Any feedback?
Literature summary for 2.7.1.32 extracted from
- Induction of choline kinase alpha by carbon tetrachloride (CCl4) occurs via increased binding of c-jun to an AP-1 element (2007), Biochim. Biophys. Acta, 1771, 1148-1155.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| carbon tetrachloride | CCl4, major increase in the transcript for choline kinase alpha expression in livers from mice 3 h and 6 h after administration of carbon tetrachloride. CK-beta is unaffected by the carbon tetrachloride treatment. Choline kinase activity is induced in murine livers by carbon tetrachloride as a result of an increase in the expression of the mRNA for CK-alpha and Ck-alpha protein. | Mus musculus |  |
| carbon tetrachloride | CK activity is induced by carbon tetrachloride as a result of an increase in the expression of the mRNA for CK alpha and CK alpha protein. The transcriptional activity of CK alpha was markedly increased 3 h and 6 h after treatment with carbon tetrachloride. Carbon tetrachloride promotes the expression of the transcription factor activator protein 1 (AP-1) that increases CK expression and activity. | Mus musculus | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| a series of luciferase vectors that contained the CKalpha promoter and ranged from +57 to -3840 bp is constructed. The vectors are cotransfected into hepa-1 cells with the renilla luciferase expression vector as a control | Mus musculus |
| To identify the region of the CK apha promoter that is important to regulate its transcription, a series of luciferase vectors that contained the CK alpha promoter and ranged from +57 to -3840 bp are constructed. The vectors are cotransfected into Hepa-1 cells with the renilla luciferase expression vector as a control | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Mus musculus | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| choline + ATP | Mus musculus | first enzyme in the CDP-choline (Kennedy) pathway for the biosynthesis of phosphatidylcholine | phosphocholine + ADP | choline kinase supply phosphocholine for the biosynthesis of phosphatidylcholine that is essential for growth and cell division | ? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Mus musculus | O54804 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Hepa-1 cell | - |
Mus musculus | - |
| hepatoma cell line | Hepa-1 | Mus musculus | - |
| liver | from male mice C57B16 (12 weeks old) | Mus musculus | - |
| liver | Male C57Bl6 mice (12 weeks old) are injected intraperitoneally with carbon tetrachloride dissolved in olive oil at the dosage of 3 ml/kg. Mice are killed at indicated times and the livers quickly removed. | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| choline + ATP | first enzyme in the CDP-choline (Kennedy) pathway for the biosynthesis of phosphatidylcholine | Mus musculus | phosphocholine + ADP | choline kinase supply phosphocholine for the biosynthesis of phosphatidylcholine that is essential for growth and cell division | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| choline kinase | - |
Mus musculus |
| choline kinase alpha | - |
Mus musculus |
| CK | - |
Mus musculus |
| CK-alpha1 | - |
Mus musculus |
| CK-alpha2 | - |
Mus musculus |
| CK-beta | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
