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Literature summary for 2.7.7.14 extracted from
- NMDA receptor overactivation inhibits phospholipid synthesis by decreasing choline-ethanolamine phosphotransferase activity (2003), J. Neurosci., 23, 4100-4107.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | overactivation of the NMDA receptor in neurons inhibits the enzyme, membrane damage by NMDA receptor is preceeded by inhibition of phospholipid synthesis | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Rattus norvegicus | 16020 | - |
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + ethanolamine phosphate | Rattus norvegicus | rate-regulatory enzyme of phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway | diphosphate + CDP-ethanolamine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Sprague-Dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| brain cortex | - |
Rattus norvegicus | - |
| cell culture | primary from brain cortical neurons | Rattus norvegicus | - |
| additional information | overactivation of the NMDA receptor, i.e. N-methyl-D-aspartic acid receptor, in neurons by toxic concentrations inhibits the enzyme, membrane damage by NMDA receptor is preceeded by inhibition of phospholipid synthesis | Rattus norvegicus | - |
| neuron | cortical | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + ethanolamine phosphate | - |
Rattus norvegicus | diphosphate + CDP-ethanolamine | - |
? | |
| CTP + ethanolamine phosphate | rate-regulatory enzyme of phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway | Rattus norvegicus | diphosphate + CDP-ethanolamine | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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