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2.7.2.3: phosphoglycerate kinase

This is an abbreviated version!
For detailed information about phosphoglycerate kinase, go to the full flat file.

Word Map on EC 2.7.2.3

Reaction

ATP
+
3-phospho-D-glycerate
=
ADP
 +
3-phospho-D-glyceroyl phosphate

Synonyms

3-PGK, 3-phosphoglycerate 1-phosphotransferase, 3-phosphoglycerate kinase, 3-phosphoglycerate phosphokinase, 3-phosphoglyceric acid kinase, 3-phosphoglyceric acid phosphokinase, 3-phosphoglyceric kinase, AbPGK, ATP-3-phospho-D-glycerate-1-phosphotransferase, ATP:3-phospho-D-glycerate 1-phosphotransferase, ATP:D-3-phosphoglycerate 1-phosphotransferase, chl-PGK, glycerate 3-phosphate kinase, glycerophosphate kinase, HacPGK1, HacPGK2, HapPGK, hPGK, HsPGK, human 3-phosphoglycerate kinase, kinase (phosphorylating), phosphoglycerate, Mfer_0156, OsPGK2, P-glycerate kinase, PAS-PGK, PfPGK, PGK, PGK 1, PGK-1, PGK-2, pgk-B, PGK1, PGK2, Pgk3, Pgk5, PGKA, PGKase-1, PGKB, PGKC, pgkp1, pgkp2, phosphoglycerate kinase, phosphoglycerate kinase 1, phosphoglycerate kinase 2, phosphoglycerate kinase B, phosphoglycerate kinase-1, phosphoglyceric acid kinase, phosphoglyceric kinase, phosphoglycerokinase, PwPGK, SjPGK, SSO0527, testis-specific phosphoglycerate kinase 2, TRSC58_02767, X chromosome-linked phosphoglycerate kinase-1

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.2 Phosphotransferases with a carboxy group as acceptor
                2.7.2.3 phosphoglycerate kinase

Source Tissue

Source Tissue on EC 2.7.2.3 - phosphoglycerate kinase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
hypoxic treatment induces the protein expression of PGK
Manually annotated by BRENDA team
-
pancreatic carcinoma cell line, low amount of enzyme compared to HT-1080 cells
Manually annotated by BRENDA team
-
of 10 cancer patients whose serum is tested, 3 of 4 with pancreatic cancer have 65-900% higher levels of PGK1 than that found in normal serum
Manually annotated by BRENDA team
-
moderate PGK1 expression
Manually annotated by BRENDA team
-
breast carcinoma cell line, reduced amount of enzyme compared to HT-1080 cells
Manually annotated by BRENDA team
-
pancreatic carcinoma cell line, low amount of enzyme compared to HT-1080 cells
Manually annotated by BRENDA team
-
predominant expression of isoform Pgk3
Manually annotated by BRENDA team
-
moderate PGK1 expression
Manually annotated by BRENDA team
-
intrauterine, high concentration. Probably the miracidia in the eggs may accumulate the enzyme to produce the energy required for swimming after hatching
Manually annotated by BRENDA team
-
from intraperitoneal cavity
Manually annotated by BRENDA team
-
single-nucleotide polymorphisms is an adaptation to the external anoxic environment
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
of adult and newborn rats
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
colon carcinoma cell line, nearly the same amount of enzyme compared to HT-1080 cells
Manually annotated by BRENDA team
-
colon carcinoma cell line, increased amount of enzyme compared to HT-1080 cells
Manually annotated by BRENDA team
-
colon carcinoma cell line, increased amount of enzyme compared to HT-1080 cells
Manually annotated by BRENDA team
-
breast carcinoma cell line, the same amount of enzyme compared to HT-1080 cells
Manually annotated by BRENDA team
-
breast carcinoma cell line, low amount of enzyme compared to HT-1080 cells
Manually annotated by BRENDA team
-
distinct expression of PGK1
Manually annotated by BRENDA team
-
surrounding the intestine and sperm ducts of adults
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
2fold higher level than in testis
Manually annotated by BRENDA team
-
strong expression of PGK1 in more than 70% of the tumors, 7.7- to 11.7fold higher expression in the tumor tissues versus the adjacent nontumor samples
Manually annotated by BRENDA team
-
normal or cancer-associated fibroblasts
Manually annotated by BRENDA team
-
clonality analysis of pulmonary sclerosis hemangioma samples with androgen receptor and phosphoglycerate kinase gene polymorphisms and an analysis of gene expression demonstrate that polygonal and surface cuboidal cells in pulmonary sclerosing hemangioma likely arise from a common progenitor
Manually annotated by BRENDA team
-
levels of PGK1 are significantly higher in pancreatic ductal adenocarcinoma patients than in the control group, patients with gastric cancer have significantly elevated serum levels of PGK1 comparable to those observed in pancreatic ductal adenocarcinoma patients. In breast cancer patients levels of PGK1 are increased only slightly, and show no significant difference in colorectal cancer patients
Manually annotated by BRENDA team
isoform PGK1 is mainly expressed in spermatogonia
Manually annotated by BRENDA team
-
pancreatic carcinoma cell line, very high amount of enzyme compared to HT-1080 cells
Manually annotated by BRENDA team
-
ovarian cancer cell line
Manually annotated by BRENDA team
-
of the mouse lower first molar. Strong expression of Pgk1 mRNA in the odontogenic epithelial cells and surrounding mesenchymal cells of the tooth germ from embryonic day 10.5 to embryonic day 18.0
Manually annotated by BRENDA team
additional information