-dipyrido[2,3-a:3,2-e]pyrrolizin-11-yl)ethyl]-2-furamide
Homo sapiens
-
IC50: 14 nM
0.0002
N-[2-(2-methoxy-6H-pyrido[2',3':4,5]pyrrolo[2,1-a]isoindol-11-yl)ethyl]2-furamide
Homo sapiens
-
IC50: 0.0002 mM
0.0015
N-[2-(5-methoxy-4-nitro-1H-indol-3-yl)ethyl]acetamide
Homo sapiens
-
IC50: 0.0015 mM
0.044
N-[2-(5-methoxy-7-nitro-1H-indol-3-yl)ethyl]acetamide
Homo sapiens
-
IC50: 0.044 mM
0.038
N-[2-(7-methylaminosulfonyl-1-naphthyl)ethyl]acetamide
Homo sapiens
-
IC50: 0.038 mM
0.005
N-[2-(8-methoxy-3,4-dihydro-2H-pyrido[2',3':4,5]pyrrolo[2,1-b][1,3]oxazin-10-yl)ethyl]-2-furamide
Homo sapiens
-
IC50: 0.005 mM
0.0019
N1-[2-(2-methoxy-6H-pyrido[2',3':4,5]pyrrolo[2,1-a]isoindol-11-yl)ethyl]-acetamide
Homo sapiens
-
IC50: 0.0019 mM
0.0039
NSC106080
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0033
NSC115890
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.002
NSC180969
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0015
NSC187208
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0027
NSC204996
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0019
NSC238146
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0075
NSC27296
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.005
NSC300853
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0062
NSC306843
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.02
NSC332172
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0018
NSC356819
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0014
NSC356820
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.006
NSC359466
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.015
NSC381864
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.022
NSC623234
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.00005
NSC637991
Homo sapiens
-
pH and temperature not specified in the publication
0.000016
NSC637992
Homo sapiens
-
pH and temperature not specified in the publication
0.000009
NSC637993
Homo sapiens
-
pH and temperature not specified in the publication
0.000597
NSC637994
Homo sapiens
-
pH and temperature not specified in the publication
0.0038
NSC640353
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.006
NSC640556
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0058
NSC640558
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0065
NSC640559
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0053
NSC640566
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0032
NSC640583
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0049
NSC640584
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.000296
NSC645808
Homo sapiens
-
pH and temperature not specified in the publication
0.000148
NSC645809
Homo sapiens
-
pH and temperature not specified in the publication
0.000953
NSC645811
Homo sapiens
-
pH and temperature not specified in the publication
0.001
NSC645812
Homo sapiens
-
pH and temperature not specified in the publication
0.000427
NSC645831
Homo sapiens
-
pH and temperature not specified in the publication
0.00083
NSC645833
Homo sapiens
-
pH and temperature not specified in the publication
0.000323
NSC645834
Homo sapiens
-
pH and temperature not specified in the publication
0.000693
NSC645835
Homo sapiens
-
pH and temperature not specified in the publication
0.000172
NSC645836
Homo sapiens
-
pH and temperature not specified in the publication
0.0035
NSC649091
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.000099
NSC660838
Homo sapiens
-
pH and temperature not specified in the publication
0.000017
NSC660839
Homo sapiens
-
pH and temperature not specified in the publication
0.000031
NSC660840
Homo sapiens
-
pH and temperature not specified in the publication
0.000006
NSC660841
Homo sapiens
-
pH and temperature not specified in the publication
0.0058
NSC66167
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0096
NSC665126
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.002
NSC669977
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0097
NSC676468
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0029
NSC677939
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0017
NSC693571
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.005
NSC720622
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0018
NSC77833
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0021
NSC78017
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0055
NSC78021
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0021
NSC86715
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0027
NSC97374
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0051
NSC99495
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.006
NSC99528
Homo sapiens
-
in 50 mM phosphate buffer at pH 7.4, at 37C
0.0014
quercetin
Homo sapiens
-
IC50: 0.0014 mM
0.0015
quercetin-3-O-beta-glucopyranosyl
Homo sapiens
-
IC50: 0.0015 mM
0.000129 - 0.07
resveratrol
0.0012 - 0.0151
S26695
0.00091
S28128
Homo sapiens
-
IC50: 0.00091 mM
0.0000007 - 0.000079
S29434