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2.6.1.7: kynurenine-oxoglutarate transaminase

This is an abbreviated version!
For detailed information about kynurenine-oxoglutarate transaminase, go to the full flat file.

Word Map on EC 2.6.1.7

Reaction

L-kynurenine
+
2-oxoglutarate
=
4-(2-aminophenyl)-2,4-dioxobutanoate
 +
L-glutamate

Synonyms

AadAT, aminoadipate aminotransferase, aminotransferase, kynurenine, aspartate aminotransferase, Bna3, CCBL2, cysteine conjugate beta-lyase 1, cysteine conjugate beta-lyase 2, glutamic-oxaloacetic transaminase 2, glutamine transaminase K, KAT, KAT I, KAT II, KAT III, KAT IV, KAT-1, KAT-I, KAT-II, KAT2, KAT3, KAT3/GTL/CCBL2, KYAT3, kynurenine 2-oxoglutarate transaminase, kynurenine aminotransferase, kynurenine aminotransferase 2, kynurenine aminotransferase 3, kynurenine aminotransferase I, kynurenine aminotransferase II, kynurenine aminotransferase III, kynurenine aminotransferase IV, kynurenine aminotransferase-1, kynurenine aminotransferase-I, kynurenine aminotransferase-IV, kynurenine aminotransferases I, kynurenine aminotransferases II, kynurenine pyruvate aminotransferase, kynurenine transaminase (cyclizing), kynurenine-2-oxoglutarate aminotransferase, kynurenine/alpha-aminoadipate aminotransferase, L-kynurenine aminotransferase, mitochondrial aspartate aminotransferase, More, PhKAT, phKAT-II, type II kynurenine aminotransferase

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.7 kynurenine-oxoglutarate transaminase

KCat KM Value

KCat KM Value on EC 2.6.1.7 - kynurenine-oxoglutarate transaminase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.07 - 1.75
2-oxo-4-methylthiobutyrate
0.23
2-oxoadipate
in 100 mM potassium phosphate buffer (pH 7.4), at 37°C
0.02 - 8.2
2-oxobutyrate
3.13
2-oxocaproate
in 100 mM potassium phosphate buffer (pH 7.4), at 37°C
0.04 - 5.18
2-oxocaproic acid
0.045 - 6.24
2-oxoglutarate
0.14
2-oxoisocaproic acid
in 100 mM boric acid buffer, pH 9.0, at 45°C
0.01 - 2.25
2-oxovalerate
0.45
3-hydroxy-DL-kynurenine
pH and temperature not specified in the publication
315
3-hydroxykynurenine
in 200 mM phosphate buffer, pH7.5, at 37°C
0.07
3-methyl-2-oxobutanoate
in 100 mM potassium phosphate buffer (pH 7.4), at 37°C
0.065
3-methyl-2-oxopentanoate
in 100 mM potassium phosphate buffer (pH 7.4), at 37°C
0.76
4-methyl-2-oxopentanoate
in 100 mM potassium phosphate buffer (pH 7.4), at 37°C
36.8
alpha-keto-gamma-methylthiobutyrate
in 200 mM phosphate buffer, pH7.5, at 37°C
2.54
alpha-oxo-gamma-methiol-butyric acid
in 100 mM boric acid buffer, pH 9.0, at 45°C
0.05 - 6.78
glyoxylate
0.26 - 1.48
hydroxyphenylpyruvate
1.08 - 2.07
indo-3-pyruvate
0.13
Indole-3-pyruvate
pH 7.5, 38°C
0.25
L-alanine
in 100 mM boric acid buffer, pH 9.0, at 45°C
2.095
L-asparagine
in 100 mM boric acid buffer, pH 9.0, at 45°C
1.86
L-cysteine
in 100 mM boric acid buffer, pH 9.0, at 45°C
3.24
L-glutamine
in 100 mM boric acid buffer, pH 9.0, at 45°C
2.86
L-histidine
in 100 mM boric acid buffer, pH 9.0, at 45°C
0.713 - 500
L-kynurenine
2.7
L-methionine
in 100 mM boric acid buffer, pH 9.0, at 45°C
2.45
L-phenylalanine
in 100 mM boric acid buffer, pH 9.0, at 45°C
0.72
L-serine
in 100 mM boric acid buffer, pH 9.0, at 45°C
0.5
L-tryptophan
in 100 mM boric acid buffer, pH 9.0, at 45°C
0.38
L-tyrosine
in 100 mM boric acid buffer, pH 9.0, at 45°C
0.14 - 1.37
Mercaptopyruvate
0.09 - 0.75
oxaloacetate
0.96 - 5.28
phenylpyruvate
0.04 - 116
pyruvate