2.7.4.9: dTMP kinase

This is an abbreviated version!
For detailed information about dTMP kinase, go to the full flat file.

Reaction

Synonyms

ATP: TMP phosphotransferase, Cdc8, deoxythymidine 5'-monophosphate kinase, deoxythymidine monophosphate kinase, dTMP kinase, dTMP kinases, dTMPK, human thymidine monophosphate kinase (hTMPK), kinase, thymidine monophosphate (phosphorylating), kinase, thymidylate (phosphorylating), ORF454, PfTMK, S. aureus thymidylate kinase, thymidine 5'-monophosphate kinase, thymidine kinase, thymidine monophosphate kinase, thymidylate kinase, thymidylate monophosphate kinase, thymidylic acid kinase, thymidylic kinase, TK1, TMK, TMP kinase, TMPK, TMPKmt, TTHA1607, TYMK

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.4 Phosphotransferases with a phosphate group as acceptor

                2.7.4.9 dTMP kinase

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Results	in table
1	Activating Compound
45422	AA Sequence
12	Application
1	CAS Registry Number
29	Cloned(Commentary)
9	Cofactor
23	Crystallization (Commentary)
179	Disease/ Diagnostics
23	General Information
8	General Stability
178	IC50 Value
502	Inhibitors
18	kcat/KM [mM/s]
198	Ki Value [mM]
101	KM Value [mM]
15	Localization
29	Metals/Ions
21	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
298	Organism
11	Pathway
232	PDB ID
9	pH Optimum
6	pH Range
3	pH Stability
29	Protein Variants
27	Purification (Commentary)
3	Reaction
4	Reaction Type
107	Reference
1	Renatured (Commentary)
23	Source Tissue
11	Specific Activity [micromol/min/mg]
4	Storage Stability
215	Substrates and Products (Substrate)
21	Subunits
99	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
14	Temperature Stability [°C]
63	Turnover Number [1/s]

pH Range

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pH Range on EC 2.7.4.9 - dTMP kinase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5 - 9

Saccharomyces cerevisiae

-

pH 5: about 45% of maximal activity, pH 6-9: optimum

645191

6

Plasmodium falciparum

-

marked drop in activity below

692915

7 - 8

Wolbachia endosymbiont of Brugia malayi

Q5GTD5

marked loss of activity above or below

737398

7 - 8.7

Escherichia coli

-

pH 7.0: about 50% of maximal activity, pH 8.7: about 40% of maximal activity

645198

7 - 9

Plasmodium falciparum

-

-

692915

7 - 9.5

Streptococcus pneumoniae

-

pH 7.0: about 40% of maximal activity, pH 9.5: about 55% of maximal activity

645203