2.7.4.9: dTMP kinase

This is an abbreviated version!
For detailed information about dTMP kinase, go to the full flat file.

Word Map on EC 2.7.4.9

2.7.4.9

tuberculosis

nucleoside

deoxycytidine

dtdp

aztmp

medicine

drug development

Reaction

Synonyms

ATP: TMP phosphotransferase, Cdc8, deoxythymidine 5'-monophosphate kinase, deoxythymidine monophosphate kinase, dTMP kinase, dTMP kinases, dTMPK, human thymidine monophosphate kinase (hTMPK), kinase, thymidine monophosphate (phosphorylating), kinase, thymidylate (phosphorylating), ORF454, PfTMK, S. aureus thymidylate kinase, thymidine 5'-monophosphate kinase, thymidine kinase, thymidine monophosphate kinase, thymidylate kinase, thymidylate monophosphate kinase, thymidylic acid kinase, thymidylic kinase, TK1, TMK, TMP kinase, TMPK, TMPKmt, TTHA1607, TYMK

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.4.9 dTMP kinase

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Results	in table
1	Activating Compound
45422	AA Sequence
12	Application
1	CAS Registry Number
29	Cloned(Commentary)
9	Cofactor
23	Crystallization (Commentary)
179	Disease/ Diagnostics
23	General Information
8	General Stability
178	IC50 Value
502	Inhibitors
18	kcat/KM [mM/s]
198	Ki Value [mM]
101	KM Value [mM]
15	Localization
29	Metals/Ions
21	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
298	Organism
11	Pathway
232	PDB ID
9	pH Optimum
6	pH Range
3	pH Stability
29	Protein Variants
27	Purification (Commentary)
3	Reaction
4	Reaction Type
107	Reference
1	Renatured (Commentary)
23	Source Tissue
11	Specific Activity [micromol/min/mg]
4	Storage Stability
215	Substrates and Products (Substrate)
21	Subunits
99	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
14	Temperature Stability [°C]
63	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 2.7.4.9 - dTMP kinase

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100000

Strongylocentrotus intermedius

22000

22635

Mycobacterium tuberculosis

2 * 22635, electrospray ionization mass spectrometry

645207

23779

Escherichia coli

2 * 23779, electrospray ionization mass spectrometry, wild-type enzyme

645202

23794

Escherichia coli

2 * 23794, electrospray ionization mass spectrometry, G146A mutant enzyme

645202

24000

2 entries

24792

Saccharomyces cerevisiae

x * 24792, calculation from nucleotide sequence

645199

24800

Saccharomyces cerevisiae

estimated from amino acid sequence

703717

25000

2 entries

33000

Mus musculus

sucrose density gradient centrifugation

645196

36500

Equid alphaherpesvirus 4

2 * 36500, calculated from the deduced amino acid sequence, crystal structure analysis

663399

46000

Gallus gallus

gel filtration

645194

46600

Mycobacterium tuberculosis

sedimentation equilibrium ultracentrifugation

48000

gel filtration

50000

gel filtration

52000

65000

gel filtration, sucrose density gradient centrifugation

645198

additional information

Saccharomyces cerevisiae

thymidylate kinase is the product of the CDC8 gene

645199