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Literature summary for 2.7.7.14 extracted from

  • Vermeulen, P.S.; Geelen, M.J.H.; van Golde, L.M.G.
    Substrate specificity of CTP: phosphoethanolamine cytidylyltransferase purified from rat liver (1994), Biochim. Biophys. Acta, 1211, 343-349.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
phosphocholine weak, competitive to phosphoethanolamine Rattus norvegicus
phosphodimethylethanolamine weak, competitive to phosphoethanolamine Rattus norvegicus
phosphomonomethylethanolamine weak, competitive to phosphoethanolamine Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.072
-
Phosphoethanolamine pH 7.8, 37°C Rattus norvegicus
0.11
-
phosphomonomethylethanolamine pH 7.8, 37°C Rattus norvegicus
6.2
-
phosphocholine pH 7.8, 37°C Rattus norvegicus
6.8
-
phosphodimethylethanolamine pH 7.8, 37°C Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + ethanolamine phosphate Rattus norvegicus
-
diphosphate + CDP-ethanolamine
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + ethanolamine phosphate
-
Rattus norvegicus diphosphate + CDP-ethanolamine
-
?
CTP + phosphocholine
-
Rattus norvegicus diphosphate + CDP-choline
-
?
CTP + phosphodimethylethanolamine
-
Rattus norvegicus diphosphate + CDP-dimethylethanolamine
-
?
CTP + phosphomonomethylethanolamine
-
Rattus norvegicus diphosphate + CDP-methylethanolamine
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
2 optima: pH 6.5 and pH 8.0 Rattus norvegicus
8
-
2 optima: pH 6.5 and pH 8.0 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.8
-
phosphodimethylethanolamine pH 7.8, 37°C Rattus norvegicus
7
-
phosphomonomethylethanolamine pH 7.8, 37°C Rattus norvegicus
52.9
-
phosphocholine pH 7.8, 37°C Rattus norvegicus