Disease on EC 1.10.5.1 - ribosyldihydronicotinamide dehydrogenase (quinone)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Agranulocytosis
Genetic risk factors for clozapine-induced neutropenia and agranulocytosis in a Dutch psychiatric population.
Alzheimer Disease
Expression of Quinone Reductase-2 in the Cortex Is a Muscarinic Acetylcholine Receptor-Dependent Memory Consolidation Constraint.
Increased hippocampal quinone reductase 2 in Alzheimer's disease.
Amnesia
Loss of quinone reductase 2 function selectively facilitates learning behaviors.
Breast Neoplasms
Functional Polymorphisms, Altered Gene Expression and Genetic Association Link NRH:Quinone Oxidoreductase 2 to Breast Cancer with Wild-type p53.
Synthesis of carbon-11-labeled casimiroin analogues as new potential PET agents for imaging of quinone reductase 2 and aromatase expression in breast cancer.
Carcinogenesis
Deficiency of NRH:quinone oxidoreductase 2 increases susceptibility to 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene-induced skin carcinogenesis.
Nuclear factor Nrf2 and antioxidant response element regulate NRH:quinone oxidoreductase 2 (NQO2) gene expression and antioxidant induction.
Null association of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility and prognosis of Esophageal cancer in north Indian population and meta-analysis.
Leukemia
Mechanism-based inhibition of quinone reductase 2 (NQO2): selectivity for NQO2 over NQO1 and structural basis for flavoprotein inhibition.
The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2).
Lymphoma, B-Cell
NRH:quinone oxidoreductase 2-deficient mice are highly susceptible to radiation-induced B-cell lymphomas.
Retraction: NRH:Quinone Oxidoreductase 2-Deficient Mice Are Highly Susceptible to Radiation-induced B-Cell Lymphomas.
Malaria
Mechanism-based inhibition of quinone reductase 2 (NQO2): selectivity for NQO2 over NQO1 and structural basis for flavoprotein inhibition.
Melanoma
Inhibition of melanoma cell proliferation by resveratrol is correlated with upregulation of quinone reductase 2 and p53.
Neoplasm Metastasis
NRH:quinone oxidoreductase 2 (NQO2) and glutaminase (GLS) both play a role in large extracellular vesicles (LEV) formation in preclinical LNCaP-C4-2B prostate cancer model of progressive metastasis.
Neoplasms
Bioactive compounds from the fern Lepisorus contortus.
Crystal structure of quinone reductase 2 in complex with cancer prodrug CB1954.
Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer.
Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1).
In silico screening reveals structurally diverse, nanomolar inhibitors of NQO2 that are functionally active in cells and can modulate NF-?B signaling.
Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata.
NAD(P)H: quinone oxidoreductase 1 and NRH:quinone oxidoreductase 2 polymorphisms in papillary thyroid microcarcinoma: correlation with phenotype.
Non-symmetrical furan-amidines as novel leads for the treatment of cancer and malaria.
NRH:quinone oxidoreductase 2 and NAD(P)H:quinone oxidoreductase 1 protect tumor suppressor p53 against 20s proteasomal degradation leading to stabilization and activation of p53.
Resveratrol: Biological and pharmaceutical properties as anticancer molecule.
Retraction: NRH:Quinone Oxidoreductase 2 and NAD(P)H:Quinone Oxidoreductase 1 Protect Tumor Suppressor p53 against 20S Proteasomal Degradation Leading to Stabilization and Activation of p53.
SALMON: solvent accessibility, ligand binding, and mapping of ligand orientation by NMR spectroscopy.
Thiol-Based Probe for Electrophilic Natural Products Reveals That Most of the Ammosamides Are Artifacts.
Nervous System Diseases
Quinone reductase 2 is a catechol quinone reductase.
Neurodegenerative Diseases
Non-symmetrical furan-amidines as novel leads for the treatment of cancer and malaria.
Ovarian Neoplasms
NAD(P)H:quinone oxidoreductase 1 and nrh:quinone oxidoreductase 2 activity and expression in bladder and ovarian cancer and lower NRH:quinone oxidoreductase 2 activity associated with an NQO2 exon 3 single-nucleotide polymorphism.
Parkinson Disease
Association of NRH:quinone oxidoreductase 2 gene promoter polymorphism with higher gene expression and increased susceptibility to Parkinson's disease.
Quinone reductase 2 is a catechol quinone reductase.
Sp3 repression of polymorphic human NRH:quinone oxidoreductase 2 gene promoter.
Prostatic Neoplasms
Control of stability of cyclin D1 by quinone reductase 2 in CWR22Rv1 prostate cancer cells.
NRH:quinone oxidoreductase 2 (NQO2) and glutaminase (GLS) both play a role in large extracellular vesicles (LEV) formation in preclinical LNCaP-C4-2B prostate cancer model of progressive metastasis.