2.7.4.22: UMP kinase
This is an abbreviated version!
For detailed information about UMP kinase, go to the full flat file.
Reaction
Synonyms
ATP:UMP phosphotransferase, HP0777 protein, More, pyrH, Rv2883c, SsUMPK, UMP kinase, UMP-kinase, UMPK, UMPKs, uridine monophosphate kinase, uridylate kinase, XC1936
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 2.7.4.22 - UMP kinase
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REACTION DIAGRAM
ATP + UMP
ADP + UDP
Q81S73
an essential metabolic step with a structure-based mechanism for the allosteric behavior of bacterial enzyme, overview
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ATP + UMP
ADP + UDP
Q81S73
an essential metabolic step with a structure-based mechanism for the allosteric behavior of bacterial enzyme, overview
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?
ATP + UMP
ADP + UDP
the enzyme regulatory mechanisms involve GTP and UTP, overview
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ATP + UMP
ADP + UDP
high substrate specificity toward UMP and ATP
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ATP + UMP
ADP + UDP
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?
ATP + UMP
ADP + UDP
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-
?
ATP + UMP
ADP + UDP
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-
-
?
ATP + UMP
ADP + UDP
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-
-
?
ATP + UMP
ADP + UDP
-
-
-
?
ATP + UMP
ADP + UDP
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-
-
?
?
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-
UMP kinase exhibits an intrinsic fluorescence, due to its unique tryptophan, decreasing with the increase of UTP concentration
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additional information
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bacterial UMP kinases are crucial enzymes that are responsible for microbial UTP biosynthesis, and bacterial UMPKs are specific for the phosphorylation of UMP only showing no dual activity in contrast to eukaryotic enzymes
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