Reference on EC 2.6.1.7 - kynurenine-oxoglutarate transaminase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Alberati-Giani, D.; Malherbe, P.; Khler, C.; Lang, G.; Kiefer, V.; Lahm, H.W.; Cesura, A.M.
Cloning and characterization of a soluble kynurenine aminotransferase from rat brain: identity with kidney cysteine conjugate beta-lyase
J. Neurochem.
64
1448-1455
1995
Rattus norvegicus
Cesura, A.M.; Alberati-Giani, D.; Buchli, R.; Broger, C.; Kohler, C.; Vilbois, F.; Lahm, H.W.; Heitz, M.P.; Malherbe, P.
Molecular characterization of kynurenine pathway enzymes: 3-Hydroxyanthranilic-acid dioxygenase and kynurenine aminotransferase
Adv. Exp. Med. Biol.
398
477-483
1996
Rattus norvegicus
Mason, M.
Kynurenine transaminase of rat kidney: a study of coenzyme dissociation
J. Biol. Chem.
227
61-68
1957
Rattus norvegicus
Jakoby, W.B.; Bonner, D.M.
Kynurenine transaminase from Neurospora
J. Biol. Chem.
221
689-695
1956
Neurospora crassa
Tobes, M.C.
Kynurenine-oxoglutarate aminotransferase from rat kidney
Methods Enzymol.
142
217-224
1987
Rattus norvegicus
De Antoni, A.; Costa, C.; Allegri, G.
Studies on the kynurenine adminotransferase activity in rat liver and kidney
Hoppe-Seyler's Z. Physiol. Chem.
357
1707-1712
1976
Rattus norvegicus
Noguchi, T.; Minatogawa, Y.; Okuno, E.; Nakatani, M.; Morimoto, M.; Kido, R.
Purification and characterization of kynurenine-2-oxoglutarate aminotransferase from the liver, brain and small intestine of rats
Biochem. J.
151
399-406
1975
Rattus norvegicus, Rattus norvegicus Donryu
Nakatani, M.; Morimoto, M.; Noguchi, T.; Kido, R.
Subcellular distribution and properties of kynurenine transaminase in rat liver
Biochem. J.
143
303-310
1974
Rattus norvegicus, Rattus norvegicus Donryu
Mason, M.
Effects of calcium ions and quinolinic acid on rat kidney mitochondrial kynurenine aminotransferase
Biochem. Biophys. Res. Commun.
60
64-69
1974
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Asada, Y.; Sawa, Y.; Tanizawa, K.; Soda, K.
Purification and characterization of yeast L-kynurenine aminotransferase with broad substrate specificity
J. Biochem.
99
1101-1110
1986
Hansenula schneggii
Tanizawa, K.; Asada, Y.; Soda, K.
L-Kynurenine transaminase from Hansenula schneggii
Methods Enzymol.
113
90-95
1985
Saccharomyces cerevisiae, Debaryomyces hansenii, Kluyveromyces marxianus, Diutina rugosa, Naganishia albida, Torulaspora globosa, Schwanniomyces polymorphus, Hansenula schneggii, Saccharomyces fragilis, Schwanniomyces occidentalis, Cutaneotrichosporon cutaneum
Asada, Y.; Tanizawa, K.; Yonaha, K.; Soda, K.
Deamination and gamma-addition reactions of vinylglycine catalyzed by yeast kynurenine aminotransferase, and suicidal inactivation of the enzyme during its processing
Agric. Biol. Chem.
52
2873-2878
1988
Hansenula schneggii
-
Miller, I.L.; Tsuchida, M.; Adelberg, E.A.
The transamination of kynurenine
J. Biol. Chem.
203
205-211
1953
Pseudomonas fluorescens
Real, M.D.; Ferre, J.
analysis of kynurenine transaminase activity in Drosophila by high performance liquid chromatography
Insect Biochem.
21
647-652
1991
Drosophila sordidula
-
Kido, R.; Noguchi, T.
Subcellular distribution and properties of rat liver kynurenine transaminase
Acta Vitaminol. Enzymol.
29
307-309
1975
Rattus norvegicus
Yonaha, K.; Moriguchi, M.; Hirasawa, T.; Yamamoto, T.; Soda, K.
Occurence of kynurenine aminotransferase in extracts of yeasts
Bull. Inst. Chem. Res.
53
315-318
1975
Hansenula schneggii
-
Hartline, R.A.
Kynurenine aminotransferase from kidney supernatant
Methods Enzymol.
113
664-672
1985
Rattus norvegicus
Mawal, M.R.; Mukhopadhyay, A.; Deshmukh, D.R.
Purification and properties of kynurenine aminotransferase from rat kidney
Biochem. J.
279
595-599
1991
Rattus norvegicus
-
Mawal, M.R.; Deshmukh, D.R.
alpha-Aminoadipate and kynurenine aminotransferase activities from rat kidney. Evidence for separate identity
J. Biol. Chem.
266
2573-2575
1991
Rattus norvegicus
Takeuchi, F.; Otsuka, H.; Shibata, Y.
Purification, characterization and identification of rat liver mitochondrial kynurenine aminotransferase with alpha-aminoadipate aminotransferase
Biochim. Biophys. Acta
743
323-330
1983
Rattus norvegicus
Buchli, R.; Alberati-Giani, D.; Malherbe, P.; Kohler, C.; Broger, C.; Cesura, A.M.
Cloning and functional expression of a soluble form of kynurenine/alpha-aminoadipate aminotransferase from rat kidney
J. Biol. Chem.
270
29330-29335
1995
Rattus norvegicus (Q64602)
Malherbe, P.; Alberati-Giani, D.; Koehler, C.; Cesura, A.M.
Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain
FEBS Lett.
367
141-144
1995
Rattus norvegicus (Q08415)
Baran, H.; Cairns, N.; Lubec, B.; Lubec, G.
Increased kynurenic acid levels and decreased brain kynurenine aminotransferase I in patients with Down syndrome
Life Sci.
58
1891-1899
1996
Homo sapiens
Varasi, M.; Della Torre, A.; Heidempergher, F.; Pevarello, P.; Speciale, C.; Guidetti, P.; Wells, D.R.; Schwarcz, R.
Derivatives of kynurenine as inhibitors of rat brain kynurenine aminotransferase
Eur. J. Med. Chem.
31
11-21
1996
Rattus norvegicus
-
Shibata, K.; Marugami, M.; Kondo, T.
In vivo inhibition of kynurenine aminotransferase activity by isonicotinic acid hydrazide in rats
Biosci. Biotechnol. Biochem.
60
874-876
1996
Rattus norvegicus
Okuno, E.; Nishikawa, T.; Nakamura, M.
Kynurenine aminotransferases in the rat. Localization and characterization
Adv. Exp. Med. Biol.
398
455-464
1996
Rattus norvegicus
Guidetti, P.; Okuno, E.; Schwarcz, R.
Characterization of rat brain kynurenine aminotransferases I and II
J. Neurosci. Res.
50
457-465
1997
Rattus norvegicus
Baran, H.; Amann, G.; Lubec, B.; Lubec, G.
Kynurenic acid and kynurenine aminotransferase in heart
Pediatr. Res.
41
404-410
1997
Homo sapiens
Meunpol, O.; Hall, M.R.; Kapoor, V.
Partial characterization and distribution of kynurenine aminotransferase activity in the Black Tiger prawn (Penaeus monodon)
Comp. Biochem. Physiol. B
120B
139-143
1998
Penaeus monodon
-
Knyihar-Csillik, E.; Okuno, E.; Vecsei, L.
Effects of in vivo sodium azide administration on the immunohistochemical localization of kynurenine aminotransferase in the rat brain
Neuroscience
94
269-277
1999
Rattus norvegicus
Battaglia, G.; Rassoulpour, A.; Wu, H.Q.; Hodgkins, P.S.; Kiss, C.; Nicoletti, F.; Schwarcz, R.
Some metabotropic glutamate receptor ligands reduce kynurenate synthesis in rats by intracellular inhibition of kynurenine aminotransferase II
J. Neurochem.
75
2051-2060
2000
Rattus norvegicus
Milart, P.; Urbanska, E.M.; Turski, W.A.; Paszkowski, T.; Sikorski, R.
Kynurenine aminotransferase I activity in human placenta
Placenta
22
259-261
2001
Homo sapiens
Fang, J.; Han, Q.; Li, J.
Isolation, characterization, and functional expression of kynurenine aminotransferase cDNA from the yellow fever mosquito, Aedes aegypti(1)
Insect Biochem. Mol. Biol.
32
943-950
2002
Aedes aegypti (Q95VY4)
Kwok, J.B.J.; Kapoor, R.; Gotoda, T.; Iwamoto, Y.; Iizuka, Y.; Yamada, N.; Isaacs, K.E.; Kushwaha, V.V.; Church, W.B.; Schofield, P.R.; Kapoor, V.
A Missense Mutation in Kynurenine Aminotransferase-1 in Spontaneously Hypertensive Rats
J. Biol. Chem.
277
35779-35782
2002
Rattus norvegicus (Q08415)
Csillik, A.; Knyihar, E.; Okuno, E.; Krisztin-Peva, B.; Csillik, B.; Vecsei, L.
Effect of 3-nitropropionic acid on kynurenine aminotransferase in the rat brain
Exp. Neurol.
177
233-241
2002
Rattus norvegicus
Kocki, T.; Luchowski, P.; Luchowska, E.; Wielosz, M.; Turski, W.A.; Urbanska, E.M.
L-cysteine sulphinate, endogenous sulphur-containing amino acid, inhibits rat brain kynurenic acid production via selective interference with kynurenine aminotransferase II
Neurosci. Lett.
346
97-100
2003
Rattus norvegicus
Mosca, M.; Croci, C.; Mostardini, M.; Breton, J.; Malyszko, J.; Avanzi, N.; Toma, S.; Benatti, L.; Gatti, S.
Tissue expression and translational control of rat kynurenine aminotransferase/glutamine transaminase K mRNAs
Biochim. Biophys. Acta
1628
1-10
2003
Homo sapiens, Rattus norvegicus (Q08415)
Chon, H.; Matsumura, H.; Shimizu, S.; Maeda, N.; Koga, Y.; Takano, K.; Kanaya, S.
Overproduction and preliminary crystallographic study of a human kynurenine aminotransferase II homologue from Pyrococcus horikoshii OT3
Acta Crystallogr. Sect. F
F61
319-322
2005
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Han, Q.; Li, J.
pH dependence, substrate specificity and inhibition of human kynurenine aminotransferase I
Eur. J. Biochem.
271
4804-4814
2004
Homo sapiens
Han, Q.; Gao, Y.G.; Robinson, H.; Ding, H.; Wilson, S.; Li, J.
Crystal structures of Aedes aegypti kynurenine aminotransferase
FEBS J.
272
2198-2206
2005
Aedes aegypti
Han, Q.; Li, J.
Cysteine and keto acids modulate mosquito kynurenine aminotransferase catalyzed kynurenic acid production
FEBS Lett.
577
381-385
2004
Aedes aegypti (Q95VY4)
Rossi, F.; Han, Q.; Li, J.; Rizzi, M.
Crystal structure of human kynurenine aminotransferase I
J. Biol. Chem.
279
50214-50220
2004
Homo sapiens (Q16773), Homo sapiens
Wejksza, K.; Rzeski, W.; Okuno, E.; Kandefer-Szerszen, M.; Albrecht, J.; Turski, W.A.
Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in oligodendrocyte cell line (OLN-93)
Neurochem. Res.
30
963-968
2005
Rattus norvegicus
Zarnowski, T.; Rejdak, R.; Zagorski, Z.; Juenemann, A.G.; Zrenner, E.; Kocki, T.; Urbanska, E.M.; Turski, W.A.
Content of kynurenic acid and activity of kynurenine aminotransferases in mammalian eyes
Ophthalmic Res.
36
124-128
2004
Bos taurus, Oryctolagus cuniculus, Homo sapiens
Luchowska, E.; Luchowski, P.; Sarnowska, A.; Wielosz, M.; Turski, W.A.; Urbanska, E.M.
Endogenous level of kynurenic acid and activities of kynurenine aminotransferases following transient global ischemia in the gerbil hippocampus
Pol. J. Pharmacol.
55
443-447
2003
Meriones unguiculatus
Knyihar-Csillik, E.; Chadaide, Z.; Mihaly, A.; Krisztin-Peva, B.; Fenyo, R.; Vecsei, L.
Effect of 6-hydroxydopamine treatment on kynurenine aminotransferase-I (KAT-I) immunoreactivity of neurons and glial cells in the rat substantia nigra
Acta Neuropathol.
112
127-137
2006
Rattus norvegicus (Q08415)
Kapoor, R.; Lim, K.S.; Cheng, A.; Garrick, T.; Kapoor, V.
Preliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1)
Brain Res.
1106
205-210
2006
Homo sapiens (Q16773)
Rejdak, R.; Rummelt, C.; Zrenner, E.; Grieb, P.; Zarnowski, T.; Okuno, E.; Schlotzer-Schrehardt, U.; Naumann, G.O.; Kruse, F.; Junemann, A.G.
Immunohistochemical identification of kynurenine aminotransferases in corpora amylacea in the human retina and optic nerve
Folia Neuropathol.
45
66-71
2007
Homo sapiens, Homo sapiens (Q16773), Homo sapiens (Q8N5Z0)
Yu, P.; Li, Z.; Zhang, L.; Tagle, D.A.; Cai, T.
Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family
Gene
365
111-118
2006
Rattus norvegicus (Q58FK9), Homo sapiens (Q6YP21), Homo sapiens, Mus musculus (Q71RI9), Mus musculus
Hartai, Z.; Klivenyi, P.; Janaky, T.; Penke, B.; Dux, L.; Vecsei, L.
Kynurenine metabolism in plasma and in red blood cells in Parkinsons disease
J. Neurol. Sci.
239
31-35
2005
Homo sapiens (Q16773), Homo sapiens (Q8N5Z0), Homo sapiens
Rzeski, W.; Kocki, T.; Dybel, A.; Wejksza, K.; Zdzisinska, B.; Kandefer-Szerszen, M.; Turski, W.A.; Okuno, E.; Albrecht, J.
Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in cultured cerebral cortical neurons
J. Neurosci. Res.
80
677-682
2005
Rattus norvegicus (Q08415), Rattus norvegicus (Q64602)
Chon, H.; Matsumura, H.; Koga, Y.; Takano, K.; Kanaya, S.
Crystal structure of a human kynurenine aminotransferase II homologue from Pyrococcus horikoshii OT3 at 2.20.ANG. resolution
Proteins
61
685-688
2005
Pyrococcus horikoshii
Wogulis, M.; Chew, E.R.; Donohoue, P.D.; Wilson, D.K.
Identification of formyl kynurenine formamidase and kynurenine aminotransferase from Saccharomyces cerevisiae using crystallographic, bioinformatic and biochemical evidence
Biochemistry
47
1608-1621
2008
Saccharomyces cerevisiae (P47039)
Han, Q.; Gao, Y.G.; Robinson, H.; Li, J.
Structural insight into the mechanism of substrate specificity of Aedes kynurenine aminotransferase
Biochemistry
47
1622-1630
2008
Aedes aegypti, Homo sapiens
Rossi, F.; Garavaglia, S.; Montalbano, V.; Walsh, M.A.; Rizzi, M.
Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia
J. Biol. Chem.
283
3559-3566
2008
Homo sapiens
Han, Q.; Robinson, H.; Li, J.
Crystal structure of human kynurenine aminotransferase II
J. Biol. Chem.
283
3567-3573
2008
Homo sapiens (Q8N5Z0), Homo sapiens
Bellocchi, D.; Macchiarulo, A.; Carotti, A.; Pellicciari, R.
Quantum mechanics/molecular mechanics (QM/MM) modeling of the irreversible transamination of L-kynurenine to kynurenic acid: the round dance of kynurenine aminotransferase II
Biochim. Biophys. Acta
1794
1802-1812
2009
Homo sapiens
Han, Q.; Cai, T.; Tagle, D.A.; Robinson, H.; Li, J.
Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II
Biosci. Rep.
28
205-215
2008
Homo sapiens (Q8N5Z0), Homo sapiens
Rozsa, E.; Robotka, H.; Nagy, D.; Farkas, T.; Sas, K.; Vecsei, L.; Toldi, J.
The pentylenetetrazole-induced activity in the hippocampus can be inhibited by the conversion of L-kynurenine to kynurenic acid: an in vitro study
Brain Res. Bull.
76
474-479
2008
Rattus norvegicus
Han, Q.; Cai, T.; Tagle, D.A.; Li, J.
Structure, expression, and function of kynurenine aminotransferases in human and rodent brains
Cell. Mol. Life Sci.
67
353-368
2010
Homo sapiens, Mus musculus, Rattus norvegicus
Fukushima, T.; Sone, Y.; Mitsuhashi, S.; Tomiya, M.; Toyooka, T.
Alteration of kynurenic acid concentration in rat plasma following optically pure kynurenine administration: a comparative study between enantiomers
Chirality
21
468-472
2009
Rattus norvegicus
Rossi, F.; Schwarcz, R.; Rizzi, M.
Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis
Curr. Opin. Struct. Biol.
18
748-755
2008
Homo sapiens, Rattus norvegicus
Han, Q.; Robinson, H.; Cai, T.; Tagle, D.A.; Li, J.
Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K
J. Med. Chem.
52
2786-2793
2009
Homo sapiens (Q16773), Homo sapiens
Amori, L.; Guidetti, P.; Pellicciari, R.; Kajii, Y.; Schwarcz, R.
On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo
J. Neurochem.
109
316-325
2009
Rattus norvegicus
Han, Q.; Robinson, H.; Cai, T.; Tagle, D.A.; Li, J.
Biochemical and structural properties of mouse kynurenine aminotransferase III
Mol. Cell. Biol.
29
784-793
2009
Mus musculus (Q71RI9), Mus musculus
Battsetseg, B.; Boldbaatar, D.; Battur, B.; Xuan, X.; Fujisaki, K.
Cloning and molecular characterization of tick kynurenine aminotransferase (HlKAT) from Haemaphysalis longicornis (Acari: Ixodidae)
Parasitol. Res.
105
669-679
2009
Haemaphysalis longicornis (B1B6U5)
Wong, J.; Ray, W.J.; Kornilova, A.Y.
Development of a microplate fluorescence assay for kynurenine aminotransferase
Anal. Biochem.
409
183-188
2011
Homo sapiens
Akladios, F.N.; Nadvi, N.A.; Park, J.; Hanrahan, J.R.; Kapoor, V.; Gorrell, M.D.; Church, W.B.
Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I
Bioorg. Med. Chem. Lett.
22
1579-1581
2012
Homo sapiens
Han, Q.; Robinson, H.; Cai, T.; Tagle, D.A.; Li, J.
Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV
Biosci. Rep.
31
323-332
2011
Mus musculus (P05202), Mus musculus
Han, Q.; Cai, T.; Tagle, D.; Li, J.
Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases
BMC Biochem.
11
0019
2010
Mus musculus (P05202), Mus musculus (Q71RI9), Mus musculus (Q8BTY1), Mus musculus (Q9WVM8), Mus musculus
Casazza, V.; Rossi, F.; Rizzi, M.
Biochemical and structural investigations on kynurenine aminotransferase II: an example of conformation-driven species-specific inhibition?
Curr. Top. Med. Chem.
11
148-157
2011
Homo sapiens, Rattus norvegicus
Passera, E.; Campanini, B.; Rossi, F.; Casazza, V.; Rizzi, M.; Pellicciari, R.; Mozzarelli, A.
Human kynurenine aminotransferase II--reactivity with substrates and inhibitors
FEBS J.
278
1882-1900
2011
Homo sapiens
Rossi, F.; Valentina, C.; Garavaglia, S.; Sathyasaikumar, K.V.; Schwarcz, R.; Kojima, S.; Okuwaki, K.; Ono, S.; Kajii, Y.; Rizzi, M.
Crystal structure-based selective targeting of the pyridoxal 5-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement
J. Med. Chem.
53
5684-5689
2010
Homo sapiens (Q8N5Z0), Homo sapiens
Okada, K.; Angkawidjaja, C.; Koga, Y.; Takano, K.; Kanaya, S.
Characteristic features of kynurenine aminotransferase allosterically regulated by (alpha)-ketoglutarate in cooperation with kynurenine
PLoS ONE
7
e40307
2012
Pyrococcus horikoshii, Pyrococcus horikoshii OT-3
Okada, K.; Angkawidjaja, C.; Koga, Y.; Kanaya, S.
Structural and mechanistic insights into the kynurenine aminotransferase-mediated excretion of kynurenic acid
J. Struct. Biol.
185
257-266
2014
Pyrococcus horikoshii (O57946), Pyrococcus horikoshii, Pyrococcus horikoshii OT-3 (O57946)
Lu, H.; Kopcho, L.; Ghosh, K.; Witmer, M.; Parker, M.; Gupta, S.; Paul, M.; Krishnamurthy, P.; Laksmaiah, B.; Xie, D.; Tredup, J.; Zhang, L.; Abell, L.M.
Development of a RapidFire mass spectrometry assay and a fluorescence assay for the discovery of kynurenine aminotransferase II inhibitors to treat central nervous system disorders
Anal. Biochem.
501
56-65
2016
Homo sapiens (Q8N5Z0), Homo sapiens
Nematollahi, A.; Sun, G.; Harrop, S.J.; Hanrahan, J.R.; Church, W.B.
Structure of the PLP-form of the human kynurenine aminotransferase II in a novel spacegroup at 1.83 A resolution
Int. J. Mol. Sci.
17
446
2016
Homo sapiens (Q8N5Z0), Homo sapiens
Pinto, J.T.; Krasnikov, B.F.; Alcutt, S.; Jones, M.E.; Dorai, T.; Villar, M.T.; Artigues, A.; Li, J.; Cooper, A.J.
Kynurenine aminotransferase III and glutamine transaminase L are identical enzymes that have cysteine S-conjugate beta-lyase activity and can transaminate L-selenomethionine
J. Biol. Chem.
289
30950-30961
2014
Homo sapiens (Q6YP21), Homo sapiens
Linderholm, K.R.; Alm, M.T.; Larsson, M.K.; Olsson, S.K.; Goiny, M.; Hajos, M.; Erhardt, S.; Engberg, G.
Inhibition of kynurenine aminotransferase II reduces activity of midbrain dopamine neurons
Neuropharmacology
102
42-47
2016
Rattus norvegicus
Sun, G.; Nematollahi, A.; Nadvi, N.A.; Kwan, A.H.; Jeffries, C.M.; Church, W.B.
Expression, purification and crystallization of human kynurenine aminotransferase 2 exploiting a highly optimized codon set
Protein Expr. Purif.
121
41-45
2016
Homo sapiens (Q8N5Z0), Homo sapiens
Yang, C.; Zhang, L.; Han, Q.; Liao, C.; Lan, J.; Ding, H.; Zhou, H.; Diao, X.; Li, J.
Kynurenine aminotransferase 3/glutamine transaminase L/cysteine conjugate beta-lyase 2 is a major glutamine transaminase in the mouse kidney
Biochem. Biophys. Rep.
8
234-241
2016
Mus musculus
Kalliokoski, T.; Rummakko, P.; Rantanen, M.; Blaesse, M.; Augustin, M.; Ummenthala, G.R.; Choudhary, S.; Venaelaeinen, J.
Discovery of sulfonamides and 9-oxo-2,8-diazaspiro[5,5]undecane-2-carboxamides as human kynurenine aminotransferase 2 (KAT2) inhibitors
Bioorg. Med. Chem. Lett.
30
127060
2020
Homo sapiens (Q8N5Z0), Homo sapiens
Wyckelsma, V.L.; Lindkvist, W.; Venckunas, T.; Brazaitis, M.; Kamandulis, S.; Paeaesuke, M.; Ereline, J.; Westerblad, H.; Andersson, D.C.
Kynurenine aminotransferase isoforms display fiber-type specific expression in young and old human skeletal muscle
Exp. Gerontol.
134
110880
2020
Homo sapiens, Homo sapiens (Q6YP21), Homo sapiens (Q8N5Z0)
Rossi, F.; Miggiano, R.; Ferraris, D.M.; Rizzi, M.
The synthesis of kynurenic acid in mammals an updated kynurenine aminotransferase structural KATalogue
Front. Mol. Biosci.
6
7-7
2019
Mus musculus (P05202), Mus musculus (Q71RI9), Homo sapiens (Q16773), Homo sapiens (Q8N5Z0), Homo sapiens
Jayawickrama, G.; Nematollahi, A.; Sun, G.; Church, W.
Improvement of kynurenine aminotransferase-II inhibitors guided by mimicking sulfate esters
PLoS ONE
13
e0196404
2018
Homo sapiens (Q8N5Z0), Homo sapiens
Nadvi, N.A.; Salam, N.K.; Park, J.; Akladios, F.N.; Kapoor, V.; Collyer, C.A.; Gorrell, M.D.; Church, W.B.
High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate
Protein Sci.
26
727-736
2017
Homo sapiens (Q16773), Homo sapiens
Jayawickrama, G.S.; Nematollahi, A.; Sun, G.; Gorrell, M.D.; Church, W.B.
Inhibition of human kynurenine aminotransferase isozymes by estrogen and its derivatives
Sci. Rep.
7
17559
2017
Homo sapiens (Q16773), Homo sapiens (Q8N5Z0), Homo sapiens
Yoshida, Y.; Fujigaki, H.; Kato, K.; Yamazaki, K.; Fujigaki, S.; Kunisawa, K.; Yamamoto, Y.; Mouri, A.; Oda, A.; Nabeshima, T.; Saito, K.
Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues
Sci. Rep.
9
10243
2019
Homo sapiens (Q8N5Z0)
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