1.10.5.1: ribosyldihydronicotinamide dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about ribosyldihydronicotinamide dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.10.5.1

Reaction

1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide
+
a quinone
=
1-(beta-D-ribofuranosyl)nicotinamide
+
a quinol

Synonyms

bQR2, dihydronicotinamide riboside:quinone oxidoreductase, dihydronicotinamide riboside:quinone oxidoreductase 2, dihydronicotinamide riboside:quinone reductase 2, EC 1.10.99.2, melatonin-binding site MT3, MT3, MT3/NQO2, N-ribosyldihydronicotinamide dehydrogenase (quinone), N-ribosyldihydronicotinamide:quinone oxidoreductase 2, NQO2, NRH-oxidizing enzyme, NRH:QR2, NRH:quinone oxidoreductase, NRH:quinone oxidoreductase 2, NRH:quinone oxireductase 2, NRH:quinone reductase 2, QR2, quinone oxidoreductase 2, quinone reductase 2, quinone reductase type 2

ECTree

     1 Oxidoreductases
         1.10 Acting on diphenols and related substances as donors
             1.10.5 With a quinone or related compound as acceptor
                1.10.5.1 ribosyldihydronicotinamide dehydrogenase (quinone)

Source Tissue

Source Tissue on EC 1.10.5.1 - ribosyldihydronicotinamide dehydrogenase (quinone)

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
no significant difference in expression in normal and malignant biliary tissue. Activity of NQO2 is significatly lower than in hepatocellular tissue
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
the high NQO2 activity of intraperitoneal ovarian metastases relative to other tissues indicates a potential for tretazicar therapy in the treatment of this disease
Manually annotated by BRENDA team
-
minimal expression
Manually annotated by BRENDA team
-
suppression of vascular smooth muscle cell proliferation mediated by resveratrol correlates with vascular smooth muscle cell downregulation
Manually annotated by BRENDA team
additional information