2.4.1.252: GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase

This is an abbreviated version!
For detailed information about GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase, go to the full flat file.

Reaction

Synonyms

AceA, alpha-mannosyltransferase AceA, GDP-mannosyltransferase, gumH

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.252 GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
117	AA Sequence
2	Application
4	Cloned(Commentary)
8	General Information
1	Inhibitors
1	Localization
1	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
10	Organism
2	Pathway
5	Protein Variants
1	Purification (Commentary)
1	Reaction
10	Reference
13	Substrates and Products (Substrate)
1	Subunits
9	Synonyms
1	Systematic Name

Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Substrates Products on EC 2.4.1.252 - GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Substrate/Product Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

GDP-mannose + cellobiose-diphosphate-polyprenol carrier lipid

GDP + D-mannose-alpha-(1-3)-cellobiose-diphosphate-polyprenol carrier lipid

Xylella fastidiosa

-

GumH enzyme is an alpha-1,3-mannosyltransferase responsible for the transfer of mannose from GDP-mannose to the cellobiose-diphosphate-polyprenol carrier lipid during the assembly of the tetrasaccharide repeat unit of the exopolysaccharide fastidian gum

711062

-

-

?

GDP-mannose + D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol

GDP + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol

5 entries

GDP-mannose + D-Glc-beta-(1->4)-Glc-alpha-1-diphosphophytanol

GDP + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphophytanol

Komagataeibacter xylinus

-

synthetic phytanyl-pyrophosphate-linked cellobiose functions as an acceptor for the AceA mannosyltransferase reaction in vitro. Neither the chain length nor the saturation state, notably of the first isoprene unit, are critical to the AceA mannosyltransferase activity

636760

-

-

?

GDP-mannose + D-Glc-beta-(1->4)-Glc-alpha-1-diphosphopolyprenol

GDP + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphopolyprenol

2 entries

additional information

?

-

2 entries

GDP-mannose + D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol

GDP + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol

Komagataeibacter xylinus

-

-

636760

-

-

?

GDP-mannose + D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol

GDP + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol

Komagataeibacter xylinus

Q44571

-

704253

-

-

?

GDP-mannose + D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol

GDP + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol

Komagataeibacter xylinus

-

the enzyme is involved in the biosynthesis of the exopolysaccharide acetan

636760, 705743

-

-

?

GDP-mannose + D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol

GDP + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol

Komagataeibacter xylinus

-

AceA is not able to use free cellobiose as a substrate, indicating that the pyrophosphate-lipid moiety is needed for enzymatic activity

704396, 705743

characterisation of the in vitro reaction product

-

?

GDP-mannose + D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol

GDP + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol

Xanthomonas campestris

-

EDTA-treated Xanthomonas campestris cells are used as both enzyme preparation and lipid-P acceptor, and UDP-Glc, GDP-Man, and UDP-glucuronic acid are used as sugar donors. A linear pentasaccharide unit is assembled on a polyprenol-phsophate lipid carrier by the sequential addition of glucose-1-phosphate, glucose, mannose, glucuronic acid, and mannose

704249

-

-

?

GDP-mannose + D-Glc-beta-(1->4)-Glc-alpha-1-diphosphopolyprenol

GDP + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphopolyprenol

Xanthomonas campestris

-

-

704257

-

-

?

GDP-mannose + D-Glc-beta-(1->4)-Glc-alpha-1-diphosphopolyprenol

GDP + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphosphopolyprenol

Xanthomonas campestris

-

the enzyme is involved in biosynthesis of xanthan

704257

-

-

?

additional information

?

-

Komagataeibacter xylinus

-

AceA Lys211 and Glu295 are involved in nucleotide sugar donor binding. Glu287 of the EX7E is a potential catalytic residue

704396

-

-

?

additional information

additional information

-

Xanthomonas oryzae

Q5GXZ4

GumH is involved in biosynthesis of the pentasaccharide repeating unit of xanthan. It is suggested that the wild-type Xanthomonas oryzae-produced xanthan is assembled by the sequential addition of UDP-glucose, UDP-glucose, GDP-mannose, UDPglucuronic acid, and GDP-mannose onto a polyprenol phosphate carrier, by the glycosyltransferase homologues encoded by the gumD, gumM, gumH, gumK, and gumI genes, respectively

702828

-

-

?