2.7.2.3: phosphoglycerate kinase

This is an abbreviated version!
For detailed information about phosphoglycerate kinase, go to the full flat file.

Reaction

Synonyms

3-PGK, 3-phosphoglycerate 1-phosphotransferase, 3-phosphoglycerate kinase, 3-phosphoglycerate phosphokinase, 3-phosphoglyceric acid kinase, 3-phosphoglyceric acid phosphokinase, 3-phosphoglyceric kinase, AbPGK, ATP-3-phospho-D-glycerate-1-phosphotransferase, ATP:3-phospho-D-glycerate 1-phosphotransferase, ATP:D-3-phosphoglycerate 1-phosphotransferase, chl-PGK, glycerate 3-phosphate kinase, glycerophosphate kinase, HacPGK1, HacPGK2, HapPGK, hPGK, HsPGK, human 3-phosphoglycerate kinase, kinase (phosphorylating), phosphoglycerate, Mfer_0156, OsPGK2, P-glycerate kinase, PAS-PGK, PfPGK, PGK, PGK 1, PGK-1, PGK-2, pgk-B, PGK1, PGK2, Pgk3, Pgk5, PGKA, PGKase-1, PGKB, PGKC, pgkp1, pgkp2, phosphoglycerate kinase, phosphoglycerate kinase 1, phosphoglycerate kinase 2, phosphoglycerate kinase B, phosphoglycerate kinase-1, phosphoglyceric acid kinase, phosphoglyceric kinase, phosphoglycerokinase, PwPGK, SjPGK, SSO0527, testis-specific phosphoglycerate kinase 2, TRSC58_02767, X chromosome-linked phosphoglycerate kinase-1

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.2 Phosphotransferases with a carboxy group as acceptor

                2.7.2.3 phosphoglycerate kinase

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Results	in table
19	Activating Compound
53617	AA Sequence
29	Application
1	CAS Registry Number
74	Cloned(Commentary)
427	Cofactor
34	Crystallization (Commentary)
1549	Disease/ Diagnostics
11	Expression
44	General Information
24	General Stability
13	IC50 Value
298	Inhibitors
20	kcat/KM [mM/s]
81	Ki Value [mM]
427	KM Value [mM]
72	Localization
311	Metals/Ions
140	Molecular Weight [Da]
143	Natural Substrates/ Products (Substrates)
611	Organism
2	Oxidation Stability
24	Pathway
90	PDB ID
76	pH Optimum
17	pH Range
16	pH Stability
37	pI Value
2	Posttranslational Modification
78	Protein Variants
140	Purification (Commentary)
33	Reaction
1	Reaction Type
311	Reference
251	Source Tissue
117	Specific Activity [micromol/min/mg]
18	Storage Stability
544	Substrates and Products (Substrate)
194	Subunits
279	Synonyms
1	Systematic Name
76	Temperature Optimum [°C]
5	Temperature Range [°C]
63	Temperature Stability [°C]
160	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.7.2.3 - phosphoglycerate kinase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0018

5,5'-dithiobis(2-nitrobenzoic acid)

Brugia malayi

A0A0H5S3P5

at pH 8.5 and 25°C

762312

0.5 - 1.3

ADP

4 entries

0.02

albendazole

Brugia malayi

A0A0H5S3P5

at pH 8.5 and 25°C

762312

0.0008

clorsulon

Brugia malayi

A0A0H5S3P5

at pH 8.5 and 25°C

762312

-

1.4

iodoacetamide

Brugia malayi

A0A0H5S3P5

at pH 8.5 and 25°C

762312

0.05

ivermectin

Brugia malayi

A0A0H5S3P5

at pH 8.5 and 25°C

762312

0.01

N-ethylmaleimide

Brugia malayi

A0A0H5S3P5

at pH 8.5 and 25°C

762312

0.007

suramin

Plasmodium falciparum

-

IC50: 0.007 mM

661242

additional information

additional information

2 entries

-

0.5

ADP

Leishmania major

-

full-length enzyme, at pH 7.5 and 25°C

761069

0.9

ADP

Leishmania major

-

truncated enzyme, at pH 7.5 and 25°C

761069

1.1

ADP

Leishmania major

-

full-length enzyme, at pH 5.5 and 25°C

761069

1.3

ADP

Leishmania major

-

truncated enzyme, at pH 5.5 and 25°C

761069

additional information

additional information

Saccharomyces cerevisiae

-

IC50 values are predicted within a factor of ca. 4 over a 2500x range in activity

681295

-

additional information

additional information

Homo sapiens

-

the IC50 values are predicted within a factor of 2 over the 240x experimental range in activity

681295

-