Literature summary for 2.7.1.32 extracted from

Wu, G.; Sher, R.; Cox, G.; Vance, D.
Differential expression of choline kinase isoforms in skeletal muscle explains the phenotypic variability in the rostrocaudal muscular dystrophy mouse (2010), Biochim. Biophys. Acta, 1801, 446-454.

Search for more literature for 2.7.1.32

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
skeletal muscle	choline kinase beta is the major isoform in hindlimb muscle and contributes more to choline kinase activity, while choline kinase alpha is predominant in forelimb muscle and contributes more to choline kinase activity	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + choline	-	Mus musculus	ADP + phosphocholine	-	?

Synonyms

Synonyms	Comment	Organism
choline kinase alpha	isoform	Mus musculus
choline kinase beta	isoform	Mus musculus
CKalpha	isoform	Mus musculus
CKbeta	isoform	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	choline kinase activity in forelimb and hindlimb muscle decreases with increasing age from 1 to 8 weeks	down

General Information

General Information	Comment	Organism
malfunction	deletion of choline kinase gene Chkb results in neonatal forelimb bone deformity and hindlimb muscular dystrophy. The virtual elimination of all choline kinase activity in hindlimb muscle of Chkb-/- mice is not compensated by isoform CKalpha activity and muscular dystrophy develops. In contrast, in forelimb muscles of these mice, the 50% of total choline kinase activity remaining (due to isoform CKalpha), and the increased activity of CTP:phosphocholine cytidylyltransferase, ensure that the amount of phosphocholine is not reduced so that only minimal signs of muscular dystrophy develop as the mice age	Mus musculus

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Release 2023.1 (January 2023)