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2.3.2.5: glutaminyl-peptide cyclotransferase

This is an abbreviated version!
For detailed information about glutaminyl-peptide cyclotransferase, go to the full flat file.

Word Map on EC 2.3.2.5

Reaction

L-glutaminyl-peptide
=
5-Oxoprolyl-peptide
 +
NH3

Synonyms

AtQC, cyclotransferase, glutaminyl-transfer ribonucleate, DromeQC, gamma-glutamylamine cyclotransferase, GGACT, glutamine cyclotransferase, glutaminyl cyclase, glutaminyl-peptide cyclotransferase-like protein, glutaminyl-tRNA cyclotransferase, golgi resident enzyme, Golgi resident glutaminyl cyclase, Golgi-resident enzyme, Golgi-resident glutaminyl cyclase, gQC, h-isoQC, h-QC, hQC, isoDromeQC, isoGlutaminyl cyclase, isoQC, PgQC, QC, QCT, Qpct, Qpct1, QPCTL, secretory glutaminyl cyclase, sQC, StQC

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.5 glutaminyl-peptide cyclotransferase

KM Value

KM Value on EC 2.3.2.5 - glutaminyl-peptide cyclotransferase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.24
2-amino-5-(butan-2-ylamino)-5-oxopentanoic acid
-
pH and temperature not specified in the publication
0.32
2-amino-5-(cyclohexylamino)-5-oxopentanoic acid
-
pH and temperature not specified in the publication
0.22
2-amino-5-(cyclopropylamino)-5-oxopentanoic acid
-
pH and temperature not specified in the publication
0.69
2-amino-5-oxo-5-(propan-2-ylamino)pentanoic acid
-
pH and temperature not specified in the publication
0.44
2-amino-5-oxo-5-[(2-phenylethyl)amino]pentanoic acid
-
pH and temperature not specified in the publication
0.38
2-amino-5-[(2-methylbutyl)amino]-5-oxopentanoic acid
-
pH and temperature not specified in the publication
1.62
2-amino-5-[(2S)-butan-2-ylamino]-5-oxopentanoic acid
-
pH and temperature not specified in the publication
0.38
2-amino-5-[[(2S)-2-methylbutyl]amino]-5-oxopentanoic acid
-
pH and temperature not specified in the publication
6
EFRH-NH2
-
at pH 6.5, 10times higher compared to KM-value of Gln substrate
4.6
EFRHHDSGYE-NH2
-
-
16
Gln
-
-
0.042
Gln 7-amido-4-methylcoumarin
-
pH 8.0, 30°C
0.087 - 0.155
Gln(3)-amyloid-beta peptide 3-11 amide
-
0.162
Gln(3)-amyloid-beta peptide 3-21 amide
-
pH 6.0, 30°C, 1% DMSO
-
0.089
Gln(3)-amyloid-beta peptide 3-40 amide
-
pH 6.0, 30°C, 1% DMSO
-
0.058 - 1.1
Gln-2-naphthylamide
0.054
Gln-7-amido-4-methylcoumarin
-
pH 8.0, 30°C
0.143 - 1.3
Gln-Ala
0.065 - 0.197
Gln-Ala-Ala-Ala-Ala-NH2
0.087 - 0.164
Gln-Ala-Ala-NH2
0.079 - 0.216
Gln-Ala-Ala-Ser-Ala-Ala-NH2
0.065 - 0.143
Gln-Arg-Gly-Ile-NH2
0.055 - 0.124
Gln-Arg-Tyr-Phe-NH2
0.153 - 0.172
Gln-Asn-Gly-Ile-NH2
0.07
Gln-beta-naphthylamide
-
pH 8.0, 30°C
0.038
Gln-beta-naphthylamine
-
pH 8.0, 30°C
0.044 - 29.53
Gln-Gln
0.31 - 0.53
Gln-Gln-Gln
0.148
Gln-Gln-OH
-
30°C, recombinant enzyme, expressed in Pichia pastoris
0.041 - 0.045
Gln-Gln-Tyr-Phe-NH2
0.094 - 0.61
Gln-Glu
0.077 - 0.102
Gln-Glu-Ala-Ala-NH2
0.039 - 0.081
Gln-Glu-Ala-Phe-NH2
0.055 - 0.107
Gln-Glu-Asp-Leu-NH2
0.069 - 0.113
Gln-Glu-Tyr-Ala-NH2
0.079 - 0.103
Gln-Glu-Tyr-NH2
0.047 - 0.1
Gln-Glu-Tyr-Phe-NH2
0.16 - 1.88
Gln-Gly
0.102 - 0.333
Gln-Gly-Pro
0.09
Gln-His-Pro-NH2
-
30°C, recombinant enzyme, expressed in Pichia pastoris
0.068 - 0.092
Gln-His-Tyr-Phe-NH2
0.034 - 0.118
Gln-Lys-Arg-Leu-NH2
0.401 - 7.15
Gln-NH2
0.06 - 0.1
Gln-Phe-Ala
0.069 - 0.111
Gln-Phe-Ala-NH2
0.149 - 18.89
Gln-Pro-Tyr-Phe-NH2
0.055 - 0.135
Gln-Ser-Tyr-Phe-NH2
0.223 - 6.7
Gln-tert-butyl ester
0.05 - 0.078
Gln-Trp-Ala-NH2
0.211
Gln-Tyr
-
pH 8.0, 30°C
0.058 - 0.101
Gln-Tyr-Ala
0.101 - 0.153
Gln-Tyr-Ala-OH
0.12 - 0.196
Gln-Val
0.019
glucagon(3-29)
-
pH 6.0, 30°C, 1% DMSO
-
0.32
glutamine tert-butyl ester
-
-
0.063
gonadotropin releasing hormone
-
-
0.017 - 0.105
H-Gln-7-amido-4-methylcoumarin
0.294 - 5
H-Gln-Ala-OH
0.487 - 2.3
H-Gln-Asp-Glu-Leu-NH2
0.028 - 0.17
H-Gln-beta-naphthylamide
0.053 - 1.5
H-Gln-Gln-OH
0.08 - 0.742
H-Gln-Glu-Ala-Phe-NH2
0.265 - 29.5
H-Gln-Glu-OH
0.33
H-Gln-Glu-Tyr-Ala-NH2
pH 8.0, 30°C
0.065 - 0.41
H-Gln-Glu-Tyr-Phe-NH2
0.424 - 7.1
H-Gln-Gly-OH
0.214 - 4.1
H-Gln-Gly-Pro-OH
0.06 - 0.448
H-Gln-Lys-Arg-Leu-NH2
0.48 - 2.048
H-Gln-NH2
0.106 - 0.44
H-Gln-Phe-Ala-NH2
0.128 - 0.35
H-Gln-Phe-Ala-OH
0.247
H-Gln-Ser-Tyr-Phe-NH2
pH 8.0, 30°C
0.72
H-Gln-Tyr-Ala-OH
30°C, isoDromeQC
0.014 - 0.282
H-Gln-Val-Ala-OH
0.14
L-gamma-glutamyl-(+)-3-aminobutyric acid
-
pH and temperature not specified in the publication
0.33
L-gamma-glutamyl-(+)-3-aminoisobutyric acid
-
pH and temperature not specified in the publication
0.91
L-gamma-glutamyl-beta-alanine
-
pH and temperature not specified in the publication
0.36
L-gamma-glutamyl-ethylamine
-
pH and temperature not specified in the publication
0.25
L-gamma-glutamyl-n-butylamine
-
pH and temperature not specified in the publication
0.32
L-gamma-glutamyl-n-propylamine
-
pH and temperature not specified in the publication
0.1
L-gamma-glutamylaniline
-
pH and temperature not specified in the publication
0.56
L-gamma-glutamylbenzylamine
-
pH and temperature not specified in the publication
0.084
L-gamma-glutamylcyclopentylamine
-
pH and temperature not specified in the publication
1.9
L-gamma-glutamylglycine
-
pH and temperature not specified in the publication
0.12
L-gamma-glutamylneohexylamine
-
pH and temperature not specified in the publication
0.61
L-gamma-glutamylneopentylamine
-
pH and temperature not specified in the publication
0.028 - 0.5
L-Gln-2-naphthylamide
0.048 - 0.3
L-Gln-7-amido-4-methylcoumarin
2.7 - 2.9
L-Gln-amide
0.41 - 3.8
L-Gln-Gly
0.17 - 1.791
L-Gln-Gly-L-Pro
0.294 - 1.838
L-Gln-L-Ala
0.32
L-Gln-L-Arg-Gly-L-Ile-NH2
pH 8.0, 30°C
0.36
L-Gln-L-Asn-Gly-L-Ile-NH2
pH 8.0, 30°C
0.487 - 1.74
L-Gln-L-Asp-L-Glu-L-Leu-NH2
0.053 - 20.4
L-Gln-L-Gln
0.265 - 4.2
L-Gln-L-Glu
0.08 - 0.742
L-Gln-L-Glu-L-Ala-L-Phe-NH2
0.33
L-Gln-L-Glu-L-Tyr-L-Ala-NH2
pH 8.0, 30°C
0.086 - 0.41
L-Gln-L-Glu-L-Tyr-L-Phe-NH2
0.06 - 0.448
L-Gln-L-Lys-L-Arg-L-Leu-NH2
0.106 - 0.44
L-Gln-L-Phe-L-Ala-NH2
0.247
L-Gln-L-Ser-L-Tyr-L-Phe-NH2
pH 8.0, 30°C
0.16
L-Gln-L-Thr-Gly-L-Ile-NH2
pH 8.0, 30°C
0.132
L-Gln-L-Thr-L-Ala
-
-
-
0.072
L-Gln-L-Trp-L-Ala-NH2
pH 8.0, 30°C
0.014 - 0.272
L-Gln-L-Val-L-Ala-NH2
0.48 - 2.048
L-Gln-NH2
0.151 - 8.2
L-Gln-tert-butyl ester
0.379 - 1.3
L-glutamine tert-butyl ester
0.0218
L-glutaminyl 2-naphthylamide
at pH 8.0 and 25°C
0.06
L-glutaminyl-2-naphthylamide
-
30°C, recombinant enzyme, expressed in Pichia pastoris
0.051
L-glutaminyl-4-methylcoumarinylamide
-
30°C, recombinant enzyme, expressed in Pichia pastoris
0.03 - 0.31
L-glutaminyl-7-amido-4-methylcoumarin
0.032 - 0.035
L-glutaminyl-beta-naphthylamide
0.032 - 0.063
N1-naphthalen-2-yl-L-glutamamide
0.27
Nepsilon-(L-gamma-glutamyl)-D-lysine
-
pH and temperature not specified in the publication
0.26
Nepsilon-(L-gamma-glutamyl)-L-lysine
-
pH and temperature not specified in the publication
20
O-(n-butylcarbamyl)-L-serine
-
pH and temperature not specified in the publication
1.1 - 1.6
QAAE
0.1 - 0.8
QAAF
0.4
QAAR
in 0.1 M MES, pH 7.5, temperature not specified in the publication
0.2 - 0.7
QAEA
2.1 - 2.5
QAFA
0.1 - 24.4
QARA
1 - 1.1
QEAA
0.16
QEDL
0.029 - 0.04
QEYF
1.9 - 3.5
QFAA
0.1 - 5.6
QGGG
0.9 - 2.9
QRAA
0.19
S-(cyclohexylamine)-L-cysteine
-
pH and temperature not specified in the publication
0.091
S-(n-butylcarbamyl)-L-cysteine
-
pH and temperature not specified in the publication
0.093
S-(n-propylcarbamyl)-L-cysteine
-
pH and temperature not specified in the publication
0.088
[Gln1,Gly4]-thyrotropin releasing hormone
-
-
-
0.087 - 0.151
[Gln1]-fertilization promoting peptide
-
0.031 - 0.033
[Gln1]-gastrin
-
0.053 - 0.054
[Gln1]-gonadotropin releasing-hormone
-
0.023 - 0.037
[Gln1]-neurotensin
0.09
[Gln1]-thyrotropin releasing-hormone
-
pH 8.0, 30°C
-
additional information
additional information
-