2.6.1.7: kynurenine-oxoglutarate transaminase

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For detailed information about kynurenine-oxoglutarate transaminase, go to the full flat file.

Reaction

Synonyms

AadAT, aminoadipate aminotransferase, aminotransferase, kynurenine, aspartate aminotransferase, Bna3, CCBL2, cysteine conjugate beta-lyase 1, cysteine conjugate beta-lyase 2, glutamic-oxaloacetic transaminase 2, glutamine transaminase K, KAT, KAT I, KAT II, KAT III, KAT IV, KAT-1, KAT-I, KAT-II, KAT2, KAT3, KAT3/GTL/CCBL2, KYAT3, kynurenine 2-oxoglutarate transaminase, kynurenine aminotransferase, kynurenine aminotransferase 2, kynurenine aminotransferase 3, kynurenine aminotransferase I, kynurenine aminotransferase II, kynurenine aminotransferase III, kynurenine aminotransferase IV, kynurenine aminotransferase-1, kynurenine aminotransferase-I, kynurenine aminotransferase-IV, kynurenine aminotransferases I, kynurenine aminotransferases II, kynurenine pyruvate aminotransferase, kynurenine transaminase (cyclizing), kynurenine-2-oxoglutarate aminotransferase, kynurenine/alpha-aminoadipate aminotransferase, L-kynurenine aminotransferase, mitochondrial aspartate aminotransferase, More, PhKAT, phKAT-II, type II kynurenine aminotransferase

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.7 kynurenine-oxoglutarate transaminase

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Results	in table
5	Activating Compound
1230	AA Sequence
5	Application
1	CAS Registry Number
24	Cloned(Commentary)
42	Cofactor
21	Crystallization (Commentary)
13262	Disease/ Diagnostics
1	Expression
5	General Information
8	General Stability
40	IC50 Value
243	Inhibitors
64	kcat/KM [mM/s]
4	Ki Value [mM]
163	KM Value [mM]
42	Localization
2	Metals/Ions
34	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
385	Organism
4	Pathway
86	PDB ID
38	pH Optimum
6	pH Range
3	pH Stability
1	pI Value
4	Protein Variants
32	Purification (Commentary)
3	Reaction
1	Reaction Type
115	Reference
97	Source Tissue
23	Specific Activity [micromol/min/mg]
8	Storage Stability
291	Substrates and Products (Substrate)
27	Subunits
125	Synonyms
1	Systematic Name
20	Temperature Optimum [°C]
4	Temperature Range [°C]
13	Temperature Stability [°C]
93	Turnover Number [1/s]

General Stability

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General Stability on EC 2.6.1.7 - kynurenine-oxoglutarate transaminase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

alcohol fractionation inactivates

Rattus norvegicus

-

636606

ammonium sulfate fractionation inactivates

Rattus norvegicus

-

636606

dialysis against phosphate buffer inactivates, 2-oxoglutarate protects to some extent

Rattus norvegicus

-

636606

dialysis of the apoenzyme against Tris-HCl or imidazole-HCl buffer inactivates

Rattus norvegicus

-

636608

freeze-thawing inactivates

Rattus norvegicus

-

636606

repeated freeze-thawing inactivates enzyme irriversible in dilute solution, below 0.1 mg/ml

Hansenula schneggii

-

636613

slightly acidic buffer solutions inactivate, pyridoxal phosphate or pyridoxamine phosphate restores activity, 2-oxoglutarate protects

Rattus norvegicus

-

636606

stable in phosphate buffer supplemented with pyridoxal phosphate

Rattus norvegicus

-

636608