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2.6.1.7: kynurenine-oxoglutarate transaminase

This is an abbreviated version!
For detailed information about kynurenine-oxoglutarate transaminase, go to the full flat file.

Word Map on EC 2.6.1.7

Reaction

L-kynurenine
+
2-oxoglutarate
=
4-(2-aminophenyl)-2,4-dioxobutanoate
 +
L-glutamate

Synonyms

AadAT, aminoadipate aminotransferase, aminotransferase, kynurenine, aspartate aminotransferase, Bna3, CCBL2, cysteine conjugate beta-lyase 1, cysteine conjugate beta-lyase 2, glutamic-oxaloacetic transaminase 2, glutamine transaminase K, KAT, KAT I, KAT II, KAT III, KAT IV, KAT-1, KAT-I, KAT-II, KAT2, KAT3, KAT3/GTL/CCBL2, KYAT3, kynurenine 2-oxoglutarate transaminase, kynurenine aminotransferase, kynurenine aminotransferase 2, kynurenine aminotransferase 3, kynurenine aminotransferase I, kynurenine aminotransferase II, kynurenine aminotransferase III, kynurenine aminotransferase IV, kynurenine aminotransferase-1, kynurenine aminotransferase-I, kynurenine aminotransferase-IV, kynurenine aminotransferases I, kynurenine aminotransferases II, kynurenine pyruvate aminotransferase, kynurenine transaminase (cyclizing), kynurenine-2-oxoglutarate aminotransferase, kynurenine/alpha-aminoadipate aminotransferase, L-kynurenine aminotransferase, mitochondrial aspartate aminotransferase, More, PhKAT, phKAT-II, type II kynurenine aminotransferase

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.7 kynurenine-oxoglutarate transaminase

KM Value

KM Value on EC 2.6.1.7 - kynurenine-oxoglutarate transaminase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
21.3 - 92.7
2-aminobutanoate
0.00241 - 5.7
2-oxo-4-methylthiobutyrate
0.01 - 20.9
2-oxoadipate
3
2-oxobutanoate
-
pH 7.5, 45°C
0.000217 - 42.2
2-oxobutyrate
1.5
2-oxocaproate
in 100 mM potassium phosphate buffer (pH 7.4), at 37°C
0.5 - 10.4
2-oxocaproic acid
0.013 - 8.1
2-oxoglutarate
1
2-oxoisocaproate
5.3
2-oxoisocaproic acid
in 100 mM boric acid buffer, pH 9.0, at 45°C
1.2 - 10.9
2-oxovalerate
1.9
3-(2-aminobenzoyl)-L-alanine
Hansenula schneggii
-
pH 8.0, 37°C
0.2062
3-hydroxykynurenine
in 200 mM phosphate buffer, pH 7.5, at 37°C
12.9 - 14.2
3-methyl-2-oxobutanoate
3.3
4-methyl-2-oxopentanoate
in 100 mM potassium phosphate buffer (pH 7.4), at 37°C
0.4
alpha-oxo-gamma-methiol-butyric acid
in 100 mM boric acid buffer, pH 9.0, at 45°C
1.2
beta-phenylpyruvate
0.4 - 18
glyoxylate
1 - 1.6
hydroxyphenylpyruvate
0.5 - 1.4
indo-3-pyruvate
3.6
Indole-3-pyruvate
pH 7.5, 38°C
1.36 - 6.3
L-3-hydroxykynurenine
6.2 - 246
L-alanine
1.4 - 23.1
L-asparagine
0.7 - 1.3
L-cysteine
5.6
L-glutamate
pH 8.0, 37°C, alpha-aminoadipate aminotransferase activity
0.7 - 3.8
L-glutamine
0.7 - 5.4
L-histidine
0.083 - 27
L-kynurenine
5 - 34.5
L-leucine
0.9 - 6.4
L-methionine
1.1 - 3.5
L-phenylalanine
3 - 32.7
L-serine
1.2 - 12.9
L-tryptophan
0.9 - 3.2
L-tyrosine
2.7
L-Vinylglycine
Hansenula schneggii
-
pH 8.0. 25°C
2.4 - 3.2
Mercaptopyruvate
0.9 - 16.8
oxaloacetate
0.6 - 1.8
phenylpyruvate
0.00085 - 0.0013
pyridoxal 5'-phosphate
0.0032
pyridoxamine 5'-phosphate
Hansenula schneggii
-
pH 8.0, 37°C
0.0175 - 12.1
pyruvate
additional information
additional information
-