2.4.1.252: GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase

This is an abbreviated version!
For detailed information about GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase, go to the full flat file.

Reaction

Synonyms

AceA, alpha-mannosyltransferase AceA, GDP-mannosyltransferase, gumH

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.252 GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase

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Results	in table
117	AA Sequence
2	Application
4	Cloned(Commentary)
8	General Information
1	Inhibitors
1	Localization
1	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
10	Organism
2	Pathway
5	Protein Variants
1	Purification (Commentary)
1	Reaction
10	Reference
13	Substrates and Products (Substrate)
1	Subunits
9	Synonyms
1	Systematic Name

General Information

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General Information on EC 2.4.1.252 - GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

2 entries

physiological function

5 entries

additional information

Xanthomonas oryzae

Q5GXZ4

the gum gene cluster constitutes an operon expressed from multiple promoters located upstream of gumB and gumG, respectively. The existence of two internal promoters is newly identified in the Xanthomonas oryzae gum gene cluster through the insertion mutations with the rrnB transcriptional terminator and RT-PCR analyses

702815

malfunction

Xanthomonas campestris

-

from the biochemical analysis of a defined set of Xanthomonas campestris gum mutants, experimental data are reported for assigning functions to the products of the gum genes. Inactivation of gumH completely abolishes in vitro polymer formation. Permeabilized cells are incubated with UDP-glucose, GDPmannose, and UDP-glucuronic acid, one of them labeled in the sugar moiety. Accumulating intermediates are analysed. Oligosaccharides obtained from gumH- strain XcH can be resolved into two components: a compound with the same mobility as the disaccharide cellobiose and glucose. XcH cells labeled with UDP-[14C]glucuronic acid or GDP-[14C]mannose do not incorporate radioactivity into the 1203 extract

704257

malfunction

Xanthomonas oryzae

Q5GXZ4

significantly attenuated production of xanthan in knock-out mutant strain

702828

physiological function

Xanthomonas oryzae

Q5GXZ4

GumH is involved in biosynthesis of the pentasaccharide repeating unit of xanthan

702828

physiological function

Komagataeibacter xylinus

Q44571

the enzyme is involved in acetan polysaccharide synthesis. AceA can complement a Xanthomonas campestris mutant that is deficient in the homologous gene gumH (involved in xanthan biosynthesis)

704253

physiological function

Xanthomonas campestris

-

the enzyme is involved in biosynthesis of xanthan

704257

physiological function

Komagataeibacter xylinus

-

the enzyme is involved in the biosynthesis of the exopolysaccharide acetan

705743

physiological function

Xylella fastidiosa

-

GumH enzyme is an alpha-1,3-mannosyltransferase responsible for the transfer of mannose from GDP-mannose to the cellobiose-diphosphate-polyprenol carrier lipid during the assembly of the tetrasaccharide repeat unit of the exopolysaccharide fastidian gum

711062