2.7.4.22: UMP kinase

This is an abbreviated version!
For detailed information about UMP kinase, go to the full flat file.

Reaction

Synonyms

ATP:UMP phosphotransferase, HP0777 protein, More, pyrH, Rv2883c, SsUMPK, UMP kinase, UMP-kinase, UMPK, UMPKs, uridine monophosphate kinase, uridylate kinase, XC1936

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.4.22 UMP kinase

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Results	in table
72	Activating Compound
42057	AA Sequence
14	Application
1	CAS Registry Number
38	Cloned(Commentary)
7	Cofactor
15	Crystallization (Commentary)
10	General Information
25	IC50 Value
103	Inhibitors
4	kcat/KM [mM/s]
26	Ki Value [mM]
186	KM Value [mM]
5	Localization
28	Metals/Ions
30	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
68	Organism
5	Pathway
92	PDB ID
14	pH Optimum
4	pH Range
2	pH Stability
1	pI Value
72	Protein Variants
36	Purification (Commentary)
2	Reaction
4	Reaction Type
50	Reference
1	Renatured (Commentary)
135	Specific Activity [micromol/min/mg]
7	Storage Stability
83	Substrates and Products (Substrate)
38	Subunits
125	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
28	Temperature Stability [°C]
7	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.7.4.22 - UMP kinase

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ATP:UMP phosphotransferase

This enzyme is strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme UMP/CMP kinase (EC 2.7.4.14) for the same purpose [2]. This enzyme is the subject of feedback regulation, being inhibited by UTP and activated by GTP [1].