2.7.7.14: ethanolamine-phosphate cytidylyltransferase
This is an abbreviated version!
For detailed information about ethanolamine-phosphate cytidylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.14
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2.7.7.14
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phosphatidylethanolamine
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phospholipid
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cdp-ethanolamine
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diacylglycerols
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kennedy
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cdp-choline
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ctp:phosphocholine
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phosphocholine
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3hethanolamine
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ptdetn
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ethanolaminephosphotransferase
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14cethanolamine
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drug development
- 2.7.7.14
- phosphatidylethanolamine
- phospholipid
- cdp-ethanolamine
- diacylglycerols
-
kennedy
- cdp-choline
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ctp:phosphocholine
- phosphocholine
-
3hethanolamine
-
ptdetn
- ethanolaminephosphotransferase
-
14cethanolamine
- drug development
Reaction
Synonyms
CTP-phosphoethanolamine cytidylyltransferase, CTP:ethanolaminephosphate cytidylyltransferase, CTP:phosphoethanolamine CT, CTP:phosphoethanolamine cytidylyltransferase, CTP:phosphoethanolamine cytidylyltransferase gene, cytidylyltransferase, ethanolamine phosphate, ECT, ET, ethanolamine phosphate cytidylyltransferase, ethanolamine-phosphate cytidylyltransferase, Pcyt2, Pcyt2alpha, Pcyt2beta, PECT1, phosphoethanolamine cytidyltransferase, phosphoethanolamine cytidylyltransferase, phosphorylethanolamine transferase, Tb11.01.5730
ECTree
2.7.7.14 ethanolamine-phosphate cytidylyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.7.7.14 - ethanolamine-phosphate cytidylyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CTP + 2-aminoethylarsonic acid
diphosphate + cytidine-O-PO2-O-AsO2-CH2-CH2-NH3+
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-
spontaneous hydrolysis to CMP and-O-AsO2--CH2-CH2-NH3+
?
CTP + phosphodimethylethanolamine
diphosphate + CDP-dimethylethanolamine
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-
-
-
?
CTP + phosphomonomethylethanolamine
diphosphate + CDP-methylethanolamine
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-
-
-
?
CTP + ethanolamine phosphate
CDP-ethanolamine + diphosphate
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-
-
-
?
CTP + ethanolamine phosphate
CDP-ethanolamine + diphosphate
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-
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?
CTP + ethanolamine phosphate
diphosphate + CDP-ethanolamine
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rate limiting enzyme in phosphatidylethanolamine biosynthesis. Defects in CTP:phosphorylethanolamine cytidylyltransferase affect embryonic and postembryonic development
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-
?
CTP + ethanolamine phosphate
diphosphate + CDP-ethanolamine
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-
-
?
CTP + ethanolamine phosphate
diphosphate + CDP-ethanolamine
enzyme activity increases during the dark and then decreases during the light period, while the mRNA level does not alter, providing evidence for posttranslational regulation
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-
?
CTP + ethanolamine phosphate
diphosphate + CDP-ethanolamine
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-
-
-
?
CTP + ethanolamine phosphate
diphosphate + CDP-ethanolamine
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-
-
?
CTP + ethanolamine phosphate
diphosphate + CDP-ethanolamine
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Pcyt2is necessary for murine development. A single Pcyt2 allele in heterozygotes can maintain phospholipid homeostasis
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-
?
CTP + ethanolamine phosphate
diphosphate + CDP-ethanolamine
-
-
-
?
CTP + ethanolamine phosphate
diphosphate + CDP-ethanolamine
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-
-
-
?
CTP + ethanolamine phosphate
diphosphate + CDP-ethanolamine
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rate-regulatory enzyme of phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway
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-
?
CTP + ethanolamine phosphate
diphosphate + CDP-ethanolamine
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catalyzes a central step in phosphatidylethanolamine synthesis
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r
CTP + ethanolamine phosphate
diphosphate + CDP-ethanolamine
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catalyzes a central step in phosphatidylethanolamine synthesis
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r
CTP + ethanolamine phosphate
diphosphate + CDP-ethanolamine
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at physiological ethanolamine concentrations, the supply of CDPethanolamine, via the expression level of CTP:phosphoethanolamine cytidylyltransferase, together with the amount of cellular diacylglycerol available to CTP:phosphoethanolamine cytidylyltransferase are major factors regulating the flux through the CDPethanolamine pathway
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-
?
CTP + ethanolamine phosphate
diphosphate + CDP-ethanolamine
-
-
-
-
?
CTP + ethanolamine phosphate
diphosphate + CDP-ethanolamine
-
-
-
-
?
CTP + ethanolamine phosphate
diphosphate + CDP-ethanolamine
-
-
-
-
?
dCTP + ethanolamine phosphate
diphosphate + dCDP-ethanolamine
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-
-
?
dCTP + ethanolamine phosphate
diphosphate + dCDP-ethanolamine
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-
-
-
?
dCTP + ethanolamine phosphate
diphosphate + dCDP-ethanolamine
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-
-
-
?
additional information
?
-
-
uses N-methylated derivatives of ethanolamine phosphate less efficiently and does not react with phosphocholine
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-
?
additional information
?
-
catalytic reaction of ECT obeys Michaelis-Menten kinetics with respect to both CTP and phosphoethanolamine
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-
?
additional information
?
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catalytic reaction of ECT obeys Michaelis-Menten kinetics with respect to both CTP and phosphoethanolamine
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-
?
additional information
?
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Pcyt2 is the main regulatory enzyme in the CDP-ethanolamine pathwa
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-
?
additional information
?
-
uses N-methylated derivatives of ethanolamine phosphate less efficiently and does not react with phosphocholine
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-
?
additional information
?
-
-
uses N-methylated derivatives of ethanolamine phosphate less efficiently and does not react with phosphocholine
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-
?
additional information
?
-
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the enzyme shows high substrate specificity for ethanolamine phosphate
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-
?
additional information
?
-
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uses N-methylated derivatives of ethanolamine phosphate less efficiently and does not react with phosphocholine
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-
?
additional information
?
-
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the enzyme shows high substrate specificity for ethanolamine phosphate
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-
?
additional information
?
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the enzyme shows high substrate specificity for ethanolamine phosphate
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-
?
