Reference on EC 2.7.1.32 - choline kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ishidate, K.; Furusawa, K.; Nakazawa, Y.
Complete co-purification of choline kinase and ethanolamine kinase from rat kidney and immunological evidence for both kinase activities residing on the same enzyme protein(s) in rat tissues
Biochim. Biophys. Acta
836
119-124
1985
Rattus norvegicus
Upreti, R.K.; Sanwal, G.G.; Krishnan, P.S.
Likely individuality of the enzymes catalyzing the phosphorylation of choline and ethanolamine
Arch. Biochem. Biophys.
174
658-665
1976
Duttaphrynus melanostictus, Cavia porcellus, Gallus gallus, Columba livia, Hemidactylus sp., Heteropneustes fossilis, Mus musculus, Hoplobatrachus tigerinus, Rattus norvegicus
Brophy, P.J.; Choy, P.C.; Toone, J.R.; Vance, D.E.
Choline kinase and ethanolamine kinase are separate, soluble enzymes in rat liver
Eur. J. Biochem.
78
491-495
1977
Rattus norvegicus
Weinhold, P.A.; Rethy, V.B.
The separation, purification, and characterization of ethanolamine kinase and choline kinase from rat liver
Biochemistry
13
5135-5141
1974
Rattus norvegicus
Spanner, S.; Ansell, G.B.
Choline kinase and ethanolamine kinase activity in the cytoplasm of nerve endings from rat forebrain
Biochem. Soc. Trans.
5
164-165
1977
Rattus norvegicus
Ramabrahmam, P.; Subrahmanyam, D.
Ethanolamine kinase from Culex pipiens fatigans
Arch. Biochem. Biophys.
207
55-62
1981
Culex quinquefasciatus
Wittenberg, J.; Kornberg, A.
Choline phosphokinase
J. Biol. Chem.
202
431-444
1953
Saccharomyces cerevisiae
Uchida, T.; Yamashita, S.
Molecular cloning, characterization, and expression in Escherichia coli of a cDNA encoding mammalian choline kinase
J. Biol. Chem.
267
10156-10162
1992
Rattus norvegicus
Hosaka, K.; Tanaka, S.; Nikawa, J.; Yamashita, S.
Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation
FEBS Lett.
304
229-232
1992
Homo sapiens
Infante, J.P.; Kinsella, J.E.
Phospholipid synthesis in mammary tissue. Choline and ethanolamine kinases: kinetic evidence for two discrete active sites
Lipids
11
727-735
1976
Bos taurus
Shelley, R.M.; Hodgson, E.
Substrate specificity and inhibition of choline and ethanolamine kinases from the fat body of Phormia rigina larvae
Insect Biochem.
1
149-156
1971
Phormia regina
-
Hartmann, E.; Schleicher, W.
Isolation and characterization of a choline kinase from Phaseolus vulgaris L. seedlings
Z. Pflanzenphysiol.
83
69-80
1977
Phaseolus vulgaris
-
Haubrich, D.R.
Partial purification and properties of choline kinase (EC 2. 7. 1. 32) from rabbit brain: measurement of acetylcholine
J. Neurochem.
21
315-328
1973
Oryctolagus cuniculus
Ramabrahamam, P.; Subrahmanaym, D.
Choline kinase of Culex pipiens fatigans
Insect Biochem.
9
315-321
1979
Culex quinquefasciatus
-
Uchida, T.; Yamashita, S.
Purification and properties of choline kinase from rat brain
Biochim. Biophys. Acta
1043
281-288
1990
Rattus norvegicus
Ishidate, K.; Nakagomi, K.; Nakazawa, Y.
Complete purification of choline kinase from rat kidney and preparation of rabbit antibody against rat kidney choline kinase
J. Biol. Chem.
259
14706-14710
1984
Rattus norvegicus
Brostrom, M.A.; Browning, E.T.
Choline kinase from brewers yeast. Partial purification, properties, and kinetic mechanism
J. Biol. Chem.
248
2364-2371
1973
Saccharomyces cerevisiae
Setty, P.N.; Krishnan, P.S.
Choline kinase in Cuscuta reflexa
Biochem. J.
126
313-324
1972
Cuscuta reflexa
Clary, G.L.; Tsai, C.F.; Guynn, R.W.
Substrate specificity of choline kinase
Arch. Biochem. Biophys.
254
214-221
1987
Saccharomyces cerevisiae
Kinney, A.J.; Moore, T.S.
Phosphatidylcholine synthesis in castor bean endosperm: characteristics and reversibility of the choline kinase reaction
Arch. Biochem. Biophys.
260
102-108
1988
Ricinus communis
Hock, K.; Hartmann, E.
Localization of phosphatidylcholine synthesizing enzymes in etiolated bean seedlings (Phaseolus vulgaris L.)
Plant Sci. Lett.
21
389-396
1981
Phaseolus vulgaris
-
Fukuyama, H.; Yamashita, S.
Activation of rat liver choline kinase by polyamines
FEBS Lett.
71
33-36
1976
Rattus norvegicus
-
Kariya, Y.; Kimura, A.; Aisaka, K.; Tochikura, T.
Isolation and purification of choline kinase from Hansenula jadinii
J. Ferment. Technol.
58
489-492
1980
Cyberlindnera jadinii
-
Porter, T.J.; Kent, C.
Purification and characterization of choline/ethanolamine kinase from rat liver
J. Biol. Chem.
265
414-422
1990
Rattus norvegicus
Ulane, R.E.; Stephenson, L.L.; Farrell, P.M.
Evidence for the existence of a single enzyme catalyzing the phosphorylation of choline and ethanolamine in primate lung
Biochim. Biophys. Acta
531
295-300
1978
Chlorocebus aethiops
Porter, T.J.; Kent, C.
Choline/ethanolamine kinase from rat liver
Methods Enzymol.
209
134-146
1992
Rattus norvegicus
Uchida, T.; Yamashita, S.
Choline/ethanolamine kinase from rat brain
Methods Enzymol.
209
147-153
1992
Rattus norvegicus
Ishidate, K.; Nakazawa, Y.
Choline/ethanolamine kinase from rat kidney
Methods Enzymol.
209
121-134
1992
Rattus norvegicus
Hernandez-Alcoceba, R.; Fernandez, F.; Lacal, J.C.
In vivo antitumor activity of choline kinase inhibitors: a novel target for anticancer drug discovery
Cancer Res.
59
3112-3118
1999
Homo sapiens
Yamashita, S.; Hosaka, K.
Choline kinase from yeast
Biochim. Biophys. Acta
1348
63-69
1997
Saccharomyces cerevisiae
Gee, P.; Kent, C.
Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization
Biochim. Biophys. Acta
1648
33-42
2003
Caenorhabditis elegans
Yu, Y.; Sreenivas, A.; Ostrander, D.B.; Carman, G.M.
Phosphorylation of Saccharomyces cerevisiae Choline Kinase on Ser30 and Ser85 by Protein Kinase A Regulates Phosphatidylcholine Synthesis by the CDP-choline Pathway
J. Biol. Chem.
277
34978-34986
2002
Saccharomyces cerevisiae
Kim, K.H.; Voelker, D.R.; Flocco, M.T.; Carman, G.M.
Expression, purification, and characterization of choline kinase, product of the CKI gene from Saccharomyces cerevisiae
J. Biol. Chem.
273
6844-6852
1998
Saccharomyces cerevisiae
Aoyama, C.; Ohtani, A.; Ishidate, K.
Expression and characterization of the active molecular forms of choline/ethanolamine kinase-alpha and -beta in mouse tissues, including carbon tetrachloride-induced liver
Biochem. J.
363
777-784
2002
Mus musculus
Ishidate, K.
Choline/ethanolamine kinase from mammalian tissues
Biochim. Biophys. Acta
1348
70-78
1997
Homo sapiens, Rattus norvegicus
Al-Malki, A.; Morby, A.; Harwood, J.L.
Pea choline kinase: purification, properties and isolation of a cDNA
Biochem. Soc. Trans.
28
721-723
2000
Pisum sativum
Liu, Y.; Ekambaram, M.C.; Blum, P.S.; Stimbert, C.D.; Jernigan, H.M., Jr.
Galactosemic cataractogenesis disrupts intracellular interactions and changes the substrate specificity of choline/ethanolamine kinase
Exp. Eye Res.
67
193-202
1998
Rattus norvegicus
Menten, J.F.M.; Pesti, G.M.
The determination of the choline content of feed ingredients using choline kinase
J. Sci. Food Agric.
78
395-398
1998
Brassica sp., Glycine max, Zea mays
Aoyama, C.; Yamazaki, N.; Terada, H.; Ishidate, K.
Structure and characterization of the genes for murine choline/ethanolamine kinase isozymes alpha and beta
J. Lipid Res.
41
452-464
2000
Mus musculus (O54804), Mus musculus
Peisach, D.; Gee, P.; Kent, C.; Xu, Z.
The crystal structure of choline kinase reveals a eukaryotic protein kinase fold
Structure
11
703-713
2003
Caenorhabditis elegans
Cao, Z.M.; Kanfer, J.N.
Partial purification of two forms of choline kinase and separation of choline kinase from sphingosine kinase of rat brain
Neurochem. Res.
20
643-649
1995
Rattus norvegicus
Tasseva, G.; Richard, L.; Zachowski, A.
Regulation of phosphatidylcholine biosynthesis under salt stress involves choline kinases in Arabidopsis thaliana
FEBS Lett.
566
115-120
2004
Arabidopsis thaliana
Yuan, C.; Kent, C.
Identification of critical residues of ATP kinase A2 from Caenorhabditis elegans
J. Biol. Chem.
279
17801-17809
2004
Caenorhabditis elegans
Rodriguez-Gonzalez, A.; Ramirez de Molina, A.; Benitez-Rajal, J.; Lacal, J.C.
Phospholipase D and choline kinase: their role in cancer development and their potential as drug targets
Prog. Cell Cycle Res.
5
191-201
2003
Mus musculus (Q54AG5), Homo sapiens (Q9Y259)
Aoyama, C.; Liao, H.; Ishidate, K.
Structure and function of choline kinase isoforms in mammalian cells
Prog. Lipid Res.
43
266-281
2004
Saccharomyces cerevisiae, Caenorhabditis elegans, Homo sapiens, Mus musculus, Rattus norvegicus
Al-Saeedi, F.; Smith, T.; Welch, A.
[Methyl-3H]-choline incorporation into MCF-7 cells: correlation with proliferation, choline kinase and phospholipase D assay
Anticancer Res.
27
901-906
2007
Homo sapiens
Choubey, V.; Maity, P.; Guha, M.; Kumar, S.; Srivastava, K.; Puri, S.K.; Bandyopadhyay, U.
Inhibition of Plasmodium falciparum choline kinase by hexadecyltrimethylammonium bromide: a possible antimalarial mechanism
Antimicrob. Agents Chemother.
51
696-706
2007
Plasmodium falciparum
Choubey, V.; Guha, M.; Maity, P.; Kumar, S.; Raghunandan, R.; Maulik, P.R.; Mitra, K.; Halder, U.C.; Bandyopadhyay, U.
Molecular characterization and localization of Plasmodium falciparum choline kinase
Biochim. Biophys. Acta
1760
1027-1038
2006
Plasmodium falciparum
Liao, H.; Aoyama, C.; Ishidate, K.; Teraoka, H.
Deletion and alanine mutation analyses for the formation of active homo- or hetero-dimer complexes of mouse choline kinase-alpha and -beta
Biochim. Biophys. Acta
1761
111-120
2006
Mus musculus
Glunde, K.; Raman, V.; Mori, N.; Bhujwalla, Z.M.
RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation
Cancer Res.
65
11034-11043
2005
Homo sapiens
Milanese, L.; Espinosa, A.; Campos, J.M.; Gallo, M.A.; Entrena, A.
Insight into the inhibition of human choline kinase: homology modeling and molecular dynamics simulations
ChemMedChem
1
1216-1228
2006
Caenorhabditis elegans, Homo sapiens
Janardhan, S.; Srivani, P.; Sastry, G.N.
Choline kinase: an important target for cancer
Curr. Med. Chem.
13
1169-1186
2006
Saccharomyces cerevisiae, Caenorhabditis elegans, Homo sapiens, Mus musculus, Rattus norvegicus, Schizosaccharomyces pombe
Campos, J.M.; Sanchez-Martin, R.M.; Conejo-Garcia, A.; Entrena, A.; Gallo, M.A.; Espinosa, A.
(Q)SAR studies to design new human choline kinase inhibitors as antiproliferative drugs
Curr. Med. Chem.
13
1231-1248
2006
Homo sapiens
Conejo-Garcia, A.; Entrena, A.; Campos, J.M.; Sanchez-Martin, R.M.; Gallo, M.A.; Espinosa, A.
Towards a model for the inhibition of choline kinase by a new type of inhibitor
Eur. J. Med. Chem.
40
315-319
2005
Homo sapiens
Rodriguez-Gonzalez, A.; Ramirez de Molina, A.; Banez-Coronel, M.; Megias, D.; Lacal, J.C.
Inhibition of choline kinase renders a highly selective cytotoxic effect in tumour cells through a mitochondrial independent mechanism
Int. J. Oncol.
26
999-1008
2005
Homo sapiens
Choi, M.G.; Kurnov, V.; Kersting, M.C.; Sreenivas, A.; Carman, G.M.
Phosphorylation of the yeast choline kinase by protein kinase C. Identification of Ser25 and Ser30 as major sites of phosphorylation
J. Biol. Chem.
280
26105-26112
2005
Saccharomyces cerevisiae, Saccharomyces cerevisiae KS106
Malito, E.; Sekulic, N.; Too, W.C.; Konrad, M.; Lavie, A.
Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine
J. Mol. Biol.
364
136-151
2006
Homo sapiens (P35790), Homo sapiens
Gibellini, F.; Hunter, W.N.; Smith, T.K.
Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases
Biochem. J.
415
135-144
2008
Trypanosoma brucei
Aoyama, C.; Ishidate, K.; Sugimoto, H.; Vance, D.E.
Induction of choline kinase alpha by carbon tetrachloride (CCl4) occurs via increased binding of c-jun to an AP-1 element
Biochim. Biophys. Acta
1771
1148-1155
2007
Mus musculus, Mus musculus (O54804)
Mori, N.; Glunde, K.; Takagi, T.; Raman, V.; Bhujwalla, Z.M.
Choline kinase down-regulation increases the effect of 5-fluorouracil in breast cancer cells
Cancer Res.
67
11284-11290
2007
Homo sapiens
Glunde, K.; Shah, T.; Winnard, P.T.; Raman, V.; Takagi, T.; Vesuna, F.; Artemov, D.; Bhujwalla, Z.M.
Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model
Cancer Res.
68
172-180
2008
Homo sapiens
Ramirez de Molina, A.; Gallego-Ortega, D.; Sarmentero-Estrada, J.; Lagares, D.; Gomez Del Pulgar, T.; Bandres, E.; Garcia-Foncillas, J.; Lacal, J.C.
Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy
Int. J. Biochem. Cell Biol.
40
1753-1763
2008
Homo sapiens
Soto, A.; Carman, G.M.
Regulation of the Saccharomyces cerevisiae CKI1-encoded choline kinase by zinc depletion
J. Biol. Chem.
283
10079-10088
2008
Saccharomyces cerevisiae
Aoyama, C.; Young, S.G.; Vance, D.E.
Early embryonic lethality caused by disruption of the gene for choline kinase alpha, the first enzyme in phosphatidylcholine biosynthesis
J. Biol. Chem.
283
1456-1462
2008
Mus musculus
Ramirez de Molina, A.; Sarmentero-Estrada, J.; Belda-Iniesta, C.; Taron, M.; Ramirez de Molina, V.; Cejas, P.; Skrzypski, M.; Gallego-Ortega, D.; de Castro, J.; Casado, E.; Garcia-Cabezas, M.A.; Sanchez, J.J.; Nistal, M.; Rosell, R.; Gonzalez-Baron, M.; Lacal, J.C.
Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study
Lancet Oncol.
8
889-897
2007
Homo sapiens
Alberge, B.; Gannoun-Zaki, L.; Bascunana, C.; Tran van Ba, C.; Vial, H.; Cerdan, R.
Comparison of the cellular and biochemical properties of Plasmodium falciparum choline and ethanolamine kinases
Biochem. J.
425
149-158
2010
Plasmodium falciparum 3D7 (Q8IM71)
Srivani, P.; Sastry, G.N.
Potential choline kinase inhibitors: a molecular modeling study of bis-quinolinium compounds
J. Mol. Graph. Model.
27
676-688
2009
Homo sapiens (P35790)
Elswaifi, S.F.; St Michael, F.; Sreenivas, A.; Cox, A.; Carman, G.M.; Inzana, T.J.
Molecular characterization of phosphorylcholine expression on the lipooligosaccharide of Histophilus somni
Microb. Pathog.
47
223-230
2009
Histophilus somni (B0URY8), Histophilus somni
Ross, J.; Najjar, A.M.; Sankaranarayanapillai, M.; Tong, W.P.; Kaluarachchi, K.; Ronen, S.M.
Fatty acid synthase inhibition results in a magnetic resonance-detectable drop in phosphocholine
Mol. Cancer Ther.
7
2556-2565
2008
Homo sapiens
Chua, B.T.; Gallego-Ortega, D.; Ramirez de Molina, A.; Ullrich, A.; Lacal, J.C.; Downward, J.
Regulation of Akt(ser473)phosphorylation by Choline kinase in breast carcinoma cells
Mol. Cancer
8
131
2009
Homo sapiens
Nimmagadda, S.; Glunde, K.; Pomper, M.G.; Bhujwalla, Z.M.
Pharmacodynamic markers for choline kinase down-regulation in breast cancer cells
Neoplasia
11
477-484
2009
Homo sapiens
Yalcin, A.; Clem, B.; Makoni, S.; Clem, A.; Nelson, K.; Thornburg, J.; Siow, D.; Lane, A.N.; Brock, S.E.; Goswami, U.; Eaton, J.W.; Telang, S.; Chesney, J.
Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling
Oncogene
29
139-149
2009
Homo sapiens
Gallego-Ortega, D.; Ramirez de Molina, A.; Ramos, M.A.; Valdes-Mora, F.; Barderas, M.G.; Sarmentero-Estrada, J.; Lacal, J.C.
Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment
PLoS ONE
4
e7819
2009
Homo sapiens (P35790), Homo sapiens (Q9Y259), Homo sapiens
Sahun-Roncero, M.; Rubio-Ruiz, B.; Saladino, G.; Conejo-Garcia, A.; Espinosa, A.; Velazquez-Campoy, A.; Gervasio, F.L.; Entrena, A.; Hurtado-Guerrero, R.
The mechanism of allosteric coupling in choline kinase alpha1 revealed by the action of a rationally designed inhibitor
Angew. Chem. Int. Ed. Engl.
52
4582-4586
2013
Helicobacter pylori
Wu, G.; Sher, R.; Cox, G.; Vance, D.
Differential expression of choline kinase isoforms in skeletal muscle explains the phenotypic variability in the rostrocaudal muscular dystrophy mouse
Biochim. Biophys. Acta
1801
446-454
2010
Mus musculus
Hudson, C.S.; Knegtel, R.M.; Brown, K.; Charlton, P.A.; Pollard, J.R.
Kinetic and mechanistic characterisation of choline kinase-alpha
Biochim. Biophys. Acta
1834
1107-1116
2013
Homo sapiens (P35790), Homo sapiens
Rubio-Ruiz, B.; Conejo-Garcia, A.; Rios-Marco, P.; Carrasco-Jimenez, M.P.; Segovia, J.; Marco, C.; Gallo, M.A.; Espinosa, A.; Entrena, A.
Design, synthesis, theoretical calculations and biological evaluation of new non-symmetrical choline kinase inhibitors
Eur. J. Med. Chem.
50
154-162
2012
Homo sapiens (P35790)
Gruber, J.; See Too, W.C.; Wong, M.T.; Lavie, A.; McSorley, T.; Konrad, M.
Balance of human choline kinase isoforms is critical for cell cycle regulation: implications for the development of choline kinase-targeted cancer therapy
FEBS J.
279
1915-1928
2012
Homo sapiens
Hong, B.S.; Allali-Hassani, A.; Tempel, W.; Finerty, P.J.; Mackenzie, F.; Dimov, S.; Vedadi, M.; Park, H.W.
Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity
J. Biol. Chem.
285
16330-16340
2010
Homo sapiens (P35790), Homo sapiens (Q9Y259), Homo sapiens
Sampels, V.; Hartmann, A.; Dietrich, I.; Coppens, I.; Sheiner, L.; Striepen, B.; Herrmann, A.; Lucius, R.; Gupta, N.
Conditional mutagenesis of a novel choline kinase demonstrates plasticity of phosphatidylcholine biogenesis and gene expression in Toxoplasma gondii
J. Biol. Chem.
287
16289-16299
2012
Toxoplasma gondii
Bansal, A.; Harris, R.A.; DeGrado, T.R.
Choline phosphorylation and regulation of transcription of choline kinase alpha in hypoxia
J. Lipid Res.
53
149-157
2012
Homo sapiens
Miyake, T.; Parsons, S.J.
Functional interactions between choline kinase alpha, epidermal growth factor receptor and c-Src in breast cancer cell proliferation
Oncogene
31
1431-1441
2012
Homo sapiens (P35790)
Li, Z.; Wu, G.; van der Veen, J.N.; Hermansson, M.; Vance, D.E.
Phosphatidylcholine metabolism and choline kinase in human osteoblasts
Biochim. Biophys. Acta
1841
859-867
2014
Homo sapiens (P35790), Homo sapiens
Schiaffino-Ortega, S.; Lopez-Cara, L.C.; Rios-Marco, P.; Carrasco-Jimenez, M.P.; Gallo, M.A.; Espinosa, A.; Marco, C.; Entrena, A.
New non-symmetrical choline kinase inhibitors
Bioorg. Med. Chem.
21
7146-7154
2013
Homo sapiens (P35790)
Rubio-Ruiz, B.; Figuerola-Conchas, A.; Ramos-Torrecillas, J.; Capitan-Canadas, F.; Rios-Marco, P.; Carrasco, M.P.; Gallo, M.A.; Espinosa, A.; Marco, C.; Ruiz, C.; Entrena, A.; Hurtado-Guerrero, R.; Conejo-Garcia, A.
Discovery of a new binding site on human choline kinase alpha1: design, synthesis, crystallographic studies, and biological evaluation of asymmetrical bispyridinium derivatives
J. Med. Chem.
57
507-515
2014
Homo sapiens (P35790), Homo sapiens
Zech, S.G.; Kohlmann, A.; Zhou, T.; Li, F.; Squillace, R.M.; Parillon, L.E.; Greenfield, M.T.; Miller, D.P.; Qi, J.; Thomas, R.M.; Wang, Y.; Xu, Y.; Miret, J.J.; Shakespeare, W.C.; Zhu, X.; Dalgarno, D.C.
Novel small molecule inhibitors of choline kinase identified by fragment-based drug discovery
J. Med. Chem.
59
671-686
2016
Homo sapiens (P35790), Homo sapiens
Trousil, S.; Carroll, L.; Kalusa, A.; Aberg, O.; Kaliszczak, M.; Aboagye, E.O.
Design of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors
MedChemComm
2013
693-696
2013
Homo sapiens
Mori, N.; Gadiya, M.; Wildes, F.; Krishnamachary, B.; Glunde, K.; Bhujwalla, Z.M.
Characterization of choline kinase in human endothelial cells
NMR Biomed.
26
1501-1507
2013
Homo sapiens (P35790), Homo sapiens
Wang, L.; Jiang, Y.L.; Zhang, J.R.; Zhou, C.Z.; Chen, Y.
Structural and enzymatic characterization of the choline kinase LicA from Streptococcus pneumoniae
PLoS ONE
10
e0120467
2015
Streptococcus pneumoniae (Q8DPI4), Streptococcus pneumoniae
Chang, C.C.; Few, L.L.; Konrad, M.; See Too, W.C.
Phosphorylation of human choline kinase beta by protein kinase A: its impact on activity and inhibition
PLoS ONE
11
e0154702
2016
Homo sapiens (Q9Y259), Homo sapiens
Schiaffino-Ortega, S.; Baglioni, E.; Mariotto, E.; Bortolozzi, R.; Serran-Aguilera, L.; Rios-Marco, P.; Carrasco-Jimenez, M.P.; Gallo, M.A.; Hurtado-Guerrero, R.; Marco, C.; Basso, G.; Viola, G.; Entrena, A.; Lopez-Cara, L.C.
Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human choline kinase alpha1 (ChoKalpha1)
Sci. Rep.
6
23793
2016
Homo sapiens (P35790), Homo sapiens
Kall, S.L.; Delikatny, E.J.; Lavie, A.
Identification of a unique inhibitor-binding site on choline kinase alpha
Biochemistry
57
1316-1325
2018
Homo sapiens (P35790)
Torretta, A.; Lopez-Cara, L.; Parisini, E.
Crystal structure of the apo and the adp-bound form of choline kinase from Plasmodium falciparum
Crystals
10
1-13
2020
Plasmodium falciparum (Q8IM71)
-
Zimmerman, T.; Lacal, J.C.; Ibrahim, S.A.
Choline kinase emerges as a promising drug target in Gram-positive bacteria
Front. Microbiol.
6
2146
2019
Haemophilus influenzae (P14181), Haemophilus influenzae, Streptococcus pneumoniae (Q8DPI4), Streptococcus pneumoniae, Haemophilus influenzae R6 (P14181), Haemophilus influenzae ATCC BAA-255 (P14181), Streptococcus pneumoniae ATCC BAA-255 (Q8DPI4)
Zech, S.; Kohlmann, A.; Zhou, T.; Li, F.; Squillace, R.; Parillon, L.; Greenfield, M.; Miller, D.; Qi, J.; Thomas, R.; Wang, Y.; Xu, Y.; Miret, J.; Shakespeare, W.; Zhu, X.; Dalgarno, D.
Novel small molecule inhibitors of choline kinase identified by fragment-based drug discovery
J. Med. Chem.
59
671-686
2016
Homo sapiens (O54804), Homo sapiens
Rubio-Ruiz, B.; Rixados-Marco, P.; Carrasco-Jimenez, M.; Espinosa, A.; Hurtado-Guerrero, R.; Marco, C.; Conejo-Garcixada, A.; Entrena, A.
Choline kinase inhibition and docking studies of a series of 6-(benzylthio)-9H-purin-9-yl-pyridinium derivatives
Med. Chem. Res.
26
2809-2815
2017
Homo sapiens (O54804)
-
Lin, Y.C.; Kanehara, K.; Nakamura, Y.
Arabidopsis CHOLINE/ETHANOLAMINE KINASE 1 (CEK1) is a primary choline kinase localized at the endoplasmic reticulum (ER) and involved in ER stress tolerance
New Phytol.
223
1904-1917
2019
Arabidopsis thaliana (Q8L518), Arabidopsis thaliana (Q9M9H6), Arabidopsis thaliana (Q9SZ92), Arabidopsis thaliana Col-0 (Q8L518), Arabidopsis thaliana Col-0 (Q9M9H6), Arabidopsis thaliana Col-0 (Q9SZ92)
Zimmerman, T.; Chasten, V.; Lacal, J.C.; Ibrahim, S.A.
Identification and validation of novel and more effective choline kinase inhibitors against Streptococcus pneumoniae
Sci. Rep.
10
15418
2020
Streptococcus pneumoniae (Q8DPI4), Streptococcus pneumoniae, Streptococcus pneumoniae ATCC BAA-255 (Q8DPI4)
Kall, S.L.; Whitlatch, K.; Smithgall, T.E.; Lavie, A.
Molecular basis for the interaction between human choline kinase alpha and the SH3 domain of the c-Src tyrosine kinase
Sci. Rep.
9
17121
2019
Homo sapiens (P35790), Homo sapiens
Pulido, S.A.; Nguyen, V.H.; Alzate, J.F.; Cedeno, D.L.; Makurath, M.A.; Rios-Vasquez, A.; Duque-Benitez, S.M.; Jones, M.A.; Robledo, S.M.; Friesen, J.A.
Insights into the phosphatidylcholine and phosphatidylethanolamine biosynthetic pathways in Leishmania parasites and characterization of a choline kinase from Leishmania infantum
Comp. Biochem. Physiol. B
213
45-54
2017
Leishmania infantum (A4IB50), Leishmania infantum, Leishmania infantum JPCM5 (A4IB50)
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