Activating Compound | Comment | Organism | Structure |
---|---|---|---|
GTP | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Cloned (Comment) | Organism |
---|---|
- |
Escherichia coli |
- |
Salmonella enterica subsp. enterica serovar Typhimurium |
Protein Variants | Comment | Organism |
---|---|---|
A122T | activity decreased to 26% of the wild-type | Salmonella enterica subsp. enterica serovar Typhimurium |
D201G | activity decreased to 16% of the wild-type, significant loss of sensitivity to activation by GTP | Salmonella enterica subsp. enterica serovar Typhimurium |
D201N/E241D | activity decreased to 1% of the wild-type | Salmonella enterica subsp. enterica serovar Typhimurium |
G232D | resistance to heat denaturation is altered, catalytic avtivity is reduced to 17% of the wild-type | Escherichia coli |
R11H | lowered catalytic activity, 45% of the wild-type, resistance to heat denaturation is impaired | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
UTP | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + UMP | Escherichia coli | - |
ADP + UDP | - |
? | |
ATP + UMP | Salmonella enterica subsp. enterica serovar Typhimurium | - |
ADP + UDP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0A7E9 | - |
- |
Escherichia coli | P0A7E9 | wild type | - |
Escherichia coli | P0A7E9 | strain KUR1244/K12 pyrH (high dose) | - |
Escherichia coli | P0A7E9 | strain KUR1244/K12 pyrH (low dose) | - |
Salmonella enterica subsp. enterica serovar Typhimurium | P65933 | serovar Typhimurum | - |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
- |
Salmonella enterica subsp. enterica serovar Typhimurium |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.003 | - |
- |
Escherichia coli |
0.034 | - |
- |
Escherichia coli |
0.1 | - |
- |
Escherichia coli |
2.4 | - |
- |
Escherichia coli |
7.2 | - |
mutant D201G | Salmonella enterica subsp. enterica serovar Typhimurium |
50 | - |
wild-type | Salmonella enterica subsp. enterica serovar Typhimurium |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + UMP | - |
Escherichia coli | ADP + UDP | - |
? | |
ATP + UMP | - |
Salmonella enterica subsp. enterica serovar Typhimurium | ADP + UDP | - |
? | |
ATP + UMP | 30°C, pH 7.4 | Escherichia coli | ADP + UDP | - |
? | |
ATP + UMP | 30°C, pH 7.4 | Salmonella enterica subsp. enterica serovar Typhimurium | ADP + UDP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UMP kinase | - |
Escherichia coli |
UMP kinase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
uridine monophosphate kinase | - |
Escherichia coli |
uridine monophosphate kinase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
55 | - |
Tm of mutant R11H | Escherichia coli |
57 | - |
Tm of mutant G232D | Escherichia coli |
63 | - |
Tm of the wild-type | Escherichia coli |
63 | - |
Tm of wild-type and mutant D201G | Salmonella enterica subsp. enterica serovar Typhimurium |