Inhibitors | Comment | Organism | Structure |
---|---|---|---|
iodoacetate | - |
Mus musculus | |
N-ethylmaleimide | - |
Mus musculus | |
Urea | - |
Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | pH-dependence of Km values for the substrates in forward and reverse reaction, 2 isozymes | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
gel filtration | Mus musculus |
45000 | - |
isozymes PGKA and PGKB | Mus musculus |
47000 | - |
1 * 47000, isozymes PGKA and PGKB, SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
2 isozymes PGKA and PGKB | - |
Mus musculus | - |
DBA/2J | - |
Mus musculus DBA/2J | - |
DBA/2J | - |
Purification (Comment) | Organism |
---|---|
isozymes PGKA and PGKB | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
muscle | isozyme PGKA | Mus musculus | - |
testis | isozyme PGKB | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
260 | 450 | purified isozyme PGKB | Mus musculus |
500 | - |
purified isozyme PGKA | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 3-phospho-D-glycerate | - |
Mus musculus | ADP + 1,3-diphosphoglycerate | - |
r | |
ATP + 3-phospho-D-glycerate | - |
Mus musculus DBA/2J | ADP + 1,3-diphosphoglycerate | - |
r | |
CTP + 3-phospho-D-glycerate | 1% of the activity with ATP | Mus musculus | CDP + 1,3-diphosphoglycerate | - |
? | |
CTP + 3-phospho-D-glycerate | 1% of the activity with ATP | Mus musculus DBA/2J | CDP + 1,3-diphosphoglycerate | - |
? | |
dATP + 3-phospho-D-glycerate | - |
Mus musculus | dADP + 1,3-diphosphoglycerate | - |
? | |
dATP + 3-phospho-D-glycerate | - |
Mus musculus DBA/2J | dADP + 1,3-diphosphoglycerate | - |
? | |
GTP + 3-phospho-D-glycerate | 60% of the activity with ATP | Mus musculus | GDP + 1,3-diphosphoglycerate | - |
? | |
GTP + 3-phospho-D-glycerate | 60% of the activity with ATP | Mus musculus DBA/2J | GDP + 1,3-diphosphoglycerate | - |
? | |
UTP + 3-phospho-D-glycerate | 1% of the activity with ATP | Mus musculus | UDP + 1,3-diphosphoglycerate | - |
? | |
UTP + 3-phospho-D-glycerate | 1% of the activity with ATP | Mus musculus DBA/2J | UDP + 1,3-diphosphoglycerate | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 47000, isozymes PGKA and PGKB, SDS-PAGE | Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
40 | - |
- |
Mus musculus |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | 40 | activity of both isozymes in either reaction direction increases steadily with increasing temperature within this range | Mus musculus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
pH 6.0, 10 min: 20% loss of activity, PGKA, 80% loss of activity PGKB | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
- |
Mus musculus |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
4.7 | - |
isozyme PGKB: loss of 70% activity after 45 min, isozyme PGKA: loss of 10% activity after 45 min | Mus musculus |
9.6 | - |
isozymes PGKA and PGKB: stable for at least 30 min | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ADP | - |
Mus musculus | |
ATP | required as phosphate donor | Mus musculus | |
CTP | - |
Mus musculus | |
dATP | - |
Mus musculus | |
GTP | - |
Mus musculus | |
UTP | - |
Mus musculus |