Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.7.4.9: dTMP kinase

This is an abbreviated version!
For detailed information about dTMP kinase, go to the full flat file.

Word Map on EC 2.7.4.9

Reaction

ATP
+
dTMP
=
ADP
 +
dTDP

Synonyms

ATP: TMP phosphotransferase, Cdc8, deoxythymidine 5'-monophosphate kinase, deoxythymidine monophosphate kinase, dTMP kinase, dTMP kinases, dTMPK, human thymidine monophosphate kinase (hTMPK), kinase, thymidine monophosphate (phosphorylating), kinase, thymidylate (phosphorylating), ORF454, PfTMK, S. aureus thymidylate kinase, thymidine 5'-monophosphate kinase, thymidine kinase, thymidine monophosphate kinase, thymidylate kinase, thymidylate monophosphate kinase, thymidylic acid kinase, thymidylic kinase, TK1, TMK, TMP kinase, TMPK, TMPKmt, TTHA1607, TYMK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.4 Phosphotransferases with a phosphate group as acceptor
                2.7.4.9 dTMP kinase

IC50 Value

IC50 Value on EC 2.7.4.9 - dTMP kinase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000003 - 0.0000137
(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
0.0000003 - 0.0000183
(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
0.018 - 0.2
(R)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.0051 - 0.2
(R)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.0004 - 0.0026
(S)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.0004 - 0.0015
(S)-1-(1-(3-(3,5-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.0001 - 0.0006
(S)-1-(1-(3-(3-bromophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.001 - 0.0019
(S)-1-(1-(3-(3-chloro-4-methylphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.0001 - 0.0021
(S)-1-(1-(3-(3-chloro-5-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.00015 - 0.0012
(S)-1-(1-(3-(3-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.0004 - 0.0032
(S)-1-(1-(3-(3-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.0004 - 0.0085
(S)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.000028
(S)-2-(3-bromophenoxy)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)methyl)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.00001
(S)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-piperidin-1-yl)methyl)-2-(m-tolyloxy)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.0003 - 0.0027
(S)-5-methyl-1-(1-(3-(m-tolyloxy)benzyl)piperidin-3-yl)-pyrimidine-2,4(1H,3H)-dione
0.0013 - 0.035
1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.009 - 0.143
1-(1-(3-(4-methoxyphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.138
1-(1-benzylpiperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.00095 - 0.00096
1-(1-[[4-(3-chlorophenoxy)quinolin-2-yl]methyl]piperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
0.328
1-(1-[[4-(dimethylamino)phenyl]methyl]piperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.066
1-methyl-6-(pyridin-3-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.152
1-methyl-6-(pyridin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.2
1-methyl-6-(pyrimidin-5-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.058
1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
1.115
1-[1-(cyclohexylmethyl)piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.023
1-[1-[(1-benzofuran-2-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.0071 - 0.06045
1-[1-[(3,4-dichlorophenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
0.04
1-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.113
1-[1-[(4-methoxyphenyl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.0018
1-[1-[(7-chloro-4-phenoxyquinolin-2-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.114
1-[1-[(furan-2-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.254
1-[1-[(furan-3-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.027
1-[1-[(isoquinolin-1-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.026
1-[1-[(isoquinolin-3-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.025
1-[1-[(isoquinolin-4-yl)methyl]piperidin-4-yl]-5-methylpyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.00088
2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)acetic acid
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0013
2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)ethanesulfonic acid
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.005
2-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)propanoic acid
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.002
2-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0000001 - 0.0000005
2-(3-bromophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
0.0000003 - 0.0000013
2-(3-bromophenoxy)-4-((R)-3-ethyl-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
0.0000006 - 0.0000028
2-(3-bromophenoxy)-4-((S)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
0.0000001 - 0.0000011
2-(3-bromophenoxy)-4-(R)-(2-(1-adamantane)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
0.000003
2-(3-chlorophenoxy)-3-methoxy-4-[(1S)-1-[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]propyl]benzoic acid
Staphylococcus aureus
-
temperature not specified in the publication, pH not specified in the publication
0.0000001 - 0.0000016
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethyl)benzoic acid
0.000001 - 0.0000025
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
0.0000006 - 0.0000083
2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)piperidin-1-yl)butyl)benzoic acid
0.0000001 - 0.0000007
2-(3-chlorophenoxy)-4-((R)-2-cyclohexyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
0.0000003 - 0.0000007
2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
0.0000003 - 0.000001
2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
0.0000001 - 0.000003
2-(3-chlorophenoxy)-4-((R)-3-ethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
0.0000006 - 0.0000012
2-(3-chlorophenoxy)-4-((R)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
0.0000002 - 0.000018
2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
0.0000006 - 0.0000293
2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
0.0000002 - 0.0000135
2-(3-chlorophenoxy)-4-((S)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
0.00025
2-benzyl-3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamido)propanoic acid
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.012
2-{[3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzoyl]amino}-4-phenylbutanoic acid
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.00044
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.2
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzenesulfonamide
Pseudomonas aeruginosa
IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.2
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzonitrile
Pseudomonas aeruginosa
IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.002
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(2-(pyridin-4-yl)ethyl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.00016
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-(4-(trifluoromethyl)phenyl)propyl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.00051
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-(pyridin-3-yl)propyl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0058
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-morpholinopropyl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.00012
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(3-phenylpropyl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0062
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-(pyridin-2-ylmethyl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0029
3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-N-phenethylbenzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0026
3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamido)propanoic acid
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0024
3-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0000003
4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-piperidin-1-yl)methyl)-2-(3-(trifluoromethyl)phenoxy)benzoic acid
Streptococcus pneumoniae
-
pH and temperature not specified in the publication
0.2
4-(1-methyl -2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-benzamide
Pseudomonas aeruginosa
IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0027
4-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamido)propyl)benzoic acid
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.000002
4-[3-cyano-2-oxo-7-(1H-pyrazol-4-yl)-5,6-dihydro-1H-benzo[h]quinolin-4-yl]benzoic acid
Mycobacterium tuberculosis
pH 7.5, 37°C
0.00042
4-[3-cyano-6-(3-methoxyphenyl)-2-oxo-1H-pyridin-4-yl]benzoic acid
Mycobacterium tuberculosis
pH 7.5, 37°C
0.141
4-[[4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl]benzoic acid
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.035
4-[[4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl]benzonitrile
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.015 - 0.024
5-methyl-1-(1-(3-(3-(trifluoromethyl)phenoxy)benzyl)piperidin-3-yl)pyrimidine-2,4(1H,3H)-dione
0.142
5-methyl-1-(1-[[4-(1H-tetrazol-5-yl)phenyl]methyl]piperidin-4-yl)pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.72
5-methyl-1-(2-[methyl[(3-phenoxyphenyl)methyl]amino]ethyl)pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.01
5-methyl-1-[(3S)-1-[(3-phenoxyphenyl)methyl]piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.129
5-methyl-1-[1-(2-phenylethyl)piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.235
5-methyl-1-[1-(3-phenoxybenzoyl)piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.0029 - 0.156
5-methyl-1-[1-(3-phenoxybenzyl)piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione
0.353
5-methyl-1-[1-(4-phenoxybenzoyl)piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.072
5-methyl-1-[1-[(3-methylphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.944
5-methyl-1-[1-[(3-phenoxyphenyl)methyl]azetidin-3-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.0061
5-methyl-1-[1-[(3-phenoxyphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.168
5-methyl-1-[1-[(4-methylphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.029
5-methyl-1-[1-[(4-phenoxyphenyl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.0011 - 0.03251
5-methyl-1-[1-[(4-phenoxyquinolin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
0.038
5-methyl-1-[1-[(naphthalen-1-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.02
5-methyl-1-[1-[(naphthalen-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.098
5-methyl-1-[1-[(pyridin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.075
5-methyl-1-[1-[(pyridin-3-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.049
5-methyl-1-[1-[(pyridin-4-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.009
5-methyl-1-[1-[(quinolin-2-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.017
5-methyl-1-[1-[(quinolin-3-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.025
5-methyl-1-[1-[(quinolin-4-yl)methyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
1.91
5-methyl-1-[1-[2-(3-phenoxyphenyl)ethyl]azetidin-3-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.011
5-methyl-1-[1-[2-(3-phenoxyphenyl)ethyl]piperidin-4-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
1.14
5-methyl-1-[1-[3-(3-phenoxyphenyl)propyl]azetidin-3-yl]pyrimidine-2,4(1H,3H)-dione
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.006 - 0.059
5-methyl-1-[1-[3-(4-methylphenoxy)benzyl]piperidin-3-yl]-pyrimidine-2,4(1H,3H)-dione
0.143
5-[[4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl]pyridine-2-carboxylic acid
Mycobacterium tuberculosis
pH 7.4, temperature not specified in the publication
0.2
6-(3-(aminomethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.037
6-(3-(hydroxymethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]-pyridin-2(3H)-one
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.013
6-(3-acetylphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.063
6-(3-aminophenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.2
6-(3-fluorophenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
IC50 above 0.2 mM, in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.011
6-(3-hydroxyphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0049
6-(4-(aminomethyl)phenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.021
6-(4-hydroxyphenyl)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.14
albendazole
Wolbachia endosymbiont of Brugia malayi
pH 7.4, temperature not specified in the publication
0.01
D-2'-fluoroarabinosyl-5-methyldeoxyuridine
Bacillus anthracis
pH 7.6, 37°C
0.02
deoxy-fluorothymidine
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.75
diethylcarbamazine
Wolbachia endosymbiont of Brugia malayi
pH 7.4, temperature not specified in the publication
155
guanidine hydrochloride
Wolbachia endosymbiont of Brugia malayi
pH 7.4, 37°C
0.15
ivermectin
Wolbachia endosymbiont of Brugia malayi
pH 7.4, temperature not specified in the publication
1.2
levamisole
Wolbachia endosymbiont of Brugia malayi
pH 7.4, temperature not specified in the publication
0.00037
methyl 2-(3-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamido)propyl)benzoate
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.104
N,N-dimethyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.068
N-((1H-benzo[d]imidazol-2-yl)methyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.003
N-(2-(1H-benzo[d]imidazol-2-yl)ethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0023
N-(2-(1H-imidazol-5-yl)ethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.00088
N-(2-amino-2-oxoethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0032
N-(2-aminoethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0026
N-(2-hydroxyethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0034
N-(3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)phenyl)acetamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.00099
N-(3-(1H-imidazol-4-yl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0002
N-(3-(1H-indol-3-yl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0022
N-(3-(3-(aminomethyl)phenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0032
N-(3-(4-(aminomethyl)phenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.00012
N-(3-(4-fluorophenyl)propyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.00081
N-(3-cyclopentylpropyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0021
N-(cyanomethyl)-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo-[4,5-b]pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.001
N-benzyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.0022
N-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]-pyridin-6-yl)benzamide
Pseudomonas aeruginosa
in 40 mM HEPES, pH 8.0, 80 mM KCl, and 1.6 mM MgCl2, at 25°C
0.018
suramin
Wolbachia endosymbiont of Brugia malayi
pH 7.4, temperature not specified in the publication
0.0000002 - 0.0000008
TK-666
600
Urea
Wolbachia endosymbiont of Brugia malayi
pH 7.4, 37°C