BRENDA - Enzyme Database show
show all sequences of 1.10.5.1

In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2)

Nolan, K.A.; Caraher, M.C.; Humphries, M.P.; Bettley, H.A.; Bryce, R.A.; Stratford, I.J.; Bioorg. Med. Chem. Lett. 20, 7331-7336 (2010)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
NSC106080
i.e. bis(2-hydroxyphenyl)methanone phenylhydrazone
Homo sapiens
NSC115890
i.e. 1,3-naphthalenediol
Homo sapiens
NSC180969
i.e. 7,8-dimethoxy-4-(3,4,5-trimethoxyphenyl)-1,2-dihydro-3H-benzo[e]isoindol-3-one
Homo sapiens
NSC187208
i.e. N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine, chloroquine
Homo sapiens
NSC204996
i.e. 7,8-dimethoxy-4-(3,4,5-trimethoxyphenyl)-2,3-dihydro-1H-benzo[e]isoindole
Homo sapiens
NSC238146
i.e. N4-(6-((6-amino-2-methyl-4-quinolinyl)amino)hexyl)-2-methyl-4,6-quinolinediamine acetate
Homo sapiens
NSC27296
i.e. N4-(6-methoxy-8-quinolinyl)-1,4-pentanediamine, primaquine
Homo sapiens
NSC300853
i.e. 3-amino-9-ethyl-2-((4-(hydroxy(oxido)amino)phenyl)diazenyl)-9H-carbazole
Homo sapiens
NSC306843
i.e. 1-methyl-4(1H)-quinolinone (1-methyl-4(1H)-quinolinylidene)hydrazone
Homo sapiens
NSC332172
i.e. 2-(4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile
Homo sapiens
NSC356819
i.e. 4-((2-hydroxy-5-(phenyldiazenyl)phenyl)diazenyl)benzenecarboximidamide
Homo sapiens
NSC356820
i.e. 4-((2-hydroxy-5-(2-phenylvinyl)phenyl)diazenyl)benzenecarboximidamide
Homo sapiens
NSC359466
i.e. 4-((4-(amino(imino)methyl)phenyl)diazenyl)-3-hydroxy-N-phenyl-2-naphthamide
Homo sapiens
NSC381864
i.e. 5-(2-(3,5-dimethoxyphenyl)vinyl)-2-methoxyphenol
Homo sapiens
NSC621351
i.e. 2-(2-fluorophenyl)-4-(2-naphthyl)-2,3-dihydro-1,5-benzothiazepine
Homo sapiens
NSC623234
i.e. 3-chloro-3-(3,4-dimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylaldehyde
Homo sapiens
NSC640353
i.e. 1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-4-methyl-5-phenyl-2,4-pentadien-1-one
Homo sapiens
NSC640556
i.e. 1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-3-(4-(hydroxy(oxido)amino)phenyl)-2-propen-1-one
Homo sapiens
NSC640558
i.e 1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-3-phenyl-2-propen-1-one
Homo sapiens
NSC640559
i.e. 1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-3-(3-(hydroxy(oxido)amino)phenyl)-2-propen-1-one
Homo sapiens
NSC640566
i.e. 3-(4-chlorophenyl)-1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-2-propen-1-one
Homo sapiens
NSC640583
i.e. 1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-3-(4-methylphenyl)-2-propen-1-one
Homo sapiens
NSC640584
i.e. 3-(3,4-dichlorophenyl)-1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-2-propen-1-one
Homo sapiens
NSC648420
i.e. 1,2,3-trimethoxyphenanthro[2,3-d][1,3]dioxol-6-yl acetate
Homo sapiens
NSC648422
i.e. 5-(1-methyl-2-(3,4,5-trimethoxyphenyl)vinyl)-1,3-benzodioxole
Homo sapiens
NSC649091
i.e. 2-((diethylamino)methyl)-4-((10-methyl-10H-indolo[3,2-b]quinolin-11-yl)amino)phenol hydrochloride
Homo sapiens
NSC65069
i.e. [1,1'-biphenyl]-2,3',4,5',6-pentol
Homo sapiens
NSC660841
one of the most potent inhibitors of NQO2
Homo sapiens
NSC66167
i.e. [1,1'-biphenyl]-2,2',4,4'-tetrol
Homo sapiens
NSC665126
i.e. 1-(2-(4-(hydroxy(oxido)amino)phenyl)vinyl)-3-phenylbenzo[f]quinoline
Homo sapiens
NSC669977
i.e. 6-imino-1-methyl-3-phenyl-2,6-dihydro-5(1H)-quinolinone hydrazone
Homo sapiens
NSC676468
i.e. N-(3-([1,10-biphenyl]-4-ylimino)-1-propenyl)[1,10-biphenyl]-4-amine
Homo sapiens
NSC677939
i.e. 14H-diindolo[2,3-a:3,2-h]quinolizine
Homo sapiens
NSC693571
i.e. trifluoromethanesulfonic acid compound with N,N-dimethyl-4-((1-methyl-2-phenyl-4H-1lambda5-pyrazolo[1,5-a]indol-4-ylidene)methyl)aniline
Homo sapiens
NSC720622
i.e. trifluoromethanesulfonic acid compound with N,N-dimethyl-4-((1-methyl-6-nitro-2-phenylpyrazolo[1,5-a]indol-1-ium-4-ylidene)methyl)aniline
Homo sapiens
NSC77833
i.e. 1-(2-(1H-indol-3-yl)vinyl)isoquinoline
Homo sapiens
NSC78017
i.e. 2,6-dimethyl-3H-pyrrolo[3,2-f]quinoline
Homo sapiens
NSC78021
i.e. 4,7-dimethyl-7H-pyrido[2,3-c]carbazole
Homo sapiens
NSC86715
i.e. 5-methyl-1-phenyl-6H-pyrido[4,3-b]carbazole
Homo sapiens
NSC97374
i.e. 1-ethyl-2-((1-ethyl-2(1H)-quinolinylidene)methyl)-1lambda5-quinoline
Homo sapiens
NSC99495
i.e. 3-benzo[a]anthracen-12-ylthiophene
Homo sapiens
NSC99528
i.e. 2-benzo[a]anthracen-12-yl-1-benzothiophene
Homo sapiens
quercetin
-
Homo sapiens
resveratrol
-
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
N-benzyldihydronicotinamide + 2,6-dichlorophenolindophenol
-
711432
Homo sapiens
N-benzylnicotinamide + reduced 2,6-dichlorophenolindophenol
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
FAD
-
Homo sapiens
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.0014
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC356820
0.0015
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC187208
0.0017
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC693571
0.0018
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC356819
0.0018
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC77833
0.0019
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC238146
0.002
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC180969
0.002
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC669977
0.0021
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC78017
0.0021
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC86715
0.0027
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC204996
0.0027
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC97374
0.0029
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC677939
0.0032
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC640583
0.0033
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC115890
0.0035
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC649091
0.0038
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC640353
0.0039
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC106080
0.0049
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC640584
0.005
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC300853
0.005
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC720622
0.0051
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC99495
0.0053
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC640566
0.0055
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC78021
0.0058
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC640558
0.0058
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC66167
0.006
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC359466
0.006
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC640556
0.006
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC99528
0.0062
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC306843
0.0065
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC640559
0.0075
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC27296
0.0096
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC665126
0.0097
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC676468
0.015
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC381864
0.02
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC332172
0.022
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC623234
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
FAD
-
Homo sapiens
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.0014
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC356820
0.0015
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC187208
0.0017
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC693571
0.0018
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC356819
0.0018
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC77833
0.0019
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC238146
0.002
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC180969
0.002
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC669977
0.0021
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC78017
0.0021
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC86715
0.0027
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC204996
0.0027
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC97374
0.0029
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC677939
0.0032
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC640583
0.0033
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC115890
0.0035
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC649091
0.0038
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC640353
0.0039
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC106080
0.0049
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC640584
0.005
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC300853
0.005
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC720622
0.0051
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC99495
0.0053
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC640566
0.0055
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC78021
0.0058
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC640558
0.0058
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC66167
0.006
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC359466
0.006
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC640556
0.006
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC99528
0.0062
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC306843
0.0065
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC640559
0.0075
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC27296
0.0096
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC665126
0.0097
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC676468
0.015
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC381864
0.02
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC332172
0.022
-
in 50 mM phosphate buffer at pH 7.4, at 37°C
Homo sapiens
NSC623234
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
NSC106080
i.e. bis(2-hydroxyphenyl)methanone phenylhydrazone
Homo sapiens
NSC115890
i.e. 1,3-naphthalenediol
Homo sapiens
NSC180969
i.e. 7,8-dimethoxy-4-(3,4,5-trimethoxyphenyl)-1,2-dihydro-3H-benzo[e]isoindol-3-one
Homo sapiens
NSC187208
i.e. N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine, chloroquine
Homo sapiens
NSC204996
i.e. 7,8-dimethoxy-4-(3,4,5-trimethoxyphenyl)-2,3-dihydro-1H-benzo[e]isoindole
Homo sapiens
NSC238146
i.e. N4-(6-((6-amino-2-methyl-4-quinolinyl)amino)hexyl)-2-methyl-4,6-quinolinediamine acetate
Homo sapiens
NSC27296
i.e. N4-(6-methoxy-8-quinolinyl)-1,4-pentanediamine, primaquine
Homo sapiens
NSC300853
i.e. 3-amino-9-ethyl-2-((4-(hydroxy(oxido)amino)phenyl)diazenyl)-9H-carbazole
Homo sapiens
NSC306843
i.e. 1-methyl-4(1H)-quinolinone (1-methyl-4(1H)-quinolinylidene)hydrazone
Homo sapiens
NSC332172
i.e. 2-(4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile
Homo sapiens
NSC356819
i.e. 4-((2-hydroxy-5-(phenyldiazenyl)phenyl)diazenyl)benzenecarboximidamide
Homo sapiens
NSC356820
i.e. 4-((2-hydroxy-5-(2-phenylvinyl)phenyl)diazenyl)benzenecarboximidamide
Homo sapiens
NSC359466
i.e. 4-((4-(amino(imino)methyl)phenyl)diazenyl)-3-hydroxy-N-phenyl-2-naphthamide
Homo sapiens
NSC381864
i.e. 5-(2-(3,5-dimethoxyphenyl)vinyl)-2-methoxyphenol
Homo sapiens
NSC621351
i.e. 2-(2-fluorophenyl)-4-(2-naphthyl)-2,3-dihydro-1,5-benzothiazepine
Homo sapiens
NSC623234
i.e. 3-chloro-3-(3,4-dimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acrylaldehyde
Homo sapiens
NSC640353
i.e. 1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-4-methyl-5-phenyl-2,4-pentadien-1-one
Homo sapiens
NSC640556
i.e. 1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-3-(4-(hydroxy(oxido)amino)phenyl)-2-propen-1-one
Homo sapiens
NSC640558
i.e 1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-3-phenyl-2-propen-1-one
Homo sapiens
NSC640559
i.e. 1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-3-(3-(hydroxy(oxido)amino)phenyl)-2-propen-1-one
Homo sapiens
NSC640566
i.e. 3-(4-chlorophenyl)-1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-2-propen-1-one
Homo sapiens
NSC640583
i.e. 1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-3-(4-methylphenyl)-2-propen-1-one
Homo sapiens
NSC640584
i.e. 3-(3,4-dichlorophenyl)-1-(2-(3,5-diphenyl-1H-pyrazol-1-yl)-4-methyl-1,3-thiazol-5-yl)-2-propen-1-one
Homo sapiens
NSC648420
i.e. 1,2,3-trimethoxyphenanthro[2,3-d][1,3]dioxol-6-yl acetate
Homo sapiens
NSC648422
i.e. 5-(1-methyl-2-(3,4,5-trimethoxyphenyl)vinyl)-1,3-benzodioxole
Homo sapiens
NSC649091
i.e. 2-((diethylamino)methyl)-4-((10-methyl-10H-indolo[3,2-b]quinolin-11-yl)amino)phenol hydrochloride
Homo sapiens
NSC65069
i.e. [1,1'-biphenyl]-2,3',4,5',6-pentol
Homo sapiens
NSC660841
one of the most potent inhibitors of NQO2
Homo sapiens
NSC66167
i.e. [1,1'-biphenyl]-2,2',4,4'-tetrol
Homo sapiens
NSC665126
i.e. 1-(2-(4-(hydroxy(oxido)amino)phenyl)vinyl)-3-phenylbenzo[f]quinoline
Homo sapiens
NSC669977
i.e. 6-imino-1-methyl-3-phenyl-2,6-dihydro-5(1H)-quinolinone hydrazone
Homo sapiens
NSC676468
i.e. N-(3-([1,10-biphenyl]-4-ylimino)-1-propenyl)[1,10-biphenyl]-4-amine
Homo sapiens
NSC677939
i.e. 14H-diindolo[2,3-a:3,2-h]quinolizine
Homo sapiens
NSC693571
i.e. trifluoromethanesulfonic acid compound with N,N-dimethyl-4-((1-methyl-2-phenyl-4H-1lambda5-pyrazolo[1,5-a]indol-4-ylidene)methyl)aniline
Homo sapiens
NSC720622
i.e. trifluoromethanesulfonic acid compound with N,N-dimethyl-4-((1-methyl-6-nitro-2-phenylpyrazolo[1,5-a]indol-1-ium-4-ylidene)methyl)aniline
Homo sapiens
NSC77833
i.e. 1-(2-(1H-indol-3-yl)vinyl)isoquinoline
Homo sapiens
NSC78017
i.e. 2,6-dimethyl-3H-pyrrolo[3,2-f]quinoline
Homo sapiens
NSC78021
i.e. 4,7-dimethyl-7H-pyrido[2,3-c]carbazole
Homo sapiens
NSC86715
i.e. 5-methyl-1-phenyl-6H-pyrido[4,3-b]carbazole
Homo sapiens
NSC97374
i.e. 1-ethyl-2-((1-ethyl-2(1H)-quinolinylidene)methyl)-1lambda5-quinoline
Homo sapiens
NSC99495
i.e. 3-benzo[a]anthracen-12-ylthiophene
Homo sapiens
NSC99528
i.e. 2-benzo[a]anthracen-12-yl-1-benzothiophene
Homo sapiens
quercetin
-
Homo sapiens
resveratrol
-
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
N-benzyldihydronicotinamide + 2,6-dichlorophenolindophenol
-
711432
Homo sapiens
N-benzylnicotinamide + reduced 2,6-dichlorophenolindophenol
-
-
-
?
Other publictions for EC 1.10.5.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
742815
Riches
The ontogeny and population v ...
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J. Biochem. Mol. Toxicol.
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Design, synthesis, biological ...
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Chloroquine binding reveals fl ...
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J. Biol. Chem.
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Antoine
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Characterization of cofactors, ...
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Int. J. Mass Spectrom.
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2012
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1
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2
1
1
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1
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1
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1
1
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4
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1
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1
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1
-
-
2
1
1
-
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-
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Michaelis
Dabigatran and dabigatran ethy ...
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2
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-
2
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1
3
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2
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1
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2
17
3
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2
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2
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-
2
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1
1
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724751
Dufour
Mechanism-based inhibition of ...
Homo sapiens
ChemBioChem
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1
1
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1
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1
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12
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1
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1
1
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725071
Reybier
Insights into the redox cycle ...
Homo sapiens
Free Radic. Res.
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1
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4
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1
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6
1
1
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1
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1
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1
1
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-
4
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1
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3
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1
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6
1
1
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-
1
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1
1
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711408
Nolan
Imidazoacridin-6-ones as novel ...
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Bioorg. Med. Chem. Lett.
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2010
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34
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34
34
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1
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711432
Nolan
In silico identification and b ...
Homo sapiens
Bioorg. Med. Chem. Lett.
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2010
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1
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1
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-
37
44
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1
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711470
Nolan
Triazoloacridin-6-ones as nove ...
Homo sapiens
Bioorg. Med. Chem.
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696-706
2010
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1
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1
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1
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1
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-
15
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1
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-
15
15
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1
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1
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-
1
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-
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711729
Ferry
Old and new inhibitors of quin ...
Homo sapiens
Chem. Biol. Interact.
186
103-109
2010
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6
10
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11
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1
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19
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1
1
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19
6
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10
1
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1
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11
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712829
Benoit
Loss of quinone reductase 2 fu ...
Rattus norvegicus
J. Neurosci.
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2010
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3
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1
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1
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1
1
1
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-
-
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2
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1
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1
-
3
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-
1
-
-
-
-
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-
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2
2
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-
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697007
Winger
The structure of the leukemia ...
Homo sapiens
BMC Struct. Biol.
9
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1
1
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1
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-
2
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1
-
1
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-
1
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1
-
1
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-
-
1
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-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
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698051
Gaikwad
Evidence for NQO2-mediated red ...
Homo sapiens
Free Radic. Biol. Med.
46
253-262
2009
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1
-
-
-
-
2
2
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1
-
1
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-
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3
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-
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-
1
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-
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1
-
1
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-
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2
-
2
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-
1
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-
3
-
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-
-
-
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699456
Maiti
Synthesis of casimiroin and op ...
Homo sapiens
J. Med. Chem.
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18
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1
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18
19
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1
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Wang
Association of NRH:quinone oxi ...
Homo sapiens
J. Gerontol. A Biol. Sci. Med. Sci.
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127-134
2008
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1
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1
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-
1
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695860
Boutin
Studies of the melatonin bindi ...
Homo sapiens
Arch. Biochem. Biophys.
477
12-19
2008
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1
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10
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1
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-
3
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1
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-
-
1
-
-
1
-
-
-
-
-
1
1
-
10
-
-
-
-
-
-
-
-
-
-
-
-
1
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3
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1
-
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-
1
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696093
Calamini
Kinetic, thermodynamic and X-r ...
Homo sapiens
Biochem. J.
413
81-91
2008
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1
1
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5
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1
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-
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-
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1
-
1
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-
1
-
-
-
2
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5
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-
1
-
1
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5
5
2
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1
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-
-
-
-
-
1
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-
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-
1
-
1
-
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-
1
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-
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-
-
-
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-
-
697413
Cai
Negative regulation of quinone ...
Oryctolagus cuniculus
Clin. Exp. Pharmacol. Physiol.
35
1419-1425
2008
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1
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-
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-
-
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1
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1
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1
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698793
Fu
Quinone reductase 2 is a catec ...
Rattus norvegicus
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1
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1
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686136
Jamieson
NAD(P)H:quinone oxidoreductase ...
Homo sapiens
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-
1
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-
1
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-
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-
-
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671921
Celli
NRH:quinone oxidoreductase 2 ( ...
Mus musculus
Biochem. Pharmacol.
72
366-376
2006
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5
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2
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1
2
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3
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1
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-
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5
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-
-
-
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673791
Wang
Nulear factor Nrf2 and antioxi ...
Homo sapiens
Free Radic. Biol. Med.
40
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1
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-
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1
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2
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1
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-
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1
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674664
Iskander
NQO1 and NQO2 regulation of hu ...
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2
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657888
Vella
NRH:quinone reductase 2: an en ...
Homo sapiens, Mus musculus
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2
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9
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5
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657889
Mailliet
Characterization of the melato ...
Homo sapiens
Biochem. Pharmacol.
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2005
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4
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1
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11
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16
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16
17
11
4
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1
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-
-
-
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658434
Boutin
Quinone reductase 2 substrate ...
Homo sapiens
Chem. Biol. Interact.
151
213-228
2005
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5
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1
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9
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1
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9
10
-
3
1
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671708
Fu
Crystal structure of quinone r ...
Homo sapiens
Biochem. Biophys. Res. Commun.
336
332-338
2005
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1
1
1
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1
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1
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1
-
-
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-
1
-
-
-
-
1
-
-
-
1
-
-
-
-
1
1
1
1
1
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
1
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-
-
-
-
-
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-
-
676176
Okada
No associations between Parkin ...
Homo sapiens
Neurosci. Lett.
375
178-180
2005
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-
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658817
Long
Mouse NRH:quinone oxidoreducta ...
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14
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659111
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Purification and properties of ...
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10
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