2.6.1.7: kynurenine-oxoglutarate transaminase

This is an abbreviated version!
For detailed information about kynurenine-oxoglutarate transaminase, go to the full flat file.

Reaction

Synonyms

AadAT, aminoadipate aminotransferase, aminotransferase, kynurenine, aspartate aminotransferase, Bna3, CCBL2, cysteine conjugate beta-lyase 1, cysteine conjugate beta-lyase 2, glutamic-oxaloacetic transaminase 2, glutamine transaminase K, KAT, KAT I, KAT II, KAT III, KAT IV, KAT-1, KAT-I, KAT-II, KAT2, KAT3, KAT3/GTL/CCBL2, KYAT3, kynurenine 2-oxoglutarate transaminase, kynurenine aminotransferase, kynurenine aminotransferase 2, kynurenine aminotransferase 3, kynurenine aminotransferase I, kynurenine aminotransferase II, kynurenine aminotransferase III, kynurenine aminotransferase IV, kynurenine aminotransferase-1, kynurenine aminotransferase-I, kynurenine aminotransferase-IV, kynurenine aminotransferases I, kynurenine aminotransferases II, kynurenine pyruvate aminotransferase, kynurenine transaminase (cyclizing), kynurenine-2-oxoglutarate aminotransferase, kynurenine/alpha-aminoadipate aminotransferase, L-kynurenine aminotransferase, mitochondrial aspartate aminotransferase, More, PhKAT, phKAT-II, type II kynurenine aminotransferase

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.7 kynurenine-oxoglutarate transaminase

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Results	in table
5	Activating Compound
1230	AA Sequence
5	Application
1	CAS Registry Number
24	Cloned(Commentary)
42	Cofactor
21	Crystallization (Commentary)
13262	Disease/ Diagnostics
1	Expression
5	General Information
8	General Stability
40	IC50 Value
243	Inhibitors
64	kcat/KM [mM/s]
4	Ki Value [mM]
163	KM Value [mM]
42	Localization
2	Metals/Ions
34	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
385	Organism
4	Pathway
86	PDB ID
38	pH Optimum
6	pH Range
3	pH Stability
1	pI Value
4	Protein Variants
32	Purification (Commentary)
3	Reaction
1	Reaction Type
115	Reference
97	Source Tissue
23	Specific Activity [micromol/min/mg]
8	Storage Stability
291	Substrates and Products (Substrate)
27	Subunits
125	Synonyms
1	Systematic Name
20	Temperature Optimum [°C]
4	Temperature Range [°C]
13	Temperature Stability [°C]
93	Turnover Number [1/s]

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

38.3 - 317

2-aminobutanoate

2 entries

0.16 - 4.27

2-oxo-4-methylthiobutyrate

3 entries

4.84

2-oxoadipate

Homo sapiens

Q8N5Z0

in 100 mM potassium phosphate buffer (pH 7.4), at 37°C

702779

234

2-oxobutanoate

Homo sapiens

-

pH 7.5, 45°C

658649

0.0018 - 3.49

2-oxobutyrate

4 entries

4.83

2-oxocaproate

Homo sapiens

Q8N5Z0

in 100 mM potassium phosphate buffer (pH 7.4), at 37°C

702779

0.41 - 2.59

2-oxocaproic acid

2 entries

0.37 - 7.67

2-oxoglutarate

3 entries

296

2-oxoisocaproate

Homo sapiens

-

pH 7.5, 45°C

658649

0.74

2-oxoisocaproic acid

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

0.13 - 2.7

2-oxovalerate

3 entries

65.12

3-hydroxykynurenine

Haemaphysalis longicornis

B1B6U5

in 200 mM phosphate buffer, pH 7.5, at 37°C

706068

0.92

3-methyl-2-oxobutanoate

Homo sapiens

Q8N5Z0

in 100 mM potassium phosphate buffer (pH 7.4), at 37°C

702779

0.92

3-methyl-2-oxopentanoate

Homo sapiens

Q8N5Z0

in 100 mM potassium phosphate buffer (pH 7.4), at 37°C

702779

2.51

4-methyl-2-oxopentanoate

Homo sapiens

Q8N5Z0

in 100 mM potassium phosphate buffer (pH 7.4), at 37°C

702779

1.02

alpha-oxo-gamma-methiol-butyric acid

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

0.19 - 263

glyoxylate

4 entries

0.39 - 1.48

hydroxyphenylpyruvate

3 entries

1.03 - 1.49

indo-3-pyruvate

2 entries

0.49

Indole-3-pyruvate

Mus musculus

P05202

pH 7.5, 38°C

721881

1.53 - 1540

L-alanine

2 entries

2.93 - 230

L-asparagine

3 entries

1.3 - 206

L-cysteine

3 entries

2.27 - 561

L-glutamine

3 entries

2 - 168

L-histidine

3 entries

1.8 - 201

L-kynurenine

8 entries

339 - 758

L-leucine

2 entries

2.43 - 215

L-methionine

3 entries

2.7 - 283

L-phenylalanine

3 entries

2.17 - 345

L-serine

2 entries

3.57 - 283

L-tryptophan

3 entries

1.03 - 139

L-tyrosine

3 entries

0.44 - 234

Mercaptopyruvate

4 entries

0.065 - 143

oxaloacetate

4 entries

0.63 - 110

phenylpyruvate

5 entries

0.36 - 29

pyruvate

5 entries

38.3

2-aminobutanoate

Homo sapiens

-

pH 7.5, 45°C

658649

317

2-aminobutanoate

Aedes aegypti

Q95VY4

pH 8.5, 45°C

658748

0.16

2-oxo-4-methylthiobutyrate

Haemaphysalis longicornis

B1B6U5

in 200 mM phosphate buffer, pH 7.5, at 37°C

706068

0.41

2-oxo-4-methylthiobutyrate

Mus musculus

P05202

pH 7.5, 38°C

721881

4.27

2-oxo-4-methylthiobutyrate

Homo sapiens

Q8N5Z0

in 100 mM potassium phosphate buffer (pH 7.4), at 37°C

702779

0.0018

2-oxobutyrate

Haemaphysalis longicornis

B1B6U5

in 200 mM phosphate buffer, pH 7.5, at 37°C

706068

0.69

2-oxobutyrate

Mus musculus

P05202

pH 7.5, 38°C

721881

2.93

2-oxobutyrate

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

3.49

2-oxobutyrate

Homo sapiens

Q8N5Z0

in 100 mM potassium phosphate buffer (pH 7.4), at 37°C

702779

0.41

2-oxocaproic acid

Mus musculus

P05202

pH 7.5, 38°C

721881

2.59

2-oxocaproic acid

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

0.37

2-oxoglutarate

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

0.53

2-oxoglutarate

Mus musculus

P05202

pH 7.5, 38°C

721881

7.67

2-oxoglutarate

Homo sapiens

Q8N5Z0

in 100 mM potassium phosphate buffer (pH 7.4), at 37°C

702779

0.13

2-oxovalerate

Mus musculus

P05202

pH 7.5, 38°C

721881

2.66

2-oxovalerate

Homo sapiens

Q8N5Z0

in 100 mM potassium phosphate buffer (pH 7.4), at 37°C

702779

2.7

2-oxovalerate

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

0.19

glyoxylate

Mus musculus

P05202

pH 7.5, 38°C

721881

2.71

glyoxylate

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

3.64

glyoxylate

Homo sapiens

Q8N5Z0

in 100 mM potassium phosphate buffer (pH 7.4), at 37°C

702779

263

glyoxylate

Homo sapiens

-

pH 7.5, 45°C

658649

0.39

hydroxyphenylpyruvate

Homo sapiens

Q8N5Z0

in 100 mM potassium phosphate buffer (pH 7.4), at 37°C

702779

0.41

hydroxyphenylpyruvate

Mus musculus

P05202

pH 7.5, 38°C

721881

1.48

hydroxyphenylpyruvate

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

1.03

indo-3-pyruvate

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

1.49

indo-3-pyruvate

Homo sapiens

Q8N5Z0

in 100 mM potassium phosphate buffer (pH 7.4), at 37°C

702779

1.53

L-alanine

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

1540

L-alanine

Aedes aegypti

Q95VY4

pH 8.5, 45°C

658748

2.93

L-asparagine

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

14.4

L-asparagine

Homo sapiens

-

pH 7.5, 45°C

658649

230

L-asparagine

Aedes aegypti

Q95VY4

pH 8.5, 45°C

658748

1.3

L-cysteine

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

9.6

L-cysteine

Homo sapiens

-

pH 7.5, 45°C

658649

206

L-cysteine

Aedes aegypti

Q95VY4

pH 8.5, 45°C

658748

2.27

L-glutamine

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

440

L-glutamine

Homo sapiens

-

pH 7.5, 45°C

658649

561

L-glutamine

Aedes aegypti

Q95VY4

pH 8.5, 45°C

658748

2

L-histidine

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

143

L-histidine

Homo sapiens

-

pH 7.5, 45°C

658649

168

L-histidine

Aedes aegypti

Q95VY4

pH 8.5, 45°C

658748

1.8

L-kynurenine

Homo sapiens

-

continuous assay, pH 7.5, 45°C

722236

2.2

L-kynurenine

Homo sapiens

-

discontinuous assay, pH 7.5, 45°C

722236

2.3

L-kynurenine

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

4.6

L-kynurenine

Homo sapiens

Q8N5Z0

mass spectrometry assay, pH 7.5, temperature not specified in the publication

737437

9.76

L-kynurenine

Homo sapiens

Q8N5Z0

in 100 mM potassium phosphate buffer (pH 7.4), at 37°C

702779

55.5

L-kynurenine

Haemaphysalis longicornis

B1B6U5

in 200 mM phosphate buffer, pH 7.5, at 37°C

706068

172

L-kynurenine

Aedes aegypti

Q95VY4

pH 8.5, 45°C

658748

201

L-kynurenine

Homo sapiens

-

pH 7.5, 45°C

658649

339

L-leucine

Homo sapiens

-

pH 7.5, 45°C

658649

758

L-leucine

Aedes aegypti

Q95VY4

pH 8.5, 45°C

658748

2.43

L-methionine

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

163

L-methionine

Aedes aegypti

Q95VY4

pH 8.5, 45°C

658748

215

L-methionine

Homo sapiens

-

pH 7.5, 45°C

658649

2.7

L-phenylalanine

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

91

L-phenylalanine

Homo sapiens

-

pH 7.5, 45°C

658649

283

L-phenylalanine

Aedes aegypti

Q95VY4

pH 8.5, 45°C

658748

2.17

L-serine

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

345

L-serine

Aedes aegypti

Q95VY4

pH 8.5, 45°C

658748

3.57

L-tryptophan

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

43.1

L-tryptophan

Homo sapiens

-

pH 7.5, 45°C

658649

283

L-tryptophan

Aedes aegypti

Q95VY4

pH 8.5, 45°C

658748

1.03

L-tyrosine

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

91

L-tyrosine

Homo sapiens

-

pH 7.5, 45°C

658649

139

L-tyrosine

Aedes aegypti

Q95VY4

pH 8.5, 45°C

658748

0.44

Mercaptopyruvate

Mus musculus

P05202

pH 7.5, 38°C

721881

3.28

Mercaptopyruvate

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

3.59

Mercaptopyruvate

Homo sapiens

Q8N5Z0

in 100 mM potassium phosphate buffer (pH 7.4), at 37°C

702779

234

Mercaptopyruvate

Homo sapiens

-

pH 7.5, 45°C

658649

0.065

oxaloacetate

Homo sapiens

Q8N5Z0

in 100 mM potassium phosphate buffer (pH 7.4), at 37°C

702779

0.32

oxaloacetate

Mus musculus

P05202

pH 7.5, 38°C

721881

3.68

oxaloacetate

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

143

oxaloacetate

Homo sapiens

-

pH 7.5, 45°C

658649

0.63

phenylpyruvate

Mus musculus

P05202

pH 7.5, 38°C

721881

2.53

phenylpyruvate

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

3.17

phenylpyruvate

Mus musculus

-

recombinant enzyme, pH 7.5, 38°C

746952

4.73

phenylpyruvate

Homo sapiens

Q8N5Z0

in 100 mM potassium phosphate buffer (pH 7.4), at 37°C

702779

110

phenylpyruvate

Homo sapiens

-

pH 7.5, 45°C

658649

0.36

pyruvate

Homo sapiens

Q8N5Z0

in 100 mM potassium phosphate buffer (pH 7.4), at 37°C

702779

0.37

pyruvate

Mus musculus

P05202

pH 7.5, 38°C

721881

1.87

pyruvate

Mus musculus

Q71RI9

in 100 mM boric acid buffer, pH 9.0, at 45°C

705702

2.02

pyruvate

Haemaphysalis longicornis

B1B6U5

in 200 mM phosphate buffer, pH 7.5, at 37°C

706068

29

pyruvate

Homo sapiens

-

pH 7.5, 45°C

658649