1.10.5.1: ribosyldihydronicotinamide dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about ribosyldihydronicotinamide dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.10.5.1

Reaction

1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide
+
a quinone
=
1-(beta-D-ribofuranosyl)nicotinamide
+
a quinol

Synonyms

bQR2, dihydronicotinamide riboside:quinone oxidoreductase, dihydronicotinamide riboside:quinone oxidoreductase 2, dihydronicotinamide riboside:quinone reductase 2, EC 1.10.99.2, melatonin-binding site MT3, MT3, MT3/NQO2, N-ribosyldihydronicotinamide dehydrogenase (quinone), N-ribosyldihydronicotinamide:quinone oxidoreductase 2, NQO2, NRH-oxidizing enzyme, NRH:QR2, NRH:quinone oxidoreductase, NRH:quinone oxidoreductase 2, NRH:quinone oxireductase 2, NRH:quinone reductase 2, QR2, quinone oxidoreductase 2, quinone reductase 2, quinone reductase type 2

ECTree

     1 Oxidoreductases
         1.10 Acting on diphenols and related substances as donors
             1.10.5 With a quinone or related compound as acceptor
                1.10.5.1 ribosyldihydronicotinamide dehydrogenase (quinone)

Reference

Reference on EC 1.10.5.1 - ribosyldihydronicotinamide dehydrogenase (quinone)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wu, K.; Knox, R.; Sun, X.Z.; Joseph, P.; Jaiswal, A.K.; Zhang, D.; Deng, P.S.K.; Chen, S.
Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase
Arch. Biochem. Biophys.
347
221-228
1997
Homo sapiens
Manually annotated by BRENDA team
Vella, F.; Ferry, G.; Delagrange, P.; Boutin, J.A.
NRH:quinone reductase 2: an enzyme of surprises and mysteries
Biochem. Pharmacol.
71
1-12
2005
Homo sapiens (P16083), Mus musculus
Manually annotated by BRENDA team
Mailliet, F.; Ferry, G.; Vella, F.; Berger, S.; Coge, F.; et.al.
Characterization of the melatoninergic MT3 binding site on the NRH:quinone oxidoreductase 2 enzyme
Biochem. Pharmacol.
71
74-88
2005
Homo sapiens
Manually annotated by BRENDA team
Buryanovskyy, L.; Fu, Y.; Boyd, M.; Ma, Y.; Hsieh, T.; Wu, J.M.; Zhang, Z.
Crystal structure of quinone reductase 2 in complex with resveratrol
Biochemistry
43
11417-11426
2004
Homo sapiens (P16083)
Manually annotated by BRENDA team
Long, D.J.2nd.; Jaiswal, A.K.
NRH:quinone oxidoreductase2 (NQO2)
Chem. Biol. Interact.
129
99-112
2000
Homo sapiens
Manually annotated by BRENDA team
Boutin, J.A.; Chatelein-Egger, F.; Vella, F.; Delagrange, P.; Ferry, G.
Quinone reductase 2 substrate specificity and inhibitgion pharmacology
Chem. Biol. Interact.
151
213-228
2005
Homo sapiens
Manually annotated by BRENDA team
Mailliet, F.; Ferry, G.; Vella, F.; Thiam, K.; Delagrange, P.; Boutin, J.A.
Organs from mice deleted for NRH:quinone oxidoreductase 2 are deprived of the melatonin binding site MT3
FEBS Lett.
578
116-120
2004
Mus musculus
Manually annotated by BRENDA team
Long, D.J.; Jaiswal, A.K.
Mouse NRH:quinone oxidoreductase (NQO2): cloning of cDNA and gene- and tissue-specific expression
Gene
252
107-117
2000
Mus musculus, Mus musculus (Q9JI75)
Manually annotated by BRENDA team
Liao, S.; Dulaney, J.T.; Williams-Ashman, H-.G.
Purification and properties of a flavoprotein catalyzing the oxidation of reduced ribosyl nicotinamide
J. Biol. Chem.
237
2981-2987
1962
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
Nosjean, O.; Ferro, M.; Coge, F.; Beauverger, P.; et al.
Identification of the melatonin-binding site MT3 as the quinone reductase 2
J. Biol. Chem.
275
31311-31317
2000
Homo sapiens, Mesocricetus auratus
Manually annotated by BRENDA team
Strassburg, A.; Strassburg, C.P.; Manns, M.P.; Tukey, R.H.
Differential gene expression of NAD(P)H:quinone oxidoreductase and NRH:quinone oxidoreductase in human hepatocellular and biliary tissue
Mol. Pharmacol.
61
320-325
2002
Homo sapiens, Homo sapiens (P16083)
Manually annotated by BRENDA team
Graves, P.R.; Kwiek, J.J.; Fadden, P.; et al.
Discovery of novel targets of quinoline drugs in the human purine binding proteome
Mol. Pharmacol.
62
1364-1372
2002
Homo sapiens
Manually annotated by BRENDA team
Zhao, Q.; Yang, X.L.; Holtzclaw, W.D.; Talalay, P.
Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)
Proc. Natl. Acad. Sci. USA
94
1669-1674
1997
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Fu, Y.; Buryanovskyy, L.; Zhang, Z.
Crystal structure of quinone reductase 2 in complex with cancer prodrug CB1954
Biochem. Biophys. Res. Commun.
336
332-338
2005
Homo sapiens
Manually annotated by BRENDA team
Celli, C.M.; Tran, N.; Knox, R.; Jaiswal, A.K.
NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs
Biochem. Pharmacol.
72
366-376
2006
Mus musculus, Mus musculus (Q9JI75)
Manually annotated by BRENDA team
Wang, W.; Jaiswal, A.K.
Nulear factor Nrf2 and antioxidant response element regulate NRH:quinone oxidoreductase 2 (NQO2) gene expression and antioxidant induction
Free Radic. Biol. Med.
40
1119-1130
2006
Homo sapiens
Manually annotated by BRENDA team
Iskander, K.; Li, J.; Han, S.; Zheng, B.; Jaiswal, A.K.
NQO1 and NQO2 regulation of humoral immunity and autoimmunity
J. Biol. Chem.
281
30917-30924
2006
Mus musculus
Manually annotated by BRENDA team
Okada, S.; Farin, F.M.; Stapleton, P.; Viernes, H.; Quigley, S.D.; Powers, K.M.; Smith-Weller, T.; Franklin, G.M.; Longstreth, W.T.; Swanson, P.D.; Checkoway, H.
No associations between Parkinsons disease and polymorphisms of the quinone oxidoreductase (NQO1, NQO2) genes
Neurosci. Lett.
375
178-180
2005
Homo sapiens
Manually annotated by BRENDA team
Jamieson, D.; Wilson, K.; Pridgeon, S.; Margetts, J.P.; Edmondson, R.J.; Leung, H.Y.; Knox, R.; Boddy, A.V.
NAD(P)H:quinone oxidoreductase 1 and NRH:quinone oxidoreductase 2 activity and expression in bladder and ovarian cancer and lower NRH:quinone oxidoreductase 2 activity associated with an NQO2 exon 3 single-nucleotide polymorphism
Clin. Cancer Res.
13
1584-1590
2007
Homo sapiens
Manually annotated by BRENDA team
Wang, W.; Le, W.; Pan, T.; Stringer, J.L.; Jaiswal, A.K.
Association of NRH:quinone oxidoreductase 2 gene promoter polymorphism with higher gene expression and increased susceptibility to Parkinsons disease
J. Gerontol. A Biol. Sci. Med. Sci.
63
127-134
2008
Homo sapiens
Manually annotated by BRENDA team
Boutin, J.A.; Saunier, C.; Guenin, S.P.; Berger, S.; Moulharat, N.; Gohier, A.; Delagrange, P.; Coge, F.; Ferry, G.
Studies of the melatonin binding site location onto quinone reductase 2 by directed mutagenesis
Arch. Biochem. Biophys.
477
12-19
2008
Homo sapiens
Manually annotated by BRENDA team
Calamini, B.; Santarsiero, B.D.; Boutin, J.A.; Mesecar, A.D.
Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2
Biochem. J.
413
81-91
2008
Homo sapiens (P16083)
Manually annotated by BRENDA team
Winger, J.A.; Hantschel, O.; Superti-Furga, G.; Kuriyan, J.
The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)
BMC Struct. Biol.
9
7
2009
Homo sapiens, Homo sapiens (P16083)
Manually annotated by BRENDA team
Cai, J.B.; Zhang, Z.H.; Xu, D.J.; Qian, Z.Y.; Wang, Z.R.; Huang, Y.Z.; Zou, J.G.; Cao, K.J.
Negative regulation of quinone reductase 2 by resveratrol in cultured vascular smooth muscle cells
Clin. Exp. Pharmacol. Physiol.
35
1419-1425
2008
Oryctolagus cuniculus
Manually annotated by BRENDA team
Gaikwad, N.W.; Yang, L.; Rogan, E.G.; Cavalieri, E.L.
Evidence for NQO2-mediated reduction of the carcinogenic estrogen ortho-quinones
Free Radic. Biol. Med.
46
253-262
2009
Homo sapiens
Manually annotated by BRENDA team
Fu, Y.; Buryanovskyy, L.; Zhang, Z.
Quinone reductase 2 is a catechol quinone reductase
J. Biol. Chem.
283
23829-23835
2008
Rattus norvegicus
Manually annotated by BRENDA team
Maiti, A.; Reddy, P.V.; Sturdy, M.; Marler, L.; Pegan, S.D.; Mesecar, A.D.; Pezzuto, J.M.; Cushman, M.
Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities
J. Med. Chem.
52
1873-1884
2009
Homo sapiens
Manually annotated by BRENDA team
Nolan, K.A.; Humphries, M.P.; Bryce, R.A.; Stratford, I.J.
Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2
Bioorg. Med. Chem. Lett.
20
2832-2836
2010
Homo sapiens
Manually annotated by BRENDA team
Nolan, K.A.; Caraher, M.C.; Humphries, M.P.; Bettley, H.A.; Bryce, R.A.; Stratford, I.J.
In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2)
Bioorg. Med. Chem. Lett.
20
7331-7336
2010
Homo sapiens
Manually annotated by BRENDA team
Nolan, K.A.; Humphries, M.P.; Barnes, J.; Doncaster, J.R.; Caraher, M.C.; Tirelli, N.; Bryce, R.A.; Whitehead, R.C.; Stratford, I.J.
Triazoloacridin-6-ones as novel inhibitors of the quinone oxidoreductases NQO1 and NQO2
Bioorg. Med. Chem.
18
696-706
2010
Homo sapiens (P16083)
Manually annotated by BRENDA team
Ferry, G.; Hecht, S.; Berger, S.; Moulharat, N.; Coge, F.; Guillaumet, G.; Leclerc, V.; Yous, S.; Delagrange, P.; Boutin, J.A.
Old and new inhibitors of quinone reductase 2
Chem. Biol. Interact.
186
103-109
2010
Homo sapiens
Manually annotated by BRENDA team
Benoit, C.E.; Bastianetto, S.; Brouillette, J.; Tse, Y.; Boutin, J.A.; Delagrange, P.; Wong, T.; Sarret, P.; Quirion, R.
Loss of quinone reductase 2 function selectively facilitates learning behaviors
J. Neurosci.
30
12690-12700
2010
Rattus norvegicus
Manually annotated by BRENDA team
John, S.E.St.; Jensen, K.C.; Kang, S.; Chen, Y.; Calamini, B.; Mesecar, A.D.; Lipton, M.A.
Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2
Bioorg. Med. Chem.
21
6022-6037
2013
Homo sapiens
Manually annotated by BRENDA team
Dufour, M.; Yan, C.; Siegel, D.; Colucci, M.A.; Jenner, M.; Oldham, N.J.; Gomez, J.; Reigan, P.; Li, Y.; De Matteis, C.I.; Ross, D.; Moody, C.J.
Mechanism-based inhibition of quinone reductase 2 (NQO2): selectivity for NQO2 over NQO1 and structural basis for flavoprotein inhibition
ChemBioChem
12
1203-1208
2011
Homo sapiens
Manually annotated by BRENDA team
Reybier, K.; Perio, P.; Ferry, G.; Bouajila, J.; Delagrange, P.; Boutin, J.A.; Nepveu, F.
Insights into the redox cycle of human quinone reductase 2
Free Radic. Res.
45
1184-1195
2011
Homo sapiens
Manually annotated by BRENDA team
Antoine, M.; Marcheteau, E.; Delagrange, P.; Ferry, G.; Boutin, J.
Characterization of cofactors, substrates and inhibitor binding to flavoenzyme quinone reductase 2 by automated supramolecular nano-electrospray ionization mass spectrometry
Int. J. Mass Spectrom.
312
87-96
2012
Homo sapiens
-
Manually annotated by BRENDA team
Leung, K.K.; Shilton, B.H.
Chloroquine binding reveals flavin redox switch function of quinone reductase 2
J. Biol. Chem.
288
11242-11251
2013
Homo sapiens, Homo sapiens (P16083)
Manually annotated by BRENDA team
Michaelis, S.; Marais, A.; Schrey, A.K.; Graebner, O.Y.; Schaudt, C.; Sefkow, M.; Kroll, F.; Dreger, M.; Glinski, M.; Koester, H.; Metternich, R.; Fischer, J.J.
Dabigatran and dabigatran ethyl ester: potent inhibitors of ribosyldihydronicotinamide dehydrogenase (NQO2)
J. Med. Chem.
55
3934-3944
2012
Homo sapiens
Manually annotated by BRENDA team
Riches, Z.; Liu, Y.; Berman, J.M.; Walia, G.; Collier, A.C.
The ontogeny and population variability of human hepatic dihydronicotinamide ribosidequinone oxidoreductase (NQO2)
J. Biochem. Mol. Toxicol.
31
0000
2017
Homo sapiens, Homo sapiens (P16083)
Manually annotated by BRENDA team